Patents by Inventor Philippe Gain
Philippe Gain has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12766225Abstract: The invention concerns a process for preparing an allograft or xenograft material from a lens capsule, wherein the process comprises the following steps: Decellularizing (200) a lens capsule to obtain a decellularized lens capsule, Depositing (300) the decellularized capsule on a microporous support membrane to obtain a stack composed of the decellularized lens capsule and the support membrane, Lyophilizing (400) the stack to obtain a lyophilized stack, Sterilizing (500) the lyophilized stack to obtain a sterilized stack, Packaging (600) the sterilized stack to obtain allograft or xenograft materials.Type: GrantFiled: July 22, 2020Date of Patent: October 20, 2026Assignees: UNIVERSITE JEAN MONNET SAINT ETIENNE, CENTRE HOSPITALIER UNIVERSITAIREInventors: Philippe Gain, Gilles Thuret, Zhiguo He
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Patent number: 12605243Abstract: The invention concerns a cutting process for producing a plurality of implants from a previously removed human or animal cornea, wherein the process comprises the following steps: depositing (200) the cornea in a holding device, cutting (300), using a laser source, the cornea contained in the holding device to obtain a cut cornea, detaching (400) each implant from the cut cornea, decellularizing (500) each detached implant to obtain decellularized implants, lyophilizing (600) each decellularized implant to obtain lyophilized implants, sterilizing (700) each lyophilized implant to obtain sterilized implants, packaging (800) each sterilized implant to obtain packaged implants.Type: GrantFiled: July 22, 2020Date of Patent: April 21, 2026Assignees: UNIVERSITE JEAN MONNET SAINT ETIENNE, MANUTECH-USD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER UNIVERSITAIREInventors: Philippe Gain, Gilles Thuret, Cyril Mauclair, Samy Albourgol, Gregory Egaud
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Publication number: 20250325181Abstract: The invention relates to a device for examining the anterior part of the eye by retro-illumination of said anterior part. This device has means for illuminating the eye, comprising a light source (1), and means for imaging the anterior part of the eye. The invention consists in the device further comprising means of modulating at least one region of the light beam emitted from the light source (1).Type: ApplicationFiled: June 1, 2023Publication date: October 23, 2025Inventors: Philippe GAIN, Anthony AIN, Gilles THURET, Thierry LEPINE
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Publication number: 20240216547Abstract: The invention relates to fluorescein derivative compounds and the use thereof as fluorescent markers. Said markers can be used in particular in biology and in medicine, particularly in the field of ophthalmology. The non-fluorescent fluorescein derivatives are activated in the cell, thereby allowing the detection of living cells as well as the quantification of cell viability by fluorescence, without being toxic to cells.Type: ApplicationFiled: April 28, 2022Publication date: July 4, 2024Inventors: Philippe GAIN, Gilles THURET, Emilie COURRIER, Zhiguo HE, Gilles ULRICH, Antoinette DE NICOLA, Corantin MAURIN, Corentin MARET
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Patent number: 11974569Abstract: The present invention relates to a device for holding human or animal corneal tissue previously removed for photon treatment thereof with electromagnetic radiation, notable in that the holding device comprises: a stack of elements along a longitudinal axis (A-A?) of the device, said stack comprising: a first plate (1) that is transparent to the electromagnetic radiation, a peripheral seal (4) positioned on the first plate (1), the peripheral seal (4) being intended to extend around the corneal tissue (6), a second plate (2) that is transparent to the electromagnetic radiation on the peripheral seal (4), an immobilizing system (51, 52) for immobilizing the stack of elements and able to press the first and second plates (1, 2) firmly against the corneal tissue in order to apply mechanical stress to the anterior and posterior faces of the corneal tissue.Type: GrantFiled: July 17, 2019Date of Patent: May 7, 2024Assignees: UNIVERSITE JEAN MONNET, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, CENTRE HOSPITALIER UNIVERSITAIRE, MANUTECH-USDInventors: Philippe Gain, Gilles Thuret, Cyril Mauclair, Clotilde Jumelle, Gregory Egaud
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Publication number: 20220257418Abstract: A device for cutting human or animal tissue including a femtosecond laser that can emit a L.A.S.E.R. beam in the form of impulses. The device directs and focuses the beam onto or into the tissue for the cutting thereof. The device further includes and element to shape the L.A.S.E.R. beam, positioned in the trajectory of the beam, and to modulate the energy distribution of the L.A.S.E.R. beam in the focal plane thereof, corresponding to the cutting plane.Type: ApplicationFiled: May 3, 2022Publication date: August 18, 2022Inventors: Aurelien BERNARD, Philippe GAIN, Cyril MAUCLAIR, Gilles THURET
