Abstract: The invention provides CARs (CARs) that specifically bind to BCMA (B-Cell Maturation Antigen). The invention further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The invention further relates to therapeutic methods for use of these CARs and engineered immune cells for the treatment of a condition associated with malignant cells expressing BCMA (e.g., cancer).

Abstract: A radial tire (1) for an agricultural vehicle, which tire has a speed index at least equal to D for a maximum speed equal to 65 km/h, has a load index at least equal to 140 and at most equal to 170, and has a tread pattern comprising lugs with a radial height at least equal to 45 mm, having a crown reinforcement (3), consisting of 3 crown layers (31, 32, 33), each having reinforcing elements made of PET having an ultimate tensile strength at least equal to 32 daN, and the angles ANT1 and ANT3 of the reinforcing elements of the radially inner and outer layers (31, 33) with the circumferential direction have the same orientation and are less than 20°, and the angle ANT2 of the reinforcing elements of the median layer (32) with the circumferential direction has an opposite orientation to ANT1 and is greater than 10° plus the absolute value of the average of ANT1 and ANT3.

Abstract: A tire (1) for a sprayer-type agricultural vehicle, which has a speed index at least equal to D for a maximum speed equal to 65 km/h, which tire is intended to be mounted on a rim with a diameter at least equal to 42 inches, the maximum use pressure of which is at least equal to 3.2 bar and the load index of which is at least equal to 170. The Tire has a crown reinforcement (3) having at most 4 crown layers (31, 32, 33, 34), each having reinforcing elements with a tensile breaking force at least equal to 32 daN and having an aramid strand and a nylon or PET textile fibre strand, the aramid strand having a tensile breaking force at least equal to 30 daN.

Abstract: A radial tire (1) for an agricultural vehicle, which has a speed index at least equal to D for a maximum speed equal to 65 km/h, the authorized inflation pressure of which during use on loose ground is less than or equal to 1 bar and the load index of which is at least equal to 158, the tread pattern of which comprises lugs with a radial height at least equal to 45 mm, having a crown reinforcement (3) with at most 4 crown layers (31, 32, 33, 34), each having reinforcing elements having a tensile breaking force at least equal to 32 daN and having an aramid strand and a nylon or PET textile fibre strand, the aramid strand having a tensile breaking force at least equal to 30 daN.

Abstract: A tire comprising a crown reinforcement formed from at least two working crown layers and from at least one layer of circumferential reinforcing elements positioned radially between two working crown layers, the working crown layers adjacent to the layer of circumferential reinforcing elements being on each side of the equatorial plane and in the axial continuation of the layer of circumferential reinforcing elements coupled over an axial width, in order thereafter to be decoupled. A first additional layer of polymer blend having a width at least equal to the width 1 of the coupling zone and having a maximum thickness of less than two times the thickness of the layer of circumferential reinforcing elements is positioned radially under the working crown layer radially adjacent to and inside the layer of circumferential reinforcing elements and is at least partially radially superposed on the coupling zone of the working crown layers.

Abstract: A tire comprising at least two working layers and at least one layer of circumferential reinforcing elements. The layer of circumferential reinforcing elements comprises at least a central part and two axially exterior parts, the elastic modulus of the rubber compound with which the circumferential reinforcing elements of the central part are coated being less than the modulus of the rubber compound with which the circumferential reinforcing elements of the axially exterior parts are coated.

Abstract: A tire with a radial carcass reinforcement, wherein the reinforcing elements of at least one layer of the carcass reinforcement are non-wrapped three-layered metal cords with an unsaturated external layer which in what is referred to as the permeability test return a mean flow rate less than 4 cm3/min and at least 2 points of zero flow rate over a length of 2 cm.

Abstract: A tire with a radial carcass reinforcement, wherein the ratio of the axial width L of the tread to the maximum axial width S of the tire is strictly greater than 0.85 and the reinforcing elements of at least one layer of the carcass reinforcement are non-wrapped metal cords with saturated layers, at least one inner layer being sheathed with a layer made up of a polymeric composition such as a composition of non-crosslinkable, crosslinkable or crosslinked rubber, preferably based on at least one diene elastomer.

Abstract: Tire (10) for a heavy goods vehicle comprising a radial carcass reinforcement (60) anchored in each of the beads (50) to an anchoring structure (700), comprising a circumferential reinforcement (70), the carcass reinforcement (60) being partially wrapped around the anchoring structure (700), the tire (10) also comprising a coupling reinforcement (150) comprising a first part (151) in contact with the carcass reinforcement (60) and being extended by a second part (152) in contact with the anchoring structure (700) as far as a point (157) radially on the outside of the anchoring structure (700), located axially between the axially inner-most point (702) and the axially outermost point (704) of the anchoring structure (700), the tire (10) also comprising a stiffening reinforcement (160) surrounding the coupling reinforcement (150) and running radially on the inside of the anchoring structure (700) and of the coupling reinforcement (150), in which the axially outside end point (166) of said stiffening reinforceme

Abstract: A tire comprising at least two working layers and at least one layer of reinforcing elements. The layer of circumferential reinforcing elements comprises at least a central part and two axially exterior parts, the extent to which the circumferential reinforcing elements of the central part are penetrated by the rubber compound with which they are coated being less than the extent to which the circumferential reinforcing elements of the axially exterior parts are penetrated by the rubber compound with which they are coated.

