Abstract: The present invention relates to compounds useful in the prophylaxis and/or treatment of one or more fibrotic diseases. In particular, the compounds of the invention antagonize GPR84, a G-protein-coupled receptor. The present invention also provides pharmaceutical compositions comprising the compounds for use and methods for the prophylaxis and/or treatment of one or more fibrotic diseases by administering said compound.

Abstract: An actuator includes a motor, a drive member coupled to the motor and structured to transfer movement from the motor to an external mechanism, and a control chip configured to host a web server, connect with a wireless communication network and provide access to the web server via the wireless communication network, and control the motor using reprogrammable control logic. The reprogrammable control logic is adjustable by a user via the web server and the wireless communication network.

Abstract: A tool-holder column for a unit for converting a flat substrate that has two upper bearings (14, 16) each for supporting one end of an upper rotary tool (10), and two lower bearings (15, 17) each for supporting one end of a lower rotary tool (11), the flat substrate being movable longitudinally between the upper rotary tool (10) and the lower rotary tool (11), the bearings (14, 15, 16, 17) being vertically movable in opposite directions on either side of the longitudinal direction (L) of movement of the flat substrate, and a common drive for the bearings (14, 15, 16, 17) allowing the bearings (14, 15, 16, 17) to be moved simultaneously by one and the same distance in opposite directions, and including a screw device (25), the bearings (14, 15, 16, 17) being mounted one above another on the screw device (25) such that the rotation of the screw device (25) causes the linear movement of the bearings (14, 15, 16, 17) in opposite directions.

Abstract: A rotary-tool sleeve extractor for a unit for converting a flat substrate that includes a base (23) intended to be fixed to the conversion unit (7) and an extraction head (24) that: a) is movable with respect to the base (23) between a withdrawn position and a deployed position and, b) has a gripper (25) that can engage with a sleeve (13) of a rotary tool (10, 11).

Abstract: A bearing for holding a rotary conversion tool (10, 11) that includes two end rolling bearing devices (26, 28), at least one intermediate rolling bearing device (27) interposed between the end rolling bearing devices (26, 28), the end and intermediate rolling bearing devices (26, 27, 28) being intended to engage with an end (10a, 10b, 11a, 11b) of the rotary tool (10, 11), and at least one mechanical actuator (32, 33) configured to exert a radial preload force (Fo, Fo?) at the intermediate rolling bearing device (27).

Abstract: The present invention relates to compounds useful in the prophylaxis and/or treatment of one or more fibrotic diseases. In particular, the compounds of the invention antagonize GPR84, a G-protein-coupled receptor. The present invention also provides pharmaceutical compositions comprising the compounds for use and methods for the prophylaxis and/or treatment of one or more fibrotic diseases by administering said compound.

Abstract: A method for protecting a unit for converting a web substrate to limit a jam of the substrate inside the unit, the unit converting the substrate when the unit is stopped, in a packaging production machine: the steps of: detecting at the outlet of the unit that the converted web does not come out; stopping a motor of an infeed arrangement to prevent the substrate from entering the unit; stopping a motor of a feathering drive; and simultaneously stopping the machine, and guiding the substrate to an accumulation storage.

Abstract: A method for converting a flat substrate (W) in a station (3) for converting a flat substrate (W) that includes a rotary cutting unit (9) and at least one rotary deformation unit (7, 8) positioned upstream of the rotary cutting unit (9) in the direction of movement (L) of the flat substrate (W), the method including: determining the conversion parameters of the flat substrate (W), such as the deformation layout and cutting layout; choosing a sleeve (13) carrying a form for carrying out the deformation depending on the deformation layout; mounting the sleeve (13) on a mandrel (12) in the rotary deformation unit (7, 8); choosing the cutting tools (91, 92) depending on the cutting layout; mounting the cutting tools (91, 92) in the rotary cutting unit (9); and starting the conversion of the flat substrate (W).

Abstract: A rotary-tool mandrel for a unit for converting a flat substrate, on which a sleeve (13) is intended to be fitted, the mandrel includes a cylindrical core (14), a peripheral wall (17) that is able to take up a rest position and a locking position by exerting a radial pressure on the sleeve (13) in order to lock it in position on the mandrel (12), a pressure fluid circuit (21) provided between the peripheral wall (17) and the cylindrical core (14) for exerting the radial pressure on the sleeve (13), and a cooling fluid circuit (24) for allowing a fluid to flow in the region of the cylindrical core (14) and for cooling the mandrel (12).

Abstract: Cooling spray jet comprising a supply inlet, a discharge outlet, a reaming connecting the inlet and the outlet, the outlet having a given cross-sectional area, a valve comprising a plug free to slide in the reaming and bearing in contact with a valve seat in a closed state. The valve has two open states after a first phase in which the plug separates from the valve seat, with different ranges of fluid pressures, the cross-sectional area between the plug and the reaming of each opening state being different from the cross-sectional area of the other state, one of these opening states having a cross-sectional area that regulates the fluid flow at the discharge outlet and the other opening state having a cross-sectional area such that the flow is regulated by the cross-sectional area of the outlet.

Abstract: A rotary-tool sleeve extractor for a unit for converting a flat substrate that includes a base (23) intended to be fixed to the conversion unit (7) and an extraction head (24) that: a) is movable with respect to the base (23) between a withdrawn position and a deployed position and, b) has a gripper (25) that can engage with a sleeve (13) of a rotary tool (10, 11).

