Patents by Inventor Philippe Cleuziat
Philippe Cleuziat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7879581Abstract: Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.Type: GrantFiled: November 12, 2007Date of Patent: February 1, 2011Assignees: Gen-Probe Incorporated, BioMerieux S.A.Inventors: Steven T. Brentano, Markus T. Jucker, Francisco D. Delgado, Philippe Cleuziat, Marc Rodrigue
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Patent number: 7723095Abstract: A method for lysing prokaryotic or eukaryotic cells, or for simultaneous lysis of both, which includes at least three of the following: a mass of active, small-diameter beads corresponding to 50% or less than a mass of active, larger-diameter beads, and/or a total mass of lysing beads (consisting of a single type of bead or a mixture of smaller and larger beads) corresponding to between 50 and 100% of the total mass of the processed biological sample, and/or a lysis time of from 10 to 20 minutes, and/or seven or less non-lysing glass beads to drive the movement of the lysing beads, and/or from five to fifteen non-lysing iron beads to drive the movement of the lysing beads, depending on whether sonication, mechanical vortex centrifugation or magnetic vortex centrifugation is used.Type: GrantFiled: July 26, 2001Date of Patent: May 25, 2010Assignee: Biomerieux S.A.Inventors: Philippe Cleuziat, Sandra Incardona, Corinne Jay
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Publication number: 20090029360Abstract: Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.Type: ApplicationFiled: November 12, 2007Publication date: January 29, 2009Applicants: GEN-PROBE INCORPORATED, BIOMERIEUX S.A.Inventors: Steven T. Brentano, Markus T. Jucker, Francisco D. Delgado, Philippe Cleuziat, Marc Rodrigue
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Patent number: 7326533Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by their specific hybridization to portions of the amplified nucleic acid is disclosed. Compositions for amplifying and detecting in vitro the rpoB sequences of M. tuberculosis in a sample are disclosed.Type: GrantFiled: July 27, 2006Date of Patent: February 5, 2008Assignees: Gen-Probe Incorporated, BloMorloux S.A.Inventors: Markus T. Jucker, Steven T. Brentano, Francisco D. Delgado, Philippe Cleuziat
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Patent number: 7326532Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. Tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by their specific hybridization to portions of the amplified nucleic acid is disclosed. Compositions for amplifying and detecting in vitro the rpoB sequences of M. Tuberculosis in a sample are disclosed.Type: GrantFiled: July 28, 2006Date of Patent: February 5, 2008Assignees: Gen-Probe Incorporated, BioMerieux S.A.Inventors: Markus T. Jucker, Steven T. Brentano, Francisco D. Delgado, Philippe Cleuziat
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Patent number: 7294489Abstract: Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.Type: GrantFiled: September 18, 2003Date of Patent: November 13, 2007Assignees: Gen-Probe Incorporated, BioMerieux S.A.Inventors: Steven T. Brentano, Markus T. Jucker, Francisco D. Delgado, Philippe Cleuziat, Marc Rodrigue
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Publication number: 20060263823Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by their specific hybridization to portions of the amplified nucleic acid is disclosed. Compositions for amplifying and detecting in vitro the rpoB sequences of M. tuberculosis in a sample are disclosed.Type: ApplicationFiled: July 27, 2006Publication date: November 23, 2006Applicants: GEN-PROBE INCORPORATED, BIOMERIEUX S.A.Inventors: Markus Jucker, Steven Brentano, Francisco Delgado, Philippe Cleuziat
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Publication number: 20060263822Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences by using probes that provide information by their specific hybridization to portions of the amplified nucleic acid is disclosed. Compositions for amplifying and detecting in vitro the rpoB sequences of M. tuberculosis in a sample are disclosed.Type: ApplicationFiled: July 28, 2006Publication date: November 23, 2006Applicants: GEN-PROBE INCORPORATED, BIOMERIEUX S.A.Inventors: Markus Jucker, Steven Brentano, Francisco Delgado, Philippe Cleuziat
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Patent number: 7094542Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences using multiple probes that provide sequence information by their specific hybridization to portions of the amplified nucleic acid. Compositions for amplifying and detecting in vitro the rpoB sequences of M. tuberculosis in a sample are disclosed.Type: GrantFiled: September 18, 2002Date of Patent: August 22, 2006Assignee: Gen-Probe IncorporatedInventors: Markus T. Jucker, Steven T. Brentano, Francisco D. Delgado, Philippe Cleuziat
