Abstract: The present invention relates to a combination of a curcuminoid and a taxane for use in the treatment of a hormone-refractory prostate cancer (HRPC) in a patient in need thereof.

Abstract: The present invention relates to a curcuminoid for enhancing the clinical efficacy of Docetaxel for the treatment of cancers and metastases.

Abstract: A postage meter has an improved means of monitoring the position of the cover providing access to the print rotor. A mechanical latch and associated mechanism is provided responsive to a cam on the print rotor and responsive to the movement of the cover, and the mechanism has an electrical sensor output to the processor of the postage meter. In the event that the cover is opened at a time when the rotor is away from its home position, for example at a time when the power to the meter has failed, the latch enters a latched state. Upon the restoration of power the meter determines if the rotor is away from its home position, and if it is, the meter inspects the sensor output to determine if the latch has been caused to enter its latched state. This condition is annunciated, for example by rendering the meter incapable of printing postage.

Abstract: A postage meter has the print rotor and platen within a single secure housing, with a letter detection lever along the paper path downstream from the rotor. The letter detection lever is in a spring-loaded coupling relationship with the trigger that triggers franking. If a letter remains in the meter due to a paper jam, the detection lever continues to be actuated and the spring-loaded coupling keeps the trigger in the triggered position. The meter further comprises a platen carrier moving the platen toward and away from the rotor; when the rotor is in its home position a radial cam on the rotor and cam follower keep the carrier away from the rotor. When franking of a letter begins and the rotor begins to rotate, the rotor cam releases the cam follower, permitting the carrier to move up in spring-loaded relation toward the rotor. A letter stopper is in the paper path downstream from the rotor and helps to align the letter so that the postage imprint is optimally oriented on the letter.

Abstract: A self-contained postage meter does not have a base separable from a main body. The single secure housing contains everything that would be in the main body of a prior art postage meter and everything that would be in a prior art meter base. Despite containing all these things, the single secure housing is small enough and light enough in weight to permit the entire meter to be readily transported to the post office for inspection or resetting. Within the single secure housing are the print rotor with value wheels, all the mechanisms for setting the print wheels, the descending and/or ascending register and associated microprocessor, and all the mechanisms for transport of the mail piece through the meter. Only a handful of controlled elements are required, chiefly a single inexpensive DC motor for franking and value wheel setting and a few electromagnets.