Patents by Inventor Philippe Guedat

Philippe Guedat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetracyclic inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
    Patent number: 7875613
    Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim 1.
    Type: Grant
    Filed: October 30, 2006
    Date of Patent: January 25, 2011
    Assignee: Hybrigenics SA
    Inventors: Philippe Guedat, Xavier Jacq, Frédéric Colland, Laurent Daviet, Etienne Formstecher, Jean-Christophe Rain, Matteo Colombo
  • Thiazolylimidazole derivatives and their use as inhibitors of microsomal triglyceride transfer protein
    Patent number: 7767819
    Abstract: The present invention relates to thiazolylimidazole derivatives of the general formula (I) in which: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3; and R1, R2, R3, R4, R5, R6, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
    Type: Grant
    Filed: January 17, 2005
    Date of Patent: August 3, 2010
    Assignee: Merck Patent GmbH
    Inventors: Philippe Guedat, Olivier Chevreuil, Thierry Convard
  • THIAZOLYLIMIDAZOLE DERIVATIVES AN THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN
    Publication number: 20100137601
    Abstract: The present invention relates to thiazolylimidazole derivatives of the general formula (I) in which: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3; and R1, R2, R3, R4, R5, R6, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
    Type: Application
    Filed: February 4, 2010
    Publication date: June 3, 2010
    Inventors: Philippe GUEDAT, Olivier Chevreuil, Thierry Convard
  • Aroyl-O-piperidine derivatives for the treatment of diabetes-related problems
    Patent number: 7723358
    Abstract: The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R1, R2, R3 and R4 are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: May 25, 2010
    Assignee: Merck Patent GmbH
    Inventors: Philippe Guedat, Francois Collonges, Olivier Chevreuil, Hervé Dumas, Marie Noelle Denault, Stéphane Yvon, Peter Kane, Julia Lainton, Avril Robertson, Bernd Wendt
  • Thiazolypiperidine derivatives as MTP inhibitors
    Patent number: 7674803
    Abstract: The present invention relates to thiazolylpiperidine derivatives of the general formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2?, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
    Type: Grant
    Filed: June 2, 2004
    Date of Patent: March 9, 2010
    Assignee: Merck Patent GmbH
    Inventors: Philippe Guèdat, Francois Collonges, Hervé Dumas, Jean-Yves Ortholand, Jacques Decerprit, Jaxques Barbanton, Robert J. Foster, Peter Kane, Bernd Went
  • NOVEL TETRACYCLIC INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20100048575
    Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use: Formula (I) wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim 1
    Type: Application
    Filed: October 25, 2007
    Publication date: February 25, 2010
    Inventors: Philippe Guedat, Xavier Jacq, Frédéric Colland, Laurent Daviet, Etienne Formstecher, Jean-Christophe Rain, Matteo Colombo
  • NOVEL CYSTEINE PROTEASE INHIBITORS AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20090215786
    Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
    Type: Application
    Filed: July 26, 2006
    Publication date: August 27, 2009
    Inventors: Philippe Guedat, Guillaume Boissy, Catherine Borg-Capra, Frederic Colland, Laurent Daviet, Etienne Formstecher, Xavier Jacq, Jean-Christophe Rain, Remi Delansorne, Stefania Vallese, Matteo Colombo
  • Novel Inhibitors of Cysteine Proteases, the Pharmaceutical Compositions Thereof and their Therapeutic Applications
    Publication number: 20090181972
    Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
    Type: Application
    Filed: December 5, 2006
    Publication date: July 16, 2009
    Inventors: Philippe Guedat, Guillaune Boissy, Catherine Borg-Capra, Frederic Colland, Laurent Daviet, Etienne Formstecher, Xavier Jacq, Jean-Christophe Rain, Remi Delansorne, Ilaria Peretto, Stefano Vignando
  • Inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
    Patent number: 7462615
    Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
    Type: Grant
    Filed: December 8, 2005
    Date of Patent: December 9, 2008
    Assignee: Hybrigenics SA
    Inventors: Philippe Guedat, Guillaume Boissy, Catherine Borg-Capra, Frédéric Colland, Laurent Daviet, Etienne Formstecher, Xavier Jacq, Jean-Christophe Rain, Rémi Delansorne, Ilaria Peretto, Stefano Vignando
  • Thiazolylimidazole Derivatives and Their Use as Inhibitors of Microsmal Triglyceride Transfer Protein
    Publication number: 20080214610
    Abstract: The present invention relates to thiazolylimidazole derivatives of the general formula (I) in which: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3; and R1, R2, R3, R4, R5, R6, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
    Type: Application
    Filed: January 17, 2005
    Publication date: September 4, 2008
    Inventors: Philippe Guedat, Olivier Chevreuil, Thierry Convard
  • NOVEL TETRACYCLIC INHIBITORS OF CYSTEINE PROTEASES, THE PHARMACEUTICAL COMPOSITIONS THEREOF AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20080103149
    Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use wherein R3, R4, R5, R6, Y, Het1, T, U, V, W, X, Ru, Rv and Rw are as defined in claim 1
    Type: Application
    Filed: October 30, 2006
    Publication date: May 1, 2008
    Inventors: Philippe GUEDAT, Xavier Jacq, Frederic Colland, Laurent Daviet, Etienne Formstecher, Jean-Christophe Rain, Matteo Colombo
  • Aroyl-O-Piperidine Derivatives for the Treatment of Diabetes-Related Problems
    Publication number: 20070254919
    Abstract: The present invention relates to derivatives of aroyl-O-piperidine structure of the general formula (I): in which R1, R2, R3 and R4 are as defined in the description. Application of the compounds of the formula (I) to the treatment of hyper-triglyceridaemia, hypercholesterolaemia and dyslipidaemia, and to the prevention or treatment of obesity.