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Publication number: 20060049046Abstract: The invention concerns a sensor (1), in particular a biosensor, comprising an electrically or electronically insulating support (2), including at least one active surface (20), a plurality of electrically or electronically conductive electrodes (31,32), arranged on the active surface (2a) of the support in a predetermined operative arrangement, exposed, that is said electrodes can be jointly placed in contact with a common external medium, for example a liquid medium; a plurality of electric terminals (4) respectively corresponding to said electrodes (4), arranged on the active surface (2a, 2b) of the support, exposed, that is said terminals can be electrically or electronically connected outside, independently of one another; a plurality of electrically or electronically conductive strips (5), extending along one (2a) and/or the other (2d) of the support surfaces, connecting the plurality of electrodes (31,32) respectively to the plurality of terminals (4); an electrically or electronically insulating materiType: ApplicationFiled: July 18, 2003Publication date: March 9, 2006Applicant: APIBIOInventors: Marc Cuzin, Michel Guy, Philippe Cleuziat
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Publication number: 20050100915Abstract: Oligonucleotides used to prime in vitro nucleic acid amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species within the genus Mycobacterium are disclosed. Kits including such oligonucleotides are disclosed. Methods of detecting Mycobacterium species using the oligonucleotides in in vitro nucleic acid amplification are disclosed.Type: ApplicationFiled: September 18, 2003Publication date: May 12, 2005Inventors: Steven Brentano, Markus Jucker, Francisco Delgado, Philippe Cleuziat, Marc Rodrigue
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Patent number: 6686195Abstract: An apparatus including at least one sonotrode (2) designed to generate ultrasound of variable power in at least one biological sample (5) containing cells to be lysed, the sample (5) being contained in at least one receptacle (4 or 10) such that the sonotrode (2) is in direct contact with the receptacle(s) (4). Also disclosed is a method for using ultrasound to lyse a biological sample (5) contained in a receptacle (4), which includes placing the receptacle (4) in direct contact with the sonotrode (2), and activating the sonotrode (2) for long enough to lyse the cells in the sample (5) but preserve the DNA and/or RNA molecules released for subsequent operations, e.g. amplification. The invention is particularly applicable in the discipline of molecular biology.Type: GrantFiled: December 13, 2001Date of Patent: February 3, 2004Assignee: Biomerieux S.A.Inventors: Bruno Colin, Philippe Cleuziat, Patrick Broyer, Claude Mabilat, Sandra Incardona
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Patent number: 6664081Abstract: Methods of detecting Mycobacterium species using oligonucleotides to amplify in vitro 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species in the genus Mycobacterium are disclosed. Amplification oligonucleotides for in vitro amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences from many Mycobacterium species are disclosed. Kits containing oligonucleotides useful for in vitro amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences from many Mycobacterium species are disclosed.Type: GrantFiled: December 15, 2000Date of Patent: December 16, 2003Assignees: Gen-Probe Incorporated, Bio Merieux S.A.Inventors: Steven T. Brentano, Markus T. Jucker, Francisco D. Delgado, Philippe Cleuziat, Marc Rodrigue
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Patent number: 6632662Abstract: The invention concerns a device for lysis (1) of micro-organism to release at least one intracellular biological constituent, comprising a container (2) wherein are present a biological sample, in liquid medium, containing the micro-organism to be lyzed, and a material in the form of particles, relatively hard and inert with respect to the sample. The invention also concerns a grinding method. The material in the form of particles comprises at least two types of grinding means into different dimensions: at least large dimension magnetic means (3) automatically controlled by a magnetic field; and at least small dimension means (4) actuated by the large dimension grinding means (3). The invention is useful for separating biological constituents.Type: GrantFiled: March 2, 2001Date of Patent: October 14, 2003Assignee: Bio MerieuxInventors: Patrick Broyer, Philippe Cleuziat, Bruno Colin, Cécile Paris, Lyse Santoro
