Patents by Inventor Philippe Louis Leboulch

Philippe Louis Leboulch has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic retroviral vectors for gene therapy
    Patent number: 11701435
    Abstract: Provided are improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells. Also provided are improved gene therapy methods for treating hematopoietic-related disorders. Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.
    Type: Grant
    Filed: March 16, 2020
    Date of Patent: July 18, 2023
    Assignees: bluebird bio, Inc., Massachusetts Institute of Technology
    Inventors: Philippe Louis Leboulch, Robert Pawliuk, Karen Westerman
  • THERAPEUTIC RETROVIRAL VECTORS FOR GENE THERAPY
    Publication number: 20200368370
    Abstract: Provided are improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells. Also provided are improved gene therapy methods for treating hematopoietic-related disorders. Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.
    Type: Application
    Filed: March 16, 2020
    Publication date: November 26, 2020
    Applicants: bluebird bio, Inc., Massachusetts Institute of Technology
    Inventors: Philippe Louis LEBOULCH, Robert PAWLIUK, Karen WESTERMAN
  • Therapeutic retroviral vectors for gene therapy
    Patent number: 10632212
    Abstract: The invention provides improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells. The invention further provides improved gene therapy methods for treating hematopoietic-related disorders. Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: April 28, 2020
    Assignees: bluebird bio, Inc., Massachusetts Institute of Technology
    Inventors: Philippe Louis Leboulch, Robert Pawliuk, Karen Westerman
  • THERAPEUTIC RETROVIRAL VECTORS FOR GENE THERAPY
    Publication number: 20190038775
    Abstract: Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.
    Type: Application
    Filed: September 13, 2018
    Publication date: February 7, 2019
    Applicants: bluebird bio, Inc., Massachusetts Institute of Technology
    Inventors: Philippe Louis Leboulch, Robert Pawliuk, Karen Westerman
  • Therapeutic retroviral vectors for gene therapy
    Patent number: 10105451
    Abstract: The invention provides improved compositions and methods for achieving gene therapy in hematopoietic cells and hematopoietic precursor cells, including erythrocytes, erythroid progenitors, and embryonic stem cells. The invention further provides improved gene therapy methods for treating hematopoietic-related disorders. Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.
    Type: Grant
    Filed: April 29, 2015
    Date of Patent: October 23, 2018
    Assignees: bluebird bio, Inc., Massachusetts Institute of Technology
    Inventors: Philippe Louis Leboulch, Robert Pawliuk, Karen Westerman
  • THERAPEUTIC RETROVIRAL VECTORS FOR GENE THERAPY
    Publication number: 20160022839
    Abstract: Retroviral gene therapy vectors that are optimized for erythroid specific expression and treatment of hemoglobinopathic conditions are disclosed.
    Type: Application
    Filed: April 29, 2015
    Publication date: January 28, 2016
    Inventors: Philippe Louis LEBOULCH, Robert PAWLIUK, Karen WESTERMAN
  • METHODS FOR ENHANCING THE DELIVERY OF GENE-TRANSDUCED CELLS
    Publication number: 20140199279
    Abstract: The present invention provides novel methods for enhancing the delivery of transduced cells to a subject, which include both methods of selecting for transduced cells and methods of enhancing the reconstitution by transduced cells in a transplant recipient. The present invention further provides transfer vectors, including lentiviral vectors, useful in practicing the methods of the present invention. The methods and vectors of the present invention may be used in gene therapy of a variety of diseases and disorders, including but not limited to hematological diseases and disorders.
    Type: Application
    Filed: December 27, 2011
    Publication date: July 17, 2014
    Applicant: Bluebird Bio, Inc.
    Inventors: Julian David Down, Philippe Louis Leboulch