Abstract: A method for reducing or stopping flow through a tubular structure of a patient can include positioning an elongate member within a lumen of the tubular structure. The elongate member can be arranged to form a frame having a distal opening and a proximal opening. The elongate member can substantially reduce or totally obstruct, with a flow reducing member coupled to the frame, flow of at least one of emboli and fluid flowing through the lumen. The flow reducing member can comprise a one-way valve that moves in response to fluid flow to substantially prevent distal flow through the distal opening and to allow proximal flow through the distal opening.

Abstract: The invention features alginate and alginate lyase compositions and methods that are useful for the treatment of various conditions and diseases. The invention also provides kits and instructions for use.

Abstract: An expandable device can be delivered to a luminal structure in a patient using a delivery system. The delivery system can include an elongate carrier member and an engagement component that can releasably engage the expandable device. The elongate carrier member can have a distal portion, a central axis, and a first notch in the distal portion. The engagement component can be positioned within the first notch. Further, the expandable frame can be coupled to the distal portion of the carrier member and have a first terminal end section. When coupled to the carrier member, the first terminal and section can (i) pass from a first end of the first notch through a space between the central axis and the engagement component and (ii) terminate outside of the first notch, beyond a second end of the first notch.

Abstract: The invention features alginate and alginate lyase compositions and methods that are useful for the treatment of various conditions and diseases. The invention also provides kits and instructions for use.

Abstract: A device for delivering an expandable member to a luminal structure in a patient is described. In some embodiments, the device has a carrier member, with a carrier lumen extending at least partially therethrough. The device can have an elongate member that extends through the carrier lumen across a first notch in the carrier member. The device can have an expandable member that expands within and engages the luminal structure, can be carried by the carrier member, and has a first portion that fits within the first notch. When the elongate member extends through the carrier lumen and across the first notch, the elongate member secures the first portion to the carrier member. The elongate member is configured to move axially through the carrier lumen such that the elongate member permits release of the first portion from the carrier member and expansion of at least part of the expandable member.

Abstract: A method for reducing or stopping flow through a tubular structure of a patient can include positioning an elongate member within a lumen of the tubular structure. The elongate member can be arranged to form a frame having a distal opening and a proximal opening. The elongate member can substantially reduce or totally obstruct, with a flow reducing member coupled to the frame, flow of at least one of emboli and fluid flowing through the lumen. The flow reducing member can comprise a one-way valve that moves in response to fluid flow to substantially prevent distal flow through the distal opening and to allow proximal flow through the distal opening.

Abstract: An occluding device including expandable scaffold and a flow-limiting member is described. In some embodiments the scaffold is an expandable or self-expanding stent deliverable over a guide wire. The flow-limiting member can include a valve that can be closed following deployment. On deployment the stent and flow-limiting member can engage an inner surface of a body cavity lumen, blocking flow of material. In some embodiments the body cavity is a blood vessel, and the device can be used to block blood flow. In some embodiments the device includes bioactive agents.

Abstract: The invention features catheters, hydrogel compositions, and methods that useful for the treatment of various conditions and diseases. The invention also provides kits and instructions for use.

Abstract: An occluding device including expandable scaffold and a flow-limiting member is described. In some embodiments the scaffold is an expandable or self-expanding stent deliverable over a guide wire. The flow-limiting member can include a valve that can be closed following deployment. On deployment the stent and flow-limiting member can engage an inner surface of a body cavity lumen, blocking flow of material. In some embodiments the body cavity is a blood vessel, and the device can be used to block blood flow. In some embodiments the device includes bioactive agents.

Abstract: A device for delivering an expandable member to a luminal structure in a patient is described. In some embodiments, the device has a carrier member, with a carrier lumen extending at least partially therethrough. The device can have an elongate member that extends through the carrier lumen across a first notch in the carrier member. The device can have an expandable member that expands within and engages the luminal structure, can be carried by the carrier member, and has a first portion that fits within the first notch. When the elongate member extends through the carrier lumen and across the first notch, the elongate member secures the first portion to the carrier member. The elongate member is configured to move axially through the carrier lumen such that the elongate member permits release of the first portion from the carrier member and expansion of at least part of the expandable member.

Abstract: The invention features alginate and alginate lyase compositions and methods that are useful for the treatment of various conditions and diseases. The invention also provides kits and instructions for use.

Abstract: An occluding device including expandable scaffold and a flow-limiting member is described. In some embodiments the scaffold is an expandable or self-expanding stent deliverable over a guide wire. The flow-limiting member can include a valve that can be closed following deployment. On deployment the stent and flow-limiting member can engage an inner surface of a body cavity lumen, blocking flow of material. In some embodiments the body cavity is a blood vessel, and the device can be used to block blood flow. In some embodiments the device includes bioactive agents.