Abstract: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality worldwide. Acute exacerbation of COPD (AE-COPD) in patients are mostly due to respiratory infection and are associated with an inexorable decline in lung function, enhanced oedema as well as airway and systemic inflammation. Previous results show that treatment with anti-IL-20Rb blocking antibodies increased the bacterial clearance in control mice infected by S. pneumoniae and protected CS-exposed mice from bacterial infection, by decreasing the bacterial burden and the inflammatory infiltrate. Therefore there is an interest for generating monoclonal antibodies specific for IL-20Rb with a neutralizing activity for their use in the treatment of AE-COPD. The present invention fulfills this need by providing antibodies having specificity for IL-20Rb.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections. The increasing burden of antimicrobial resistance coupled with the decreasing number of antibiotics in development has urged for strategies to elaborate new therapies. The inventors showed a therapeutic effect of IL-20 receptor 10 antagonists in pulmonary bacterial infection mouse model. Indeed, they demonstrated that treatment with IL-20 receptor antagonists reduces bacterial burden, cellular infiltration and inflammation in bronchoalveolar lavage fluid (BALF) and lung. In particular, the present invention relates to an antagonist of IL-20 cytokines, or/and an antagonist of IL-20RB receptor for use in a method for the treatment of pulmonary bacterial infections in a subject in 15 need thereof.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acme exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of IL-20 cytokines.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections. The increasing burden of antimicrobial resistance coupled with the decreasing number of antibiotics in development has urged for strategies to elaborate new therapies. The inventors showed a therapeutic effect of IL-20 receptor 10 antagonists in pulmonary bacterial infection mouse model. Indeed, they demonstrated that treatment with IL-20 receptor antagonists reduces bacterial burden, cellular infiltration and inflammation in bronchoalveolar lavage fluid (BALF) and lung. In particular, the present invention relates to an antagonist of IL-20 cytokines, or/and an antagonist of IL-20RB receptor for use in a method for the treatment of pulmonary bacterial infections in a subject in 15 need thereof.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of a flagellin polypeptide.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of IL-20 cytokines.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of at least one NKT cell agonist.

Abstract: A guidance system and method is provided which is suitable for guiding a follower vehicle such that it follows a leader. It includes a system for localizing the leader relative to the follower vehicle. At least two distance measuring devices designed to be carried by the follower vehicle are provided, each being suitable for measuring a distance from a reference point of the follower vehicle, associated with the distance measuring device, to the leader. The reference points are spaced apart from one another, and a computer is provided which is, programmed to deduce the position of the leader relative to the follower vehicle from the distances measured by the measuring devices.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the invention relates to relates to a polypeptide selected from the group consisting of IL-22 polypeptides or IL-17 polypeptides for use in a method for the treatment of acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof.

Abstract: The guidance system (16) is suitable for guiding a follower vehicle (14) such that it follows a leader (12). It includes a system (20) for localizing the leader (12) relative to the follower vehicle (14). The localization system (20) includes: at least two distance measuring devices (23) designed to be carried by the follower vehicle (14), each being suitable for measuring a distance (D1, D2, D3) from a reference point (25, 26, 27) of the follower vehicle (14), associated with the distance measuring device (23), to the leader (12), said reference points (25, 26, 27) being spaced apart from one another, and a computer (28), programmed to deduce the position of the leader (12) relative to the follower vehicle (14) from the distances (D1, D2, D3) measured by the measuring devices (23). A corresponding guidance method is also provided.

Abstract: System, device and process for inspection of a thermal neutron absorption wall. The device comprises a fast neutron source and an arrangement for thermal neutron detection comprising at least one pair of oblong, substantially parallel thermal neutron detectors placed side by side, and substantially perpendicular to the direction of displacement of the device along the neutron absorption wall.

Abstract: The present invention relates to multistage vacuum collectors for ultra-high frequency tubes.Each electrode of the collector comprises two walls which are axially symmetrical with respect to the beam propagation axis and which are superimposed along said axis. The retarding path of the electrons due to the decreasing potentials of the electrodes is thus located in a small volume space between the facing walls of two adjacent electrodes. A plurality of permanent magnets positioned outside the vacuum enclosure above the final electrode produce an asymmetrical magnetic field with respect to the propagation axis.Application to travelling-wave tubes and klystrons.

Abstract: A microwave delay line, which has a periodic geometrical structure involving more particularly the repetition of first and second meshes so that the amplitude of the inverse mode of transmission is reduced compared with that of a helical line, which comprises rods made from a dielectric and good heat conducting material, arranged parallel to the line axis and regularly distributed over its periphery. These rods are equally subdivided into first and second groups, which are regularly distributed over the line periphery. The rods of the first group are brazed to the first meshes of the line and insulated from the second meshes and the rods of the second group are brazed to the second meshes of the line and insulated from the first meshes.