Abstract: Some aspect of this disclosure provide reversible MHC protein multimers, and methods of using such multimers in the detection and/or isolation of specific T-cells or T-cell populations. Because reversible MHC multimers can efficiently be dissociated, the time of MHC binding to T-cell receptors, and, thus, T-cell receptor-mediated T-cell activation can be minimized. The use of reversible MHC multimers as provided herein, accordingly, allows for the detection and isolation of bona fide antigen-specific CD8+ T cells without inducing activation dependent cell death, including rare, therapeutically valuable T-cells expressing T-cell receptors binding tumor antigens with high affinity. Methods for the production and use of reversible multimers are also provided.

Abstract: In an aspect, first interaction data characterizing a first interaction of a user with a mobile device configured to operate an application client can be received. A plurality of segments of users of the application client can be determined, and each of the plurality of segments can be associated with one or more settings that characterize an operating parameter of the application client. The user can be assigned to a first segment of the determined plurality of segments based on a correspondence between a characteristic of the user and a characteristic associated with the first segment. The application client can be modified based on the one or more settings associated with the first segment. The modified application client can be provided for interaction by the user via the mobile device. Related systems, apparatus, techniques, and articles are also described.

Abstract: In an aspect, first interaction data characterizing a first interaction of a user with a mobile device configured to operate an application client can be received. A plurality of segments of users of the application client can be determined, and each of the plurality of segments can be associated with one or more settings that characterize an operating parameter of the application client. The user can be assigned to a first segment of the determined plurality of segments based on a correspondence between a characteristic of the user and a characteristic associated with the first segment. The application client can be modified based on the one or more settings associated with the first segment. The modified application client can be provided for interaction by the user via the mobile device. Related systems, apparatus, techniques, and articles are also described.

Abstract: In an aspect, first interaction data characterizing a first interaction of a user with a mobile device configured to operate an application client can be received. A plurality of segments of users of the application client can be determined, and each of the plurality of segments can be associated with one or more settings that characterize an operating parameter of the application client. The user can be assigned to a first segment of the determined plurality of segments based on a correspondence between a characteristic of the user and a characteristic associated with the first segment. The application client can be modified based on the one or more settings associated with the first segment. The modified application client can be provided for interaction by the user via the mobile device. Related systems, apparatus, techniques, and articles are also described.

Abstract: Some aspects of this invention are based on the recognition that reversible protein multimers in which monomeric proteins are conjugated to a carrier molecule via chelation complex bonds are stable under physiological conditions and can be dissociated in a controlled manner under physiological, nontoxic conditions. Accordingly, such protein multimers are useful for a variety of in vitro, ex vivo, and in vivo application for research, diagnostics, and therapy. Some aspect of this invention provide reversible MHC protein multimers, and methods of using such multimers in the detection and/or isolation of specific T-cells or T-cell populations. Because reversible MHC multimers can efficiently be dissociated, the time of MHC binding to T-cell receptors, and, thus, T-cell receptor-mediated T-cell activation can be minimized.

Abstract: Some aspects of this invention are based on the recognition that reversible protein multimers in which monomeric proteins are conjugated to a carrier molecule via chelation complex bonds are stable under physiological conditions and can be dissociated in a controlled manner under physiological, nontoxic conditions. Accordingly, such protein multimers are useful for a variety of in vitro, ex vivo, and in vivo application for research, diagnostics, and therapy. Some aspect of this invention provide reversible MHC protein multimers, and methods of using such multimers in the detection and/or isolation of specific T-cells or T-cell populations. Because reversible MHC multimers can efficiently be dissociated, the time of MHC binding to T-cell receptors, and, thus, T-cell receptor-mediated T-cell activation can be minimized.

Abstract: Some aspects of this invention are based on the recognition that reversible protein multimers in which monomeric proteins are conjugated to a carrier molecule via chelation complex bonds are stable under physiological conditions and can be dissociated in a controlled manner under physiological, nontoxic conditions. Accordingly, such protein multimers are useful for a variety of in vitro, ex vivo, and in vivo application for research, diagnostics, and therapy. Some aspect of this invention provide reversible MHC protein multimers, and methods of using such multimers in the detection and/or isolation of specific T-cells or T-cell populations. Because reversible MHC multimers can efficiently be dissociated, the time of MHC binding to T-cell receptors, and, thus, T-cell receptor-mediated T-cell activation can be minimized.

Abstract: A device for digitally producing signals representative of sounds having a sonority simulating that of an instrument with keyboard and strings that are linked to a sounding board of the instrument, these sounds each corresponding to a note of the instrument. The device produces at least one signal representative of a keyboard and stringed instrument sound on the basis of at least one trigger signal and parameters, termed physical parameters. The physical parameters include at least one parameter, the so-called sounding-board parameter, characteristic of a sounding board of a keyboard and stringed instrument to be simulated. Furthermore, the physical parameters according to the invention comprise at least one parameter, termed the string(s) parameter, characteristic of at least one string of the keyboard and stringed instrument to be simulated. The device includes elements (9, 10, 11, 33) for inputting at least one physical parameter.

