Patents by Inventor Philippe Mackiewicz

Philippe Mackiewicz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenylimidazolidine preparation process
    Patent number: 6107488
    Abstract: A subject of the invention is a preparation process for the products of formula (I): ##STR1## in which R.sub.1 and R.sub.2 represent in particular hydrogen, cyano, halogen or amino,R.sub.3 represents in particular hydrogen or hydroxyl alkyl,R.sub.4 and R.sub.5 represent in particular optionally substituted alkyl,X and y represent oxygen or sulphur, characterized in that a product of formula (A): ##STR2## is prepared in which W represents a halogen atom or a hydantoin derivative,which is subjected to various reactions in order to obtain the products of formula (I), all their isomers and their salts.
    Type: Grant
    Filed: June 10, 1998
    Date of Patent: August 22, 2000
    Assignee: Hoechst Marion Roussel
    Inventors: Raphael Bouchet, Michel Delthil, Daniel Guilmard, Philippe Mackiewicz
  • Intermediates for the preparation of 6.alpha., 9.alpha.-difluoro steroids
    Patent number: 5556965
    Abstract: A compound of the formula ##STR1## wherein R is hydrogen or an ester remainder, X is hydrogen or fluorine and Y combined with the doted lines represents ##STR2## or X is hydrogen and and Y combined with the dotted lines is ##STR3## and R.sub.1 is the remainder of an enol ether or ester.
    Type: Grant
    Filed: May 15, 1995
    Date of Patent: September 17, 1996
    Assignee: Roussel Uclaf
    Inventors: Jean-Yves Godard, Philippe Mackiewicz, Denis Prat, Christian Richard
  • Preparation of 6.alpha., 9.alpha.-difluoro steroids
    Patent number: 5478957
    Abstract: A process for the preparation of 6.alpha.,9.alpha.-difluoro steroids of the formula ##STR1## wherein R is hydrogen or an ester remainder.
    Type: Grant
    Filed: January 26, 1994
    Date of Patent: December 26, 1995
    Assignee: Roussel-UCLAF
    Inventors: Jean-Yves Godard, Philippe Mackiewicz, Denis Prat, Christian Richard
  • Preparation process for 20-keto 21(S) hydroxy steroids compounds and intermediates
    Patent number: 5473087
    Abstract: Mixtures of compounds of ##STR1## or a mixture of the latter and a compound of the formula ##STR2## which are useful intermediates for the preparation 20-keto-21(S)-hydroxy steroids.
    Type: Grant
    Filed: September 16, 1994
    Date of Patent: December 5, 1995
    Assignee: Roussel-Uclaf
    Inventors: Jean Buendia, Jean-Yves Godard, Philippe Mackiewicz, Christian Richard
  • Lambda-1,4-pregnadiene-3,20-diones
    Patent number: 5451690
    Abstract: A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, acyl of an organic carboxylic acid of 1 to 8 carbon atoms, allyloxycarbonyl, alkoxycarbonyl and aralkoxycarbonyl of up to 8 carbon atoms and alkylsulfonyl and arylsulfonyl of up to 8 carbon atoms and their use to prepare substituted 16,17-methylenedioxy-steroids and novel intermediates.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: September 19, 1995
    Assignee: Roussel Uclaf
    Inventors: Luc Devocelle, Philippe Mackiewicz
  • .delta..sup.1,4 -pregnadiene-3,20-diones
    Patent number: 5434258
    Abstract: A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, acyl of an organic carboxylic acid of 1 to 8 carbon atoms, allyloxycarbonyl, alkoxycarbonyl and aralkoxycarbonyl of up to 8 carbon atoms and alkylsulfonyl and arylsulfonyl of up to 8 carbon atoms and their use to prepare substituted 16,17-methylenedioxy-steroids and novel intermediates.
    Type: Grant
    Filed: February 2, 1994
    Date of Patent: July 18, 1995
    Assignee: Roussel Uclaf
    Inventors: Luc Devocelle, Philippe Mackiewicz
  • Preparation process for 20-keto-21(S) hydroxy steroid compounds and intermediates
    Patent number: 5384419
    Abstract: An improved process for the preparation of 20-keto-21(S)-hydroxy steroids of the Formula ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, R.sub.2 is alkyl of 1 to 12 carbon atoms, and R.sub.3 is alkyl of 1 to 4 carbon atoms and novel intermediates therefrom.
    Type: Grant
    Filed: June 2, 1993
    Date of Patent: January 24, 1995
    Assignee: Roussel-Uclaf
    Inventors: Jean Buendia, Jean-Yves Godard, Philippe Mackiewicz, Christian Richard
  • Process for preparing .DELTA..sup.1,4 -pregnadiene-3,20-diones
    Patent number: 5310896
    Abstract: A compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, acyl of an organic carboxylic acid of 1 to 8 carbon atoms, allyloxycarbonyl, alkoxycarbonyl and aralkoxycarbonyl of up to 8 carbon atoms and alkylsulfonyl and arylsulfonyl of up to 8 carbon atoms and their use to prepare substituted 16,17-methylenedioxysteroids and novel intermediates.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: May 10, 1994
    Assignee: Roussel UCLAF
    Inventors: Luc Devocelle, Philippe Mackiewicz
  • 4,5-bis(aryl) 4H-1,2,4-triazoles derivatives and analgesic use
    Patent number: 5278180
    Abstract: A novel process for the preparation of 4H-1,2,4-triazoles in their racemic or optically active forms of the formula ##STR1## wherein the compounds have analgesic activity.
    Type: Grant
    Filed: May 4, 1992
    Date of Patent: January 11, 1994
    Assignee: Roussel Uclaf
    Inventors: Francois Clemence, Claudine Maushart, Philippe Mackiewicz, Francoise Delevallee