Abstract: The present invention relates to a method for determining a karstic region modified by karstification phenomena. This method comprises, from a geological model, determining a seed cell and a target cell in that model. If a distance between the seed cell and the target cell is above a given distance, it is possible to update the seed cell with a bifurcation cell based at least on the coordinates of the seed cell, the coordinates of the target cell, a distance distribution, an angular distribution, and to re-iterate the test. Based on that bifurcation cells, trajectory is computed and cells of that trajectory is updated with new cell characteristics.

Abstract: The present invention relates to a method for determining a karstic region modified by karstification phenomena. This method comprises, from a geological model, determining a seed cell and a target cell in that model. If a distance between the seed cell and the target cell is above a given distance, it is possible to update the seed cell with a bifurcation cell based at least on the coordinates of the seed cell, the coordinates of the target cell, a distance distribution, an angular distribution, and to re-iterate the test. Based on that bifurcation cells, trajectory is computed and cells of that trajectory is updated with new cell characteristics.

Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The compounds of the invention inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Abstract: The present invention relates to a roof adapted to cover a manure storage tank. The roof comprises a plurality of trusses and sheeting members. The roof is constructed so as to minimize the lateral forces on the manure storage tank and to eliminate vertical forces on the centre point of the floor of the storage tank.

Abstract: The 5,6-dihydronaphthalenyl derivatives of the formulae possess potent retinoid-like activity against dermatological diseases with a substantially reduced irritancy profile when administered topically.