Abstract: The invention provides crystalline forms of 2?-(7,7-dimethyl-1?H,7H-spiro[furo[3,4-b]pyridine-5,4?-piperidin]-1?-yl)-1,3-dihydro-4?H-spiro[indene-2,5?-[1,3]oxazol]-4?-one, and a process for converting Form A to Form B for use in medicaments for treatment of anxiety, depression, irritability, impaired social interactions and psychomotor coordination, and other indications. The invention further provides processes to manufacture 2?-(7,7-dimethyl-1?H,7H-spiro[furo[3,4-b]pyridine-5,4?-piperidin]-1?-yl)-1,3-dihydro-4?H-spiro[indene-2,5?-[1,3]oxazol]-4?-one. Also disclosed are compounds useful as intermediates in the methods of the invention.

Abstract: A method of operation of a complex system includes obtaining a population of operating points in a multidimensional space having axes, each representative of a parameter of a subsystem of the system that is represented for characterization purposes; followed by constructing a plurality of limit domains in that space, each constructed around a reference point to encompass a proportion of the population defined in the subsystem plane under consideration, which plane corresponds to a projection of the operating points obtained at system level into the plane of the subsystem under consideration; followed, for each subsystem, by defining qualifying domains by counting points of the population lying outside a given limit; and as functions of the result of the counting and a target proportion for the population defined for the system, adapting the domain to define modified domains characterizing operation of the subsystems approaching a defined target for the system.

Abstract: The present invention relates to a deployable diverging bell (2) for a thruster, the bell comprising: a stationary first diverging bell portion (3) suitable for being connected to a stationary support of the thruster (1); a movable second diverging bell portion (4) that is movable between a retracted position and a deployed position in which it is connected to the downstream end of the first diverging bell portion (3) in order to extend it (3); and at least one deployment mechanism (6, 8) including means (6) for moving the movable second diverging bell portion (4) relative to the stationary first diverging bell portion (3) in order to deploy the movable second diverging bell portion (4) from its retracted position to its deployed position; the bell being characterized in that it includes at least one damper means (13) for damping vibration coming from the movable second diverging bell portion (4) and/or the deployment mechanism (6, 8).

Abstract: An injection element for injecting two propellants into a combustion chamber, and usable for a rocket engine including at least one combustion chamber of type having an injector including one or more such injection elements. The injection element includes a first annular duct for injecting a first propellant and a second annular duct for injecting a second propellant, the second duct being coaxial with and externally adjacent to the first duct, and potentially a third annular duct that is coaxial with and externally adjacent to the second duct. The first duct surrounds a central body of the injection element, the central body including a cavity in communication with an outer surface of the central body and configured to damp at least one predetermined acoustic frequency.

Abstract: The present invention relates to a deployable diverging bell (2) for a thruster, the bell comprising: a stationary first diverging bell portion (3) suitable for being connected to a stationary support of the thruster (1); a movable second diverging bell portion (4) that is movable between a retracted position and a deployed position in which it is connected to the downstream end of the first diverging bell portion (3) in order to extend it (3); and at least one deployment mechanism (6, 8) including means (6) for moving the movable second diverging bell portion (4) relative to the stationary first diverging bell portion (3) in order to deploy the movable second diverging bell portion (4) from its retracted position to its deployed position; the bell being characterized in that it includes at least one damper means (13) for damping vibration coming from the movable second diverging bell portion (4) and/or the deployment mechanism (6, 8).