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Publication number: 20030180938Abstract: This invention concerns a method for the lysis of prokaryotic or eukaryotic cells, or for simultaneous lysis of both prokaryotic and eukaryotic cellsType: ApplicationFiled: April 18, 2003Publication date: September 25, 2003Inventors: Philippe Cleuziat, Sandra Incardona, Corinne Jay
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Publication number: 20030165824Abstract: Methods of detecting Mycobacterium species using oligonucleotides to amplify in vitro 16S rRNA sequences or DNA encoding 16S rRNA sequences for many species in the genus Mycobacterium are disclosed. Amplification oligonucleotides for in vitro amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences from many Mycobacterium species are disclosed. Kits containing oligonucleotides useful for in vitro amplification of 16S rRNA sequences or DNA encoding 16S rRNA sequences from many Mycobacterium species are disclosed.Type: ApplicationFiled: December 15, 2000Publication date: September 4, 2003Inventors: Steven T. Brentano, Markus T. Jucker, Francisco D. Delgado, Philippe Cleuziat, Marc Rodrigue
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Publication number: 20030108921Abstract: A method of detecting rpoB sequences of Mycobacterium tuberculosis present in a biological sample that includes steps of amplifying the M. tuberculosis rpoB sequence in vitro in a nucleic acid amplification mixture that includes specific disclosed primer sequences, and detecting the amplified sequences using multiple probes that provide sequence information by their specific hybridization to portions of the amplified nucleic acid. Compositions for amplifying and detecting in vitro the rpoB sequences of M. tuberculosis in a sample are disclosed.Type: ApplicationFiled: September 18, 2002Publication date: June 12, 2003Inventors: Markus T. Jucker, Steven T. Brentano, Francisco D. Delgado, Philippe Cleuziat
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Patent number: 6218151Abstract: The extension of primers capable of hybridizing to the nucleic acid of interest results in a process for generating single-stranded polynucleotides. The process includes contacting the nucleic acid of interest under conditions allowing extension of the primers with a first primer and a second primer capable of hybridizing to a first region and a second region, respectively, of the nucleic acid, wherein the second region overlaps with the first region.Type: GrantFiled: April 8, 1998Date of Patent: April 17, 2001Assignee: Bio MerieuxInventors: Philippe Cleuziat, Francoise Guillou-Bonnici, Francois Mallet, Pierre Levasseur
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Patent number: 6015531Abstract: The invention features an analysing device (1) comprising a body (2) in which are arranged or provided: an intake aperture (3) for a starting liquid sample, a liquid flow circuit (5) comprising at least one operating cell (6) for a processed liquid sample, obtained from all or part of the original sample, communicating with the said intake aperture (3), the said flow circuit defining, in at least two dimensions of the card, one determined geometric line, such that any alteration in the card orientation in a three-dimensional reference frame, causes the liquid to flow under gravity only, from one part of the said circuit to another,for instance from one side or another of the operating cell, (6) characterised in that, the flow circuit (5) is continuous, and looped on itself between the said aperture (3) and the said operating cell (6).Type: GrantFiled: March 5, 1998Date of Patent: January 18, 2000Assignee: Bio MerieuxInventors: Bruno Colin, Cecile Jaravel, Philippe Cleuziat
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Patent number: 5891681Abstract: An oligonucleotide is intended to be used as a promoter non-template strand in the transcription of a sequence of a nucleotide target in the presence of a phage RNA polymerase. The phage RNA polymerase has specific natural promoters containing a consensus sequence from at least position -17 to position -1. The oligonucleotide contains a core sequence flanked at at least one of its ends by a nucleotide sequence capable of hybridization with a sequence of the target. The core sequence contains a sequence of 6 to 9 consecutive nucleotides from the region -12 to -4 of the non-template strand of the specific promoter, or a sufficiently homologous sequence to enable the functionality of the RNA polymerase to be retained.Type: GrantFiled: December 20, 1994Date of Patent: April 6, 1999Assignee: Bio MerieuxInventors: Francois Mallet, Francoise Guillou-Bonnici, Philippe Cleuziat, Pierre Levasseur