Abstract: A device for digitally producing signals representative of sounds having a sonority simulating that of an instrument with keyboard and strings that are linked to a sounding board of the instrument, these sounds each corresponding to a note of the instrument. The device produces at least one signal representative of a keyboard and stringed instrument sound on the basis of at least one trigger signal and parameters, termed physical parameters. The physical parameters include at least one parameter, the so-called sounding-board parameter, characteristic of a sounding board of a keyboard and stringed instrument to be simulated. Furthermore, the physical parameters according to the invention comprise at least one parameter, termed the string(s) parameter, characteristic of at least one string of the keyboard and stringed instrument to be simulated. The device includes elements (9, 10, 11, 33) for inputting at least one physical parameter.

Abstract: The invention relates to immunoconjugates of formula: A-B—(C)n where B may be present or absent, A is a specific binding protein such as an antibody or an antibody binding fragment, or a ligand binding to a receptor present on target cells B comprises at least one molecule to which “A” and “C” bind, such as an avidin/streptavidin complex, “C” is an MHC molecule, and “n” is a whole number ranging from 1 to 10. The conjugates provide the exquisite binding specificity of antibodies, combined with an ability to stimulate cytotoxic T cells to identify and to destroy cells on which the conjugate is bound and oligomerized. The conjugates are useful both therapeutically and diagnostically.

Abstract: A digital signal processor is designed to execute variable-sized instructions that may include up to N elementary instruction codes. The processor comprises a memory program comprising I individually addressable, parallel-connected memory banks in which the codes of a program are recorded in an interlaced fashion, and a circuit for reading the program memory arranged to read a code in each of the I memory banks during a cycle for reading an instruction. A cycle for reading an instruction in the program memory includes reading a sequence of codes that includes the instruction code or codes to be read and can also include codes, belonging to a following instruction, that are filtered before the instruction is applied to execution units. The program memory of the digital signal processor does not include any no-operation type codes.

Abstract: The invention relates to immunoconjugates of formula:

Abstract: To package liquids in thin-walled packages while at the same time conferring good mechanical strength upon these packages, an inert gas such as nitrogen and/or carbon dioxide, in the gaseous state is or are introduced into the liquid by means of an injector (22), the liquid becoming saturated or supersaturated with which gas(es); the product obtained is stored in a reservoir (14) at a constant level above which an overhead of the said gas is created at a raised pressure which is constant by virtue of regulating means (3). On demand, this product is transferred, by tapping means (4), to packages which are partially filled with product the surface of which is surmounted with an overhead of the said gas at a raised pressure after the package has been sealed.

Abstract: A method for prioritized data transmission to a common transmission medium from a plurality of interface modules coupled to it, for interfacing at least one input bitstream with said common transmission medium, whereby access is arbitrated on the basis of a module priority of each interface module, is such that, for at least one interface module, the module priority is dependent on at least one connection parameter associated to packets of said at least one input bitstream. An arrangement for performing this method is described as well as several variant implementations of the method and the arrangement.

Abstract: A plant for transferring a gas in the gaseous or liquified state into a liquid. The plant includes a pressurized-gas circuit (2) having a device (21, 22) for injecting gas in the gaseous or liquid state into a liquid, a chamber (13) for mixing the gas with the liquid, the chamber located downstream of the gas injection device and having an outlet connected to the overhead of a buffer tank (14) in order to introduce, into the latter, liquid, in the form of droplets or streams, with which the gas is mixed, and a mechanism (15) for withdrawing the liquid/gas mixture from the tank. The plant may be used for the carbonation of consumable liquids.

Abstract: A method for prioritised data transmission to a common transmission medium from a plurality of interface modules coupled to it, for interfacing at least one input bitstream with said common transmission medium, whereby access is arbitrated on the basis of a module priority of each interface module, is such that, for at least one interface module, the module priority is dependent on at least one connection parameter associated to packets of said at least one input bitstream. An arrangement for performing this method is described as well as several variant implementations of the method and the arrangement.

Abstract: A digital signal processor is designed to execute variable-sized instructions that may include up to N elementary instruction codes. The processor comprises a memory program comprising I individually addressable, parallel-connected memory banks in which the codes of a program are recorded in an interlaced fashion, and a circuit for reading the program memory arranged to read a code in each of the I memory banks during a cycle for reading an instruction. A cycle for reading an instruction in the program memory includes reading a sequence of codes that includes the instruction code or codes to be read and can also include codes, belonging to a following instruction, that are filtered before the instruction is applied to execution units. The program memory of the digital signal processor does not include any no-operation type codes.

Abstract: To obtain rapid transfer by means of a compact plant, the latter comprises a pressurized-gas circuit (2) which includes a device (21, 22) for injecting gas in the gaseous or liquid state and emerging in a liquid circuit which includes, downstream of the injection device,

Abstract: A plant for liquid-phase filtration of a cryogenic fluid comprising, in an ambient environment:a supply of a cryogenic fluid in liquid phase;a filtration component arranged between an inlet for feeding the cryogenic fluid and an outlet for use of the filtered cryogenic fluid, in which the filtration component filters microorganisms and/or particles and causes a head loss which is less than that which converts liquid phase to a solid or gaseous phase.

Abstract: An access control method to control access to a communication channel of a plurality of units coupled to it, each unit having a first and a second own priority assigned to it, includes a first step of comparing and withdrawing units, based on the first own priorities of said units, and for these units that have not withdrawn after the first step, this first step is repeated but using the second own priorities of these remaining units. A method to control access to a communication channel interconnecting a multitude of pluralities of units coupled to it, includes the mentioned steps for a single plurality for at least one plurality amongst said multitude.