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Publication number: 20220249222Abstract: The invention concerns a cutting process for producing a plurality of implants from a previously removed human or animal cornea, wherein the process comprises the following steps: depositing (200) the cornea in a holding device, cutting (300), using a laser source, the cornea contained in the holding device to obtain a cut cornea, detaching (400) each implant from the cut cornea, decellularizing (500) each detached implant to obtain decellularized implants, lyophilizing (600) each decellularized implant to obtain lyophilized implants, sterilizing (700) each lyophilized implant to obtain sterilized implants, packaging (800) each sterilized implant to obtain packaged implants.Type: ApplicationFiled: July 22, 2020Publication date: August 11, 2022Inventors: Philippe GAIN, Gilles THURET, Cyril MAUCLAIR, Samy ALBOURGOL, Gregory EGAUD
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Publication number: 20220241463Abstract: The invention concerns a process for preparing an allograft or xenograft material from a lens capsule, wherein the process comprises the following steps: Decellularizing (200) a lens capsule to obtain a decellularized lens capsule, Depositing (300) the decellularized capsule on a microporous support membrane to obtain a stack composed of the decellularized lens capsule and the support membrane, Lyophilizing (400) the stack to obtain a lyophilized stack, Sterilizing (500) the lyophilized stack to obtain a sterilized stack, Packaging (600) the sterilized stack to obtain allograft or xenograft materials.Type: ApplicationFiled: July 22, 2020Publication date: August 4, 2022Inventors: Philippe GAIN, Gilles THURET, Zhiguo HE
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Patent number: 11351062Abstract: A device for cutting human or animal tissue including a femtosecond laser that can emit a L.A.S.E.R. beam in the form of impulses. The device directs and focuses the beam onto or into the tissue for the cutting thereof. The device further includes and element to shape the L.A.S.E.R. beam, positioned in the trajectory of the beam, and to modulate the energy distribution of the L.A.S.E.R. beam in the focal plane thereof, corresponding to the cutting plane.Type: GrantFiled: October 7, 2015Date of Patent: June 7, 2022Assignees: UNIVERSITE JEAN MONNET SAINT ETIENNE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Aurelien Bernard, Philippe Gain, Cyril Mauclair, Gilles Thuret
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Patent number: 11229202Abstract: The invention relates to a medical device in the form of a cartridge (2) incorporating an assembly permitting the preservation of corneal tissue that has been obtained beforehand by sampling, the device comprising: a storage compartment (24) containing a preserving fluid, at least one input terminal (21) upstream from the storage compartment (24), for injecting a compressed pressurizing gas, at least one control terminal (22) upstream from the storage compartment (24), for injecting a compressed control gas, a pneumatically controlled switching system (26) downstream from the terminals (21, 22), said switching system (26) being controlled by the compressed control gas in order to permit or prohibit the circulation of the compressed pressurizing gas towards the storage compartment (24).Type: GrantFiled: December 14, 2018Date of Patent: January 25, 2022Assignees: UNIVERSITE JEAN MONNET, CENTRE HOSPITALIER UNIVERSITAIREInventors: Philippe Gain, Gilles Thuret, Pascal Herbepin
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Patent number: 11229201Abstract: The invention relates to a medical device for preservation of corneal tissue (3) that has been obtained beforehand by sampling, the device comprising a base (11), at least one side wall (12), and means for receiving and blocking the corneal tissue (3), characterized in that the device additionally comprises an applanation lid (13) for covering an opening of the device opposite the transparent base (11), the applanation lid (13) comprising: a transparent window (131), and a support (132) between the window (131) and the side wall (12), the support (132) comprising means for moving the window (131) in translation with respect to the side wall (12) of the device.Type: GrantFiled: December 14, 2018Date of Patent: January 25, 2022Assignees: UNIVERSITE JEAN MONNET, CENTRE HOSPITALIER UNIVERSITAIREInventors: Philippe Gain, Gilles Thuret, Pascal Herbepin
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Publication number: 20210321607Abstract: The present invention relates to a device for holding human or animal corneal tissue previously removed for photon treatment thereof with electromagnetic radiation, notable in that the holding device comprises: a stack of elements along a longitudinal axis (A-A?) of the device, said stack comprising: a first plate (1) that is transparent to the electromagnetic radiation, a peripheral seal (4) positioned on the first plate (1), the peripheral seal (4) being intended to extend around the corneal tissue (6), a second plate (2) that is transparent to the electromagnetic radiation on the peripheral seal (4), an immobilizing system (51, 52) for immobilizing the stack of elements and able to press the first and second plates (1, 2) firmly against the corneal tissue in order to apply mechanical stress to the anterior and posterior faces of the corneal tissue.Type: ApplicationFiled: July 17, 2019Publication date: October 21, 2021Inventors: Philippe GAIN, Gilles THURET, Cyril MAUCLAIR, Clotilde JUMELLE, Gregory EGAUD
