Abstract: The present invention relates to a method for estimating the effectiveness of treatment with an anti-CD20 agent in a patient with rheumatoid arthritis and who has had an inadequate response to at least one prior biotherapy, consisting in analysing a biological sample of said patient for the expression of a set of biomarkers, the results of which make it possible to determine whether said agent is a treatment that will engender a beneficial response for said patient. The present invention also relates to a system for estimating the effectiveness of said treatment in said patient comprising means for measuring or receiving data, the expression level of said biomarkers and means for processing these data configured to estimate said effectiveness of said treatment in said patient.

Abstract: The present invention relates to a method for estimating the effectiveness of treatment with an anti-TNF? agent in a patient with rheumatoid arthritis and who has had an inadequate response to at least one prior biotherapy, consisting in analysing a biological sample of said patient for the expression of a set of biomarkers, the results of which make it possible to determine whether said agent is a treatment that will engender a beneficial response for said patient. The present invention also relates to a system for estimating the effectiveness of said treatment in said patient comprising means for measuring or receiving data, the expression level of said biomarkers and means for processing these data configured to estimate said effectiveness of the treatment in said patient.

Abstract: A method for manufacturing a glass with a stem or with a base made of a plastic material, the glass including a receiving portion mounted over a base or over a stem, the method being implemented by a rotary tooling comprising a plurality of workstations and at least one mold wherein the method includes the following steps: a) forming of the receiving portion of the glass on at least one first workstation called injection station; b) overmolding of the stem or of the base over the receiving portion, in order to form a glass with a stem or with a base, the overmolding being carried out on at least one other workstation called overmolding station; c) ejection of the glass thus formed on the overmolding station or on another workstation called ejection station.

Abstract: The disclosure relates to a method for estimating the effectiveness of treatment with a T-lymphocyte cell co-stimulation modulator agent in a patient with rheumatoid arthritis and who has had an inadequate response to prior biotherapy, consisting in analysing a biological sample of said patient for the expression of a set of biomarkers, the results of which make it possible to determine whether said modulator agent is a treatment that will engender a beneficial response for said patient. The disclosure also relates to a system for estimating the effectiveness of said treatment in said patient comprising means for measuring or receiving data concerning the expression level of said biomarkers and means for processing these data configured to estimate said effectiveness of said treatment in said patient.

Abstract: An injection mold including at least one first station for the injection of a first portion of the part, at least one second station for the injection of a second portion of the part, a first loader including at least one first molding cavity, the first loader being movable at least in rotation between the first injection station and a first transfer and/or assembly area, a second loader including at least one first molding cavity, the second loader being movable at least in rotation between the second injection station and a second transfer and/or assembly area, wherein the injection mold includes at least one transfer loader, movable at least in rotation between the first transfer and/or assembly area and the second transfer and/or assembly area.

Abstract: An injection mold including at least one first mold portion, at least a second mold portion positioned facing the first mold portion, the first portion or the second portion of the mold being configured to be axially movable relative to respectively the second portion or the first mold portion between at least an opening position of the injection mold and a closing position of the injection mold, at least one first workstation called injection station, and at least a second workstation called insert laying station and/or an ejection station. An injection method implemented by the injection mold.

Abstract: An injection mold including at least one first mold portion, at least a second mold portion positioned facing the first mold portion, the first portion or the second portion of the mold being configured to be axially movable relative to respectively the second portion or the first mold portion between at least an opening position of the injection mold and a closing position of the injection mold, at least one first workstation called injection station, and at least a second workstation called insert laying station and/or an ejection station. An injection method implemented by the injection mold.

Abstract: An injection mold including at least one first station for the injection of a first portion of the part, at least one second station for the injection of a second portion of the part, a first loader including at least one first molding cavity, the first loader being movable at least in rotation between the first injection station and a first transfer and/or assembly area, a second loader including at least one first molding cavity, the second loader being movable at least in rotation between the second injection station and a second transfer and/or assembly area, wherein the injection mold includes at least one transfer loader, movable at least in rotation between the first transfer and/or assembly area and the second transfer and/or assembly area.

Abstract: Injection mold for manufacturing a piece, the mold including: at least one first mold body, at least one second mold body, first and second mold bodies being positioned facing each other, at least one first platen having at least partially at least one molding cavity intended for forming a half-piece of piece, the first platen being positioned between the first and the second mold bodies, at least one second platen having at least partially at least one molding cavity intended for forming a complementary half-piece of piece, second platen being positioned between first platen and the second mold body, the first platen being mounted at least in rotation on first mold body so as to move in at least one position in which the molding cavity first platen is positioned facing molding cavity of second platen, characterized in that the injection mold includes at least one movably mounted heating member.