    Type: Application
    Filed: May 19, 2005
    Publication date: November 1, 2007
    Inventors: Philippe Guedat, Francois Collonges, Olivier Chevreuil, Herve Dumas, Marie Denault, Stephane Yvon, Peter Kane, Julia Lainton, Avril Robertson, Bernd Wendt
  • Novel inhibitors of cysteine proteases, the pharmaceutical compositions thereof and their therapeutic applications
    Publication number: 20070135439
    Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 14, 2007
    Inventors: Philippe Guedat, Guillaume Boissy, Catherine Borg-Capra, Frederic Colland, Laurent Daviet, Etienne Formstecher, Xavier Jacq, Jean-Christophe Rain, Remi Delansorne, IIaria Peretto, Stefano Vignando
  • Diphenylamine derivatives
    Publication number: 20070129433
    Abstract: The invention relates to compounds of the formula (I) in which: i and j=1; R1 is in position 3 or 4 on the phenyl ring and represents a cyano group, an alkoxy group substituted by halogen, a thioalkyl group, an alkylcarbonyl group or an alkylsulfonyl group; and R2 represents a carboxyl group, an aikoxycarbonyl group, an alkylcarbonyl group, an unsubstituted amide group or a linear or branched alkyl group substituted by a cyano, hydroxyl, cabboxyl, aikoxycarbonyl or unsubstituted amide group; and also the pharmaceutically acceptable derivatives, salts, solvates and stereoisomers thereof, including mixtures thereof in all proportions.
    Type: Application
    Filed: November 17, 2004
    Publication date: June 7, 2007
    Inventors: Claude Lardy, Philippe Guedat, Lidia Caputo
  • Thiazolypiperidine derivatives as mtp inhibitors
    Publication number: 20070054939
    Abstract: The present invention relates to thiazolylpiperidine derivatives of the general formula (I): in which: A represents a radical chosen from the radicals a1 and a2 below: G represents a bond or a divalent radical chosen from the groups g1, g2 and g3 below: and R1, R2, R2?, R3, R4, R5, Y and Z are as defined in the description. Application of the compounds of the formula (I) to the treatment of hypertriglyceridaemia, hypercholesterolaemia and dyslipidaemia.
    Type: Application
    Filed: June 2, 2004
    Publication date: March 8, 2007
    Inventors: Philippe Guedat, Francois Collonges, Herve Dumas, Jean-Yves Ortholand, Jacques Decerprit, Jaxques Barbanton, Robert Foster, Peter Kane, Bernd Went
  • Novel cysteine protease inhibitors and their therapeutic applications
    Publication number: 20070032499
    Abstract: The present invention concerns new compounds of formula (I), their process of preparation and their therapeutic use.
    Type: Application
    Filed: August 5, 2005
    Publication date: February 8, 2007
    Inventors: Philippe Guedat, Guillaume Boissy, Catherine Borg-Capra, Frederic Colland, Laurent Daviet, Etienne Formstecher, Xavier Jacq, Jean-Christophe Rain, Rerni Delansorne, Stefania Vallese, Matteo Colombo
  • Novel compounds
    Publication number: 20050089493
    Abstract: Spermine:peptide-based surfactant compounds are disclosed. The compounds are based on a spermine backbone with peptide groups and optionally hydrocarbyl groups linked thereto. Uses of the spermine:peptide-based surfactant compounds and methods for their production are also disclosed.
    Type: Application
    Filed: November 17, 2004
    Publication date: April 28, 2005
    Inventors: Patrick Camilleri, Philippe Guedat, Anthony Kirby, Andreas Kremer
  • Compounds
    Patent number: 6835712
    Abstract: Spermine:peptide-based surfactant compounds are disclosed. The compounds are based on a spermine backbone with peptide groups and optionally hydrocarbyl groups linked thereto. Uses of the spermine:peptide-based surfactant compounds and methods for their production are also disclosed.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: December 28, 2004
    Assignees: SmithKline Beecham p.l.c., Cambridge University Technical Services Ltd.
    Inventors: Patrick Camilleri, Philippe Guedat, Anthony John Kirby, Andreas Kremer
  • Novel compounds
    Publication number: 20040138139
    Abstract: Diaminodicarboxylic acid:peptide gemini surfactant compounds are disclosed. Uses of the diaminodicarboxylic acid: peptide-based gemini surfactant compounds and methods for their production are also disclosed.
    Type: Application
    Filed: November 25, 2003
    Publication date: July 15, 2004
    Inventors: Patrick Camilleri, Anthony John Kirby, Christele Perrin, Gael Alain Bertrand Ronsin, Philippe Guedat