Patents by Inventor Philippe Holzmuller

Philippe Holzmuller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antigenic structure and uses thereof for screening trypanosomiases in humans and animals
    Patent number: 9201070
    Abstract: The invention relates to an antigenic structure that contains a tryptophan epitope, characterised in that said structure is made up of a tryptophan pattern W or a peptide of 3 or 4 amino acids comprising a pattern W, coupled with glutaraldehyde. The invention can he used for screening trypanosomiasis in humans or animals.
    Type: Grant
    Filed: April 13, 2011
    Date of Patent: December 1, 2015
    Assignee: CENTRE DE COOPERATION INTERNATIONALE EN RECHERCHE AGRONOMIQUE POUR LE DEVELOPMENT (CIRAD)
    Inventors: Philippe Holzmuller, Silla Semballa, Philippe Vincendeau, Gerard Cuny
  • NOVEL AGENTS FOR THE PREVENTION OF LEISHMANIASIS
    Publication number: 20140193452
    Abstract: The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of Leishmania, said nucleic acids responding to one of the sequences SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5 et SEQ ID NO:11 and coding for a protein respectively exhibiting a sequence SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10 et SEQ ID NO:12. The invention can be used for over-expression of the genes of Leishmania coding for an excretion/secretion antigen.
    Type: Application
    Filed: November 4, 2013
    Publication date: July 10, 2014
    Inventors: JEAN-LOUP LEMESRE, MIREILLE CAVALEYRA, DENIS SERENO, PHILIPPE HOLZMULLER
  • Agents for the prevention of
    Patent number: 8574598
    Abstract: The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of Leishmania, said nucleic acids responding to one of the sequences SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5 et SEQ ID No. 11 and coding for a protein respectively exhibiting a sequence SEQ ID No. 6, SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10 et SEQ ID No. 12. The invention can be used for over-expression of the genes of Leishmania coding for an excretion/secretion antigen.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: November 5, 2013
    Assignee: Institut de Recherche Pour le Developpement (IRD)
    Inventors: Jean-Loup Lemesre, Mireille Cavaleyra, Denis Sereno, Philippe Holzmuller
  • ANTIGENIC STRUCTURE AND USES THEREOF FOR SCREENING TRYPANOSOMIASES IN HUMANS AND ANIMALS
    Publication number: 20130203085
    Abstract: The invention relates to an antigenic structure that contains a tryptophan epitope, characterised in that said structure is made up of a tryptophan pattern W or a peptide of 3 or 4 amino acids comprising a pattern W, coupled with glutaraldehyde. The invention can he used for screening trypanosomiasis in humans or animals.
    Type: Application
    Filed: April 13, 2011
    Publication date: August 8, 2013
    Applicant: Institut de Recherche pour le Developpment (IRD)
    Inventors: Philippe Holzmuller, Silla Semballa, Philippe Vincendeau, Gerard Cuny
  • Means for obtaining avirulent promastigotes, promastigotes obtained, and the applications thereof
    Patent number: 8187870
    Abstract: The invention relates to an expression vector of a gene coding for an antigenic protein of Leishmania promastigote, characterized in that it comprises a PSA gene insert in opposite orientation. The invention can be applied to the development of mutants under-expressing, or no longer expressing, genes coding for an antigenic protein of Leishmania promastigote, and to the therapeutic and/or vaccine-oriented uses thereof.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: May 29, 2012
    Assignee: Institut de Recherche pour le Developpement (IRD)
    Inventors: Jean-Loup Lemesre, Philippe Holzmuller, Rachel Bras-Gonçalves
  • Means for Obtaining Avirulent Leishmania Promastigotes, Promastigotes Obtained, and the Applications Thereof
    Publication number: 20090214595
    Abstract: The invention relates to an expression vector of a gene coding for an antigenic protein of Leishmania promastigote, characterised in that it comprises a PSA gene insert in opposite orientation. The invention can be applied to the development of mutants under-expressing, or no longer expressing, genes coding for an antigenic protein of Leishmania promastigote, and to the therapeutic and/or vaccine-oriented uses thereof.
    Type: Application
    Filed: February 10, 2006
    Publication date: August 27, 2009
    Applicant: INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT (IRD)
    Inventors: Jean-Loup Lemesre, Philippe Holzmuller, Rachel Bras-Goncalves
  • Novel Agents for the Prevention of Leishmaniosis
    Publication number: 20080026467
    Abstract: The invention relates to nucleic acid constructions, characterized in that they comprise nucleic acids which are isolated in the sense position and which are capable of coding for an immunogenic protein of promastigotes or amastigotes of Leishmania, said nucleic acids responding to one of the sequences SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID No. 4, SEQ ID No. 5 et SEQ ID No. 11 and coding for a protein respectively exhibiting a sequence SEQ ID No. 6, SEQ ID No. 7, SEQ ID No. 8, SEQ ID No. 9, SEQ ID No. 10 et SEQ ID No. 12. The invention can be used for over-expression of the genes of Leishmania coding for an excretion/secretion antigen.
    Type: Application
    Filed: November 19, 2004
    Publication date: January 31, 2008
    Inventors: Jean-Loup Lemesre, Mireille Cavaleyra, Denis Sereno, Philippe Holzmuller