Abstract: Tire (10) for a heavy goods vehicle comprising a radial carcass reinforcement (60) anchored in each of the beads (50) to an anchoring structure (700), comprising a circumferential reinforcement (70), the carcass reinforcement (60) being partially wrapped around the anchoring structure (700), the tire (10) also comprising a coupling reinforcement (150) comprising a first part (151) in contact with the carcass reinforcement (60) and being extended by a second part (152) in contact with the anchoring structure (700) as far as a point (157) radially on the outside of the anchoring structure (700), located axially between the axially innermost point (702) and the axially outermost point (704) of the anchoring structure (700), the tire (10) also comprising a stiffening reinforcement (160) surrounding the coupling reinforcement (150) and running radially on the inside of the anchoring structure (700) and of the coupling reinforcement (150), wherein the axially outside end point (166) of said stiffening reinforcement

Abstract: A tire with a radial carcass reinforcement comprising a crown reinforcement formed from at least two working crown layers of inextensible reinforcing elements and from at least one layer of circumferential reinforcing elements positioned radially between two working crown layers, the working crown layers adjacent to the layer of circumferential reinforcing elements being on each side of the equatorial plane and in the axial continuation of the layer of circumferential reinforcing elements coupled over an axial width, in order thereafter to be decoupled. A layer of polymer blend having a thickness greater than 1.5 mm over an axial width greater than 0.1×d is positioned axially between the axially exterior end of the layer of circumferential reinforcing elements and the axially interior end of the coupling zone of the working crown layers.

Abstract: A tire comprising at least two working layers and at least one layer of circumferential reinforcing elements positioned radially between two working crown layers. At least one layer of circumferential reinforcing elements has an axial width greater than 0.5×S, and is made up of two parts separated axially from one another, and, axially between the two parts of the layer of circumferential reinforcing elements, two working crown layers are coupled over an axial width greater than 0.035×S.

Abstract: Tyre (10) for a heavy goods vehicle comprising a radial carcass reinforcement (60) anchored in each of the beads (50) to an anchoring structure (700), comprising a circumferential reinforcement (70), the carcass reinforcement (60) being partially wrapped around the anchoring structure (700), the tyre (10) also comprising a coupling reinforcement (150) comprising a first part (151) in contact with the carcass reinforcement (60) and being extended by a second part (152) in contact with the anchoring structure (700) as far as a point (157) radially on the outside of the anchoring structure (700), located axially between the axially inner-most point (702) and the axially outermost point (704) of the anchoring structure (700), the tyre (10) also comprising a stiffening reinforcement (160) surrounding the coupling reinforcement (150) and running radially on the inside of the anchoring structure (700) and of the coupling reinforcement (150), in which the axially outside end point (166) of said stiffening reinforceme

Abstract: Tyre (10) for a heavy goods vehicle comprising a radial carcass reinforcement (60) anchored in each of the beads (50) to an anchoring structure (700), comprising a circumferential reinforcement (70), the carcass reinforcement (60) being partially wrapped around the anchoring structure (700), the tyre (10) also comprising a coupling reinforcement (150) comprising a first part (151) in contact with the carcass reinforcement (60) and being extended by a second part (152) in contact with the anchoring structure (700) as far as a point (157) radially on the outside of the anchoring structure (700), located axially between the axially innermost point (702) and the axially outermost point (704) of the anchoring structure (700), the tyre (10) also comprising a stiffening reinforcement (160) surrounding the coupling reinforcement (150) and running radially on the inside of the anchoring structure (700) and of the coupling reinforcement (150), wherein the axially outside end point (166) of said stiffening reinforcement

Abstract: A tire comprising a crown reinforcement formed from at least two working crown layers and from at least one layer of circumferential reinforcing elements positioned radially between two working crown layers, the working crown layers adjacent to the layer of circumferential reinforcing elements being on each side of the equatorial plane and in the axial continuation of the layer of circumferential reinforcing elements coupled over an axial width, in order thereafter to be decoupled. A first additional layer of polymer blend having a width at least equal to the width I of the coupling zone and having a maximum thickness of less than two times the thickness of the layer of circumferential reinforcing elements is positioned radially under the working crown layer radially adjacent to and inside the layer of circumferential reinforcing elements and is at least partially radially superposed on the coupling zone of the working crown layers.

Abstract: A tire with a radial carcass reinforcement comprising a crown reinforcement formed from at least two working crown layers of inextensible reinforcing elements and from at least one layer of circumferential reinforcing elements positioned radially between two working crown layers, the working crown layers adjacent to the layer of circumferential reinforcing elements being on each side of the equatorial plane and in the axial continuation of the layer of circumferential reinforcing elements coupled over an axial width, in order thereafter to be decoupled. A layer of polymer blend having a thickness greater than 1.5 mm over an axial width greater than 0.1×d is positioned axially between the axially exterior end of the layer of circumferential reinforcing elements and the axially interior end of the coupling zone of the working crown layers.

Abstract: A tire comprising at least two working layers and at least one layer of circumferential reinforcing elements. The layer of circumferential reinforcing elements comprises at least a central part and two axially exterior parts, the elastic modulus of the rubber compound with which the circumferential reinforcing elements of the central part are coated being less than the modulus of the rubber compound with which the circumferential reinforcing elements of the axially exterior parts are coated.

Abstract: A tire comprising at least two working layers and at least one layer of circumferential reinforcing elements positioned radially between two working crown layers. At least one layer of circumferential reinforcing elements has an axial width greater than 0.5×S, and is made up of two parts separated axially from one another, and, axially between the two parts of the layer of circumferential reinforcing elements, two working crown layers are coupled over an axial width greater than 0.035×S.

Abstract: A tire comprising at least two working layers and at least one layer of reinforcing elements. The layer of circumferential reinforcing elements comprises at least a central part and two axially exterior parts, the extent to which the circumferential reinforcing elements of the central part are penetrated by the rubber compound with which they are coated being less than the extent to which the circumferential reinforcing elements of the axially exterior parts are penetrated by the rubber compound with which they are coated.