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Publication number: 20210084892Abstract: The invention relates to a medical device for preservation of corneal tissue (3) that has been obtained beforehand by sampling, the device comprising a base (11), at least one side wall (12), and means for receiving and blocking the corneal tissue (3), characterized in that the device additionally comprises an applanation lid (13) for covering an opening of the device opposite the transparent base (11), the applanation lid (13) comprising: a transparent window (131), and a support (132) between the window (131) and the side wall (12), the support (132) comprising means for moving the window (131) in translation with respect to the side wall (12) of the device.Type: ApplicationFiled: December 14, 2018Publication date: March 25, 2021Inventors: Philippe GAIN, Gilles THURET, Pascal HERBEPIN
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Publication number: 20210076667Abstract: The invention relates to a medical device in the form of a cartridge (2) incorporating an assembly permitting the preservation of corneal tissue that has been obtained beforehand by sampling, the device comprising: a storage compartment (24) containing a preserving fluid, at least one input terminal (21) upstream from the storage compartment (24), for injecting a compressed pressurizing gas, at least one control terminal (22) upstream from the storage compartment (24), for injecting a compressed control gas, a pneumatically controlled switching system (26) downstream from the terminals (21, 22), said switching system (26) being controlled by the compressed control gas in order to permit or prohibit the circulation of the compressed pressurizing gas towards the storage compartment (24).Type: ApplicationFiled: December 14, 2018Publication date: March 18, 2021Inventors: Philippe GAIN, Gilles THURET, Pascal HERBEPIN
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Patent number: 10188097Abstract: A device for the storage of a corneal specimen has means for the reception and entrapment of a corneal specimen, connected to the means for the creation of a pressure gradient with overpressure on the endothelial side and to the preservation medium circulation means in the layouts that present the means for the reception and entrapment of the cornea specimen. The means for the reception and entrapment of the corneal specimen entrap the sclera ciliary zone surrounding the cornea in an airtight manner to delimit a separate endothelial chamber and epithelial chamber in which the preservation medium can circulate with an overpressure in the endothelial chamber; The intermediate component and the endothelial lid comprise inlet and outlet orifices for the preservation medium which are connected to the means for the circulation of the preservation medium and the creation of a pressure gradient between the endothelial chamber and the epithelial chamber with overpressure in the endothelial chamber.Type: GrantFiled: March 14, 2013Date of Patent: January 29, 2019Assignees: UNIVERSITE JEAN MONNET, ECOLE NATIONALE D'INGENIEURS DE SAINT-ETIENNE, ETABLISSEMENT FRANCAIS DU SANGInventors: Philippe Gain, Gilles Thuret, Sophie Laverne-Acquart, Sébastien Soubaigne
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Publication number: 20170304118Abstract: The invention relates to a device (1) for cutting human or animal tissue, such as a cornea (3), or a crystalline lens, said device comprising a femtosecond laser (2) that can emit a L.A.S.E.R. beam (4) in the form of impulses, and means for directing and focusing said beam onto or into the tissue for the cutting thereof as such. According to the invention, the device comprises means (9) for shaping the L.A.S.E.R. beam (4), which are positioned in the trajectory of said beam, and can modulate the energy distribution of the L.A.S.E.R. beam (4) in the focal plane thereof, corresponding to the cutting plane.Type: ApplicationFiled: October 7, 2015Publication date: October 26, 2017Inventors: Aurelien BERNARD, Philippe GAIN, Cyril MAUCLAIR, Gilles THURET
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Publication number: 20160029618Abstract: A device for the storage of a corneal specimen has means for the reception and entrapment of a corneal specimen, connected to the means for the creation of a pressure gradient with overpressure on the endothelial side and to the preservation medium circulation means in the layouts that present the means for the reception and entrapment of the cornea specimen. The means for the reception and entrapment of the corneal specimen entrap the sclera ciliary zone surrounding the cornea in an airtight manner to delimit a separate endothelial chamber and epithelial chamber in which the preservation medium can circulate with an overpressure in the endothelial chamber; The intermediate component and the endothelial lid comprise inlet and outlet orifices for the preservation medium which are connected to the means for the circulation of the preservation medium and the creation of a pressure gradient between the endothelial chamber and the epithelial chamber with overpressure in the endothelial chamber.Type: ApplicationFiled: March 14, 2013Publication date: February 4, 2016Inventors: Philippe Gain, Gilles Thuret, Sophie Laverne-Acquart, Sébastien Soubaigne