Abstract: A rotary-tool mandrel for a unit for converting a flat substrate, on which a sleeve (13) is intended to be fitted, the mandrel includes a cylindrical core (14), a peripheral wall (17) that is able to take up a rest position and a locking position by exerting a radial pressure on the sleeve (13) in order to lock it in position on the mandrel (12), a pressure fluid circuit (21) provided between the peripheral wall (17) and the cylindrical core (14) for exerting the radial pressure on the sleeve (13), and a cooling fluid circuit (24) for allowing a fluid to flow in the region of the cylindrical core (14) and for cooling the mandrel (12).

Abstract: A bearing for holding a rotary conversion tool (10, 11) that includes two end rolling bearing devices (26, 28), at least one intermediate rolling bearing device (27) interposed between the end rolling bearing devices (26, 28), the end and intermediate rolling bearing devices (26, 27, 28) being intended to engage with an end (10a, 10b, 11a, 11b) of the rotary tool (10, 11), and at least one mechanical actuator (32, 33) configured to exert a radial preload force (Fo, Fo?) at the intermediate rolling bearing device (27).

Abstract: A method for converting a flat substrate (W) in a station (3) for converting a flat substrate (W) that includes a rotary cutting unit (9) and at least one rotary deformation unit (7, 8) positioned upstream of the rotary cutting unit (9) in the direction of movement (L) of the flat substrate (W), the method including: determining the conversion parameters of the flat substrate (W), such as the deformation layout and cutting layout; choosing a sleeve (13) carrying a form for carrying out the deformation depending on the deformation layout; mounting the sleeve (13) on a mandrel (12) in the rotary deformation unit (7, 8); choosing the cutting tools (91, 92) depending on the cutting layout; mounting the cutting tools (91, 92) in the rotary cutting unit (9); and starting the conversion of the flat substrate (W).

Abstract: A tool-holder column for a unit for converting a flat substrate that has two upper bearings (14, 16) each for supporting one end of an upper rotary tool (10), and two lower bearings (15, 17) each for supporting one end of a lower rotary tool (11), the flat substrate being movable longitudinally between the upper rotary tool (10) and the lower rotary tool (11), the bearings (14, 15, 16, 17) being vertically movable in opposite directions on either side of the longitudinal direction (L) of movement of the flat substrate, and a common drive for the bearings (14, 15, 16, 17) allowing the bearings (14, 15, 16, 17) to be moved simultaneously by one and the same distance in opposite directions, and including a screw device (25), the bearings (14, 15, 16, 17) being mounted one above another on the screw device (25) such that the rotation of the screw device (25) causes the linear movement of the bearings (14, 15, 16, 17) in opposite directions.

Abstract: A method for protecting a unit for converting a web substrate to limit a jam of the substrate inside the unit, the unit converting the substrate when the unit is stopped, in a packaging production machine: the steps of: detecting at the outlet of the unit that the converted web does not come out; stopping a motor of an infeed arrangement to prevent the substrate from entering the unit; stopping a motor of a feathering drive; and simultaneously stopping the machine, and guiding the substrate to an accumulation storage.

Abstract: An arrangement (11) for driving a flat substrate along a longitudinal direction, the arrangement being mounted in a packaging production machine. The substrate has a surface that has sustained at least one modification. The arrangement includes a device (9) for driving the substrate along the longitudinal direction, and a device for bearing the substrate against the driving device (9), and having at least one bearing zone (23) facing toward the driving device (9). The substrate is engaged and driven between the driving device (9) and the bearing device. The bearing zone (23) has a transverse dimension (D) and position (Y), chosen as a function of a transverse dimension and a position of the modification on the substrate, so as to prevent damaging the modification between the driving device (9) and the bearing device.

Abstract: Cooling spray jet comprising a supply inlet, a discharge outlet, a reaming connecting the inlet and the outlet, the outlet having a given cross-sectional area, a valve comprising a plug free to slide in the reaming and bearing in contact with a valve seat in a closed state. The valve has two open states after a first phase in which the plug separates from the valve seat, with different ranges of fluid pressures, the cross-sectional area between the plug and the reaming of each opening state being different from the cross-sectional area of the other state, one of these opening states having a cross-sectional area that regulates the fluid flow at the discharge outlet and the other opening state having a cross-sectional area such that the flow is regulated by the cross-sectional area of the outlet.

Abstract: An arrangement (11) for driving a flat substrate along a longitudinal direction, the arrangement being mounted in a packaging production machine. The substrate has a surface that has sustained at least one modification. The arrangement includes a device (9) for driving the substrate along the longitudinal direction, and a device for bearing the substrate against the driving device (9), and having at least one bearing zone (23) facing toward the driving device (9). The substrate is engaged and driven between the driving device (9) and the bearing device. The bearing zone (23) has a transverse dimension (D) and position (Y), chosen as a function of a transverse dimension and a position of the modification on the substrate, so as to prevent damaging the modification between the driving device (9) and the bearing device.

Abstract: An arrangement (11) for driving a flat substrate along a longitudinal direction, the arrangement being mounted in a packaging production machine. The substrate has a surface that has sustained at least one modification. The arrangement includes a device (9) for driving the substrate along the longitudinal direction, and a device for bearing the substrate against the driving device (9), and having at least one bearing zone (23) facing toward the driving device (9). The substrate is engaged and driven between the driving device (9) and the bearing device. The bearing zone (23) has a transverse dimension (D) and position (Y), chosen as a function of a transverse dimension and a position of the modification on the substrate, so as to prevent damaging the modification between the driving device (9) and the bearing device.