Patents by Inventor Philippe JAÏS

Philippe JAÏS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230265479
    Abstract: The present invention concerns a method for expressing a recombinant DNA molecule in a eukaryotic host cell, comprising the steps of: (a) expressing or introducing at least one chimeric protein, in said host cell, wherein said chimeric protein comprises: (i) at least one catalytic domain of a capping enzyme, in particular selected in the group consisting of cap-0 canonical capping enzymes, cap-0 non-canonical capping enzymes, cap-1 capping enzymes and cap-2 capping enzymes; and (ii) at least one catalytic domain of a DNA-dependent RNA polymerase, in particular a bacteriophage DNA-dependent RNA polymerase, (b) constitutively or transiently downregulating the phosphorylation level of subunit a of translation initiation factor eIF2 (eIF2?) in said host cell.
    Type: Application
    Filed: August 3, 2021
    Publication date: August 24, 2023
    Applicant: EUKARYS
    Inventor: Philippe JAIS
  • Publication number: 20200165585
    Abstract: The present invention relates to a chimeric enzyme comprising or consisting of at least one catalytic domain of a capping enzyme and at least one RNA-binding domain of a protein-RNA tethering system as well as its application for the production of an RNA molecule with a 5?-terminal cap.
    Type: Application
    Filed: July 27, 2018
    Publication date: May 28, 2020
    Inventor: Philippe JAÏS
  • Publication number: 20170354706
    Abstract: The invention relates to a hybrid proteinaceous molecule comprising at least two proteins capable of inhibiting the activity of at least one antibiotic, the proteins each having different biochemical properties and being bonded to one another. The hybrid proteinaceous molecule inhibits the activity of a least one antibiotic in order to reduce the intestinal side effects of antibiotics, such as severe diarrhoea caused by the antibiotics, and nosocomial infections secondary to parenteral antibiotic therapy.
    Type: Application
    Filed: October 13, 2015
    Publication date: December 14, 2017
    Inventors: Daniel DUPRET, Mathieu SCHUE, Philippe JAIS