Abstract: A snowshoe (1) in the form of an elongated plate called a mesh, onto which a fastener (3) is mounted, intended to hold the shoe of the user in place, the mesh being formed by an elongated plate comprising a front portion (6) called a spatula (6) extended rearward (AR) by a rear part, formed by a central portion (5) extended by a rear portion (7), the front portion (6) being curved upward to form the spatula, characterized in that the rear part is flexible at least longitudinally and at least in the central portion (5), while the front portion (6) of the mesh is rigid so as to be less flexible than the rear part, i.e. the other portions, particularly the central portion and the rear portion.

Abstract: A mount for a snowshoe comprising front holding means and rear holding means, each holding means being constituted by a holding member for the boot, at least one of the holding members comprising at least one abutment element allowing the corresponding holding member to be in constrained abutment against the boot, and the holding member is movable between a boot release position and a boot holding position, the mount furthermore comprising means for causing displacement of the holding member from its release position toward its holding position, in which position it is in abutment against the boot, those means being constituted by a movable part arranged under the region occupied by the boot, connected at least kinematically to the corresponding holding member, actuation of the movable part by the boot during attachment causing displacement of the corresponding holding member toward its holding position, the abutment element being a flexible element.

Abstract: A snowshoe (1) in the form of an elongated plate called a mesh, onto which a fastener (3) is mounted, intended to hold the shoe of the user in place, the mesh being formed by an elongated plate comprising a front portion (6) called a spatula (6) extended rearward (AR) by a rear part, formed by a central portion (5) extended by a rear portion (7), the front portion (6) being curved upward to form the spatula, characterised in that the rear part is flexible at least longitudinally and at least in the central portion (5), while the front portion (6) of the mesh is rigid so as to be less flexible than the rear port, i.e. the other portions, particularly the central portion and the rear portion.

Abstract: In an embodiment of the present disclosure there is provided a method of inactivating enveloped DNA virus particles in a biological sample. In an embodiment, such a method comprises contacting the biological sample with an effective amount of an antiviral composition comprising PD 404,182 In some embodiments, the DNA virus is the Herpes Simplex virus-1 (HSV-1) or the Herpes Simplex Virus-2 (HSV-2). In another embodiment of the present disclosure, there is provided a method of treating, preventing, or reducing a viral infection caused by an enveloped DNA virus in a subject in need thereof. In yet another embodiment, there is provided a method of preventing transmission of a viral infection to a subject in need thereof.

Abstract: In some embodiments the present disclosure provides a method of inactivating a RNA virus of the family retroviridae in a biological sample. Such a method comprises contacting the biological sample with an effective amount of an antiviral composition comprising PD 404,182. In an embodiment of the present disclosure the RNA virus is selected from the group consisting of HIV pseudotyped lentiviruses, primary human immunodeficiency virus-1 isolates (HIV-1), human immunodeficiency virus-2 (HIV-2), and simian immunodeficiency virus (SIV). Further embodiments of the present disclosure pertain to a method of treating a subject infected by a RNA virus of the family retroviridae. Another embodiment of the present invention pertains to a method of preventing transmission of a RNA virus of the family retroviridae in a subject in need thereof.

Abstract: A snowshoe (1) whose webbing includes a flexible wall (4) maintained in tension inside a framework (2) by portions of the flexible mounting wall which define flexible mounting projections. Supplemental protection parts (8) are disposed surrounding the mounting projections to protect them from wear and impact.

Abstract: A snowshoe (1) made of a frame (2) holding a deck (3) meant to hold the user's boot, the aforementioned boot being held on the deck by a binding, characterized in that the snowshoe includes a transverse retaining element (4) extending transversely at the front of the user's foot, the aforesaid transverse element (4) being held by its lateral ends to the frame (2), while the aforementioned transverse element (4) is made of the combination of an upper transverse element (4a) and a lower transverse element (4b) so that the frame (2) is sandwiched between the ends of the respective transverse elements (4a, 4b).

Abstract: A device for laterally retaining a boot on a snowshoe (1), comprises a retaining plate (3) with a plane of general symmetry (P), on which are mounted front retaining means (4) made up of an assembly of retaining walls (4a, 4b) forming an enclosure in which the front and/or rear end of the boot is to be engaged. The device includes an adjustment structure for adjusting the distance between the two lateral retaining walls (4a, 4b), that is between a left wall (4a) and a right wall (4b).

Abstract: A snowshoe (1) whose binding (5) for retaining of the boot is mounted on a cross-piece (9) whose ends are mounted laterally to the snowshoe itself, characterized in that the aforementioned ends are mounted via two couplings (7a, 7b) of two rings, namely a left coupling (7a) and a right coupling (7b).

Abstract: A snowshoe (1) includes a binding (4) intended to retain the boot of the user and a plate pivoting around a transverse pivot axis (X, X?) including a retaining assembly for the boot. A longitudinal position of the rear retaining assembly is adjustable for in order to conform the longitudinal dimension of binding, with the size of the boot, by displacement toward the front or towards the rear and locking it in the chosen position. The front retaining stirrup is mounted to a front horizontally extending plate (7), which is pivotally retained on the webbing around the pivot axis (X, X?), while the rear retaining part is mounted on a lower support wall (9), extended toward the front by a sliding member (10) intended to cooperate, with a slide channel of corresponding form defined under the front plate (7) of the front retaining assembly (4a).

