Abstract: The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing ?133p53? isoform, ?133p53? isoform, or both ?133p53? and ?133p53? isoforms expression; and also to screening methods for anti-cancer stem cells agents.

Abstract: The present invention is in the field of oncology, and more particularly of cancer stem cells. It relates to a method for producing cancer stem cells based on overexpression of ?133?536 isoform, ?133?53? isoform, or both ?133?536 and ?133?53? isoforms; a method for predicting the risk that treatment with a chemotherapeutic anti-cancer agent induces cancer stem cells in a subject suffering from cancer from a cancer sample of said subject, based on detection of an increase in ?133?536 isoform, ?133?53? isoform, or both ?133?536 and ?133?53? isoforms following chemotherapeutic anti-cancer treatment; to therapeutic uses of a combination of chemotherapeutic anti-cancer agent and an agent reducing ?133p536 isoform, ?133?53? isoform, or both ?133?536 and ?133?53? isoforms expression; and also to screening methods for anti-cancer stem cells agents.

Abstract: The invention relates to the use of compounds derived from pyrimidinetrione of general formula (I) as acetyl cholinesterase (AChE) inhibitors. The invention also relates to the use of said compounds as insecticides, and to compositions containing the same.

Abstract: The invention relates to a novel acetylcholinesterase gene (ace-1) responsible for resistance to organophosphorus and/or carbamates in mosquitoes, which is non-homologous to the D. melanogaster acetylcholinesterase gene (ace-2), products of the ace-1 gene (cDNA, protein AchE1) and the applications thereof, particularly for the screening of novel insecticides and the genetic detection of resistance to organophosphorus and/or carbamates in mosquito populations.

Abstract: The invention relates to the use of compounds derived from pyrimidinetrione of general formula (I) as acetyl cholinesterase (AChE) inhibitors. The invention also relates to the use of said compounds as insecticides, and to compositions containing the same.

Abstract: The invention relates to a novel acetylcholinesterase gene (ace-1) responsible for resistance to organophosphorus and/or carbamates in mosquitoes, which is non-homologous to the D. melanogaster acetylcholinesterase gene (ace-2), products of the ace-1 gene (cDNA, protein AchE1) and the applications thereof, particularly for the screening of novel insecticides and the genetic detection of resistance to organophosphorus and/or carbamates in mosquito populations.

Abstract: A rotary motor driven tool comprising a motor, and a driven part, the motor being adapted to rotate the driven part, and a torque limiting device adapted to limit torque output of the driven part to a maximum output torque magnitude, wherein the tool further includes a switching apparatus which operates automatically to initiate switching of the maximum output torque set by the torque limiting device from a first lower magnitude to a second higher magnitude when a predetermined threshold is reached.

Abstract: A computer bus system is provided with at least two parallel bus lines and at least a first and a second connector, each connector including at least two bus terminals. Each is connected to a respective bus line, and at least one non-bus terminal is not connected to a bus line. The first connector is an image of the second connector, rotated through 180 degrees. This image rotation maps each bus terminal of the second connector to a respective bus terminal of the first connector, and maps a predetermined non-bus terminal of the second connector to a predetermined non-bus terminal of the first connector. The predetermined non-bus terminals of the two connectors are electrically connected. Also provided are circuit cards adapted to be used with such a bus, each card include switches that map the received signals according to the direction of the connectors. The overall arrangement allows staggered mounting of cards on the bus, shorter parallel bus lines, and more efficient cooling.