Abstract: Methods for detecting the presence and/or assessing the severity of myocardial ischemia during pharmacologic stress tests by administration of a pharmaceutical composition comprising adenosine and dipyridamole are described. The methods allow for the combined administration of dipyridamole administered as a bolus with adenosine given as an infusion, where the dosages of each of these compounds are below their respective dosages when the compounds are used as a single agent. The methods are useful for exploiting the vasodilating abilities of adenosine at doses at which side effects related to adenosine are substantially reduced while optimal coronary artery perfusion is achieved. Also presented, are compositions, unit dosage forms, and kits that are useful in performing the methods.

Abstract: An aqueous, liquid or semi-liquid pharmaceutical or dietary composition, including at least one L-arginine salt on the basis of at least one gram of the salt per dosage unit. Adding the quantity of water necessary to dissolve an arginine salt, maltitol and, optionally, an alcohol or an alcoholate, ensures the removal of the bitterness from the liquid or semi-liquid compositions made from salified arginine. This specific composition allows considerable doses of arginine to be taken directly via oral administration, by drinking, without adding additional water. Also, a food composition containing a dietary composition as defined above.

Abstract: Methods for detecting the presence and/or assessing the severity of myocardial ischemia during pharmacologic stress tests by administration of a pharmaceutical composition comprising adenosine and dipyridamole are described. The methods allow for the combined administration of dipyridamole administered as a bolus with adenosine given as an infusion, where the dosages of each of these compounds are below their respective dosages when the compounds are used as a single agent. The methods are useful for exploiting the vasodilating abilities of adenosine at doses at which side effects related to adenosine are substantially reduced while optimal coronary artery perfusion is achieved. Also presented, are compositions, unit dosage forms, and kits that are useful in performing the methods.

Abstract: Methods are presented that comprise the administration of a pharmaceutical composition comprising adenosine and dipyridamole, as well methods comprising the combined administration of dipyridamole administered as a bolus with adenosine given as an infusion, both at dosages below their respective single agent dosages, for detecting the presence and/or assessing the severity of myocardial ischemia during pharmacologic stress tests. The methods are useful for exploiting the vasodilating abilities of adenosine at doses at which side effects related to adenosine are substantially reduced while optimal coronary artery perfusion is achieved. Also presented are compositions, unit dosage forms, and kits that are useful in performing the methods.

Abstract: Methods are presented that comprise the administration of a pharmaceutical composition comprising adenosine and dipyridamole, as well methods comprising the combined administration of dipyridamole administered as a bolus with adenosine given as an infusion, both at dosages below their respective single agent dosages, for detecting the presence and/or assessing the severity of myocardial ischemia during pharmacologic stress tests. The methods are useful for exploiting the vasodilating abilities of adenosine at doses at which side effects related to adenosine are substantially reduced while optimal coronary artery perfusion is achieved. Also presented are compositions, unit dosage forms, and kits that are useful in performing the methods.

Abstract: Methods are presented for concurrent or sequential administration of pharmaceutical compositions of adenosine, dipyridamole, or combinations thereof, at dosages below the respective single agent doses. Methods are provided for detecting the presence and/or assessing the severity of myocardial ischemia during pharmacologic stress tests. Methods include sequential administration of a dipyridamole bolus followed by intravenous infusion of adenosine and concurrent administration of adenosine and dipyridamole with or without dipyridamole pretreatment. The methods are useful for exploiting the vasodilating abilities of adenosine at doses at which side effects related to adenosine are substantially reduced while optimal coronary artery perfusion is achieved. Also presented are compositions, unit dosage forms, and kits that are useful in performing the methods.

Abstract: The present disclosure relates to compositions, methods, and kits using adenosine and inosine in combination for diagnosis and treatment.

Abstract: The invention concerns the association of an antagonist of &agr;-adrenergic receptors, for instance yohimbine, and a nitrogen monoxide donor, for instance arginine, with synergistic effect and useful for fighting against female sexual dysfunction.

Abstract: A composition which includes a purine, an NSAID, and a pharmaceutical excipient and/or vehicle. A method which treats male or female sexual dysfunction and includes administering a therapeutically effective amount of the composition to a person. A method which prevents male or female sexual dysfunction and includes administering a therapeutically effective amount of the composition to a person, and a method for increasing sexual desire and/or promoting sexual activity and/or increasing sexual capacities and/or promoting sexual activity and/or improving the intensity of sexual pleasure and/or promoting the attainment of satisfying sexual relations in persons not suffering from sexual dysfunctions and includes administering to a person a composition including a purine and an NSAID.

Abstract: A method which treats inflammation or thrombosis and includes administering to a mammal a therapeutically effective amount of a composition including a purine and an NSAID as active ingredients. A method which prevents inflammation or thrombosis and includes administering to a mammal a therapeutically effective amount of a composition including a purine and an NSAID as active ingredients. An anti-inflammatory or anti-thrombotic composition which includes one or more molecules of purine covalentlylinked to one or more molecules of NSAID, or optionally, by at least one spacer arm intermediary.

Abstract: A method for treating a human being having or suspected of having sexual dysfunction or a disorder of physiological and/or anatomical response to sexual stimulation, said dysfunction or disorder involving erectile tissue of genitalia comprising administering the nitrogen monoxide donor arginine and at least on nucleotide selected from the group consisting of AMP or ATP.