Abstract: A device for laterally retaining a boot on a snowshoe (1), comprises a retaining plate (3) with a plane of general symmetry (P), on which are mounted front retaining means (4) made up of an assembly of retaining walls (4a, 4b) forming an enclosure in which the front and/or rear end of the boot is to be engaged. The device includes an adjustment structure for adjusting the distance between the two lateral retaining walls (4a, 4b), that is between a left wall (4a) and a right wall (4b).

Abstract: A snowshoe (1) made of a frame (2) holding a deck (3) meant to hold the user's boot, the aforementioned boot being held on the deck by a binding, characterized in that the snowshoe includes a transverse retaining element (4) extending transversely at the front of the user's foot, the aforesaid transverse element (4) being held by its lateral ends to the frame (2), while the aforementioned transverse element (4) is made of the combination of an upper transverse element (4a) and a lower transverse element (4b) so that the frame (2) is sandwiched between the ends of the respective transverse elements (4a, 4b).

Abstract: A snowshoe (1) includes a binding (4) intended to retain the boot of the user and a plate pivoting around a transverse pivot axis (X, X?) including a retaining assembly for the boot. A longitudinal position of the rear retaining assembly is adjustable for in order to conform the longitudinal dimension of binding, with the size of the boot, by displacement toward the front or towards the rear and locking it in the chosen position. The front retaining stirrup is mounted to a front horizontally extending plate (7), which is pivotally retained on the webbing around the pivot axis (X, X?), while the rear retaining part is mounted on a lower support wall (9), extended toward the front by a sliding member (10) intended to cooperate, with a slide channel of corresponding form defined under the front plate (7) of the front retaining assembly (4a).

Abstract: A snowshoe (1) whose webbing includes a flexible wall (4) maintained in tension inside a framework (2) by portions of the flexible mounting wall which define flexible mounting projections. Supplemental protection parts (8) are disposed surrounding the mounting projections to protect them from wear and impact.

Abstract: A device (1) for retaining the front of a boot on a snowshoe, said device including an assembly of retention walls (2, 3a, 3b) forming an enclosure opening towards the rear (AR) and in which the front end of the boot is intended to be received, characterized in that the enclosure is made of two side retention walls (3a, 3b), namely a left wall (3a) and a right wall (3b), and a front retention wall (2) made of a deformable plastic material making a body with a front support plate (5) on which the front of the sole of the boot is supported, wherein the retention walls (2, 3a, 3b) are intended to be drawn together to the boot thanks to a means for drawing together, made of a single continuous tie such as a strap (6) in supple material.

Abstract: A snowshoe (1) whose binding (5) for retaining of the boot is mounted on a cross-piece (9) whose ends are mounted laterally to the snowshoe itself, characterized in that the aforementioned ends are mounted via two couplings (7a, 7b) of two rings, namely a left coupling (7a) and a right coupling (7b).

Abstract: A snow shoe (1) includes a tubular frame (2) defining an interior zone. A deck (4) which is surrounded by the frame is made in part of a film (3). A binding (7) retained on the deck for securing the boot of the user. A central technical bottom piece (15) enhances the traction and floatation properties, as well as the comfort of the snowshoe (1). The central technical bottom piece (15) which is arranged along the central portion of the tubular frame (2) includes a traction surface having lateral longitudinal traction portions (18a, 18b) extending vertically from the frame (2), in this manner, the traction characteristics in the transverse direction are enhanced. The traction portions (18a, 18b) may comprise lateral walls, spikes, blades, or the like. The traction portions (18a, 18b) extend in the downward direction from the outer edge of the snowshoe rather than from the middle areas of the snowshoe (1) to increase the comfort of the shoe (1).

Abstract: A recombinant retrovirus capable of infecting a non-dividing cell and a method of producing such a virus is provided. The recombinant retrovirus is preferably of lentivirus origin and is useful for the treatment of a variety of disorders including neurological disorders and disorders of other non-dividing cells.

Abstract: A snowshoe (1) has a peripheral frame (2). A deck (4) extends across an interior of the peripheral frame and supports a binding (5) for retaining the boot of the user. The snowshoe has horizontal surfaces for supporting the snowshoe and the user on top of the snow and downward depending on traction members (3a, 3b, 50a, 50b) for engaging the snow to facilitate walking without slipping. The traction members are preferably disposed vertically and extend downward below a horizontal plane (H) of the deck. The traction members have regions of reduced height (100, 100a, 100b, 100c, 100d, 100e, 100f) relative to a forward portion (7a) of the traction members or the rearward portion (7c) of the traction members in a central zone (B) aligned with the region which receives and holds the user's boot (6).

Abstract: A snow shoe (1) has a peripheral frame (2) which defines an interior zone or screen (8). A retention device (3) retains a shoe (4) of a user on the snow shoe. The retention device includes a pivoting plate (7) which is articulated on the screen around a transverse pivoting axle (9), a front strap (10), arranged on the pivoting plate, and a positioning and a control mechanism which permits modification of the longitudinal position of the user's shoe. Specifically, the retention device permits positioning of the front or rear end of the shoe relative to the pivoting axle (7), or of the pivoting axle relative to the screen (8).