Patents by Inventor Philippe Mangeot

Philippe Mangeot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10968253
    Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
    Type: Grant
    Filed: October 20, 2016
    Date of Patent: April 6, 2021
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE NORMALE SUPERIEURE DE LYON, UNIVERSITE CLAUDE BERNARD LYON 1
    Inventors: Théophile Ohlmann, Philippe Mangeot, Emiliano Ricci
  • Publication number: 20190055288
    Abstract: The present invention relates to a virus-derived particle comprising one or more Cas protein(s), as well as to kits and methods using the same for altering a target nucleic acid.
    Type: Application
    Filed: October 20, 2016
    Publication date: February 21, 2019
    Inventors: Théophile OHLMANN, Philippe MANGEOT, Emiliano RICCI
  • Patent number: 9695446
    Abstract: The present invention relates to direct protein delivery with engineered micro vesicles.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: July 4, 2017
    Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Philippe Mangeot, Vincent Lotteau
  • Publication number: 20140356943
    Abstract: The present invention relates to a non-genetic, detergent-free, bacteria-free method for reprogramming a eukaryotic cell, in particular for obtaining induced pluripotent stem cells (iPS), by using engineered microvesicles carrying at least one reprogramming transcription factor, wherein said engineered microvesicles are virus-free.
    Type: Application
    Filed: February 25, 2014
    Publication date: December 4, 2014
    Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Philippe Mangeot, Vincent Lotteau, Marc Peschanski, Mathilde Girard
  • Publication number: 20140242107
    Abstract: The present invention relates to direct protein delivery with engineered micro vesicles.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Philippe Mangeot, Vincent Lotteau
  • Patent number: 8716020
    Abstract: The present invention relates to a non-genetic, detergent-free, bacteria-free method for reprogramming a eukaryotic cell, in particular for obtaining induced pluripotent stem cells (iPS), by using engineered microvesicles carrying at least one reprogramming transcription factor, wherein said engineered microvesicles are virus-free.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: May 6, 2014
    Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Philippe Mangeot, Vincent Lotteau, Marc Peschanski, Mathilde Girard
  • Patent number: 8697439
    Abstract: The present invention relates to direct protein delivery with engineered micro vesicles.
    Type: Grant
    Filed: November 10, 2010
    Date of Patent: April 15, 2014
    Assignee: INSERM (Institut National de la Sante et de la Recherche Medicale)
    Inventors: Philippe Mangeot, Vincent Lotteau
  • Patent number: 8623278
    Abstract: A continuous automated extraction system and method for physically extracting at least one liquid phase of a series of liquid microsamples which are taken beforehand in discrete packets, both in space and in time, and are in stored is provided. The method may include an extraction system having a centrifuge provided with a plurality of microholders, at least one of which is filled with the corresponding microsample and includes a filling upper portion that is extended by a separating lower portion of smaller cross section than that of the upper portion. Each filled microholder has a mass which is more than ten times the mass of this microsample, in such a way that it is possible to extract, by centrifugation, at a given instant, only a single microsample contained in a single microholder, or several microsamples contained in some or all of these microholders, progressively as the latter are filled.
    Type: Grant
    Filed: October 11, 2012
    Date of Patent: January 7, 2014
    Assignee: Commissariat a l'Energie Atomique et aux Energies Alternatives
    Inventors: Jean-Marc Reymond, Sophie Kerhoas-Cavata, Philippe Mangeot
  • Publication number: 20130034900
    Abstract: The present invention relates to a non-genetic, detergent-free, bacteria-free method for reprogramming a eukaryotic cell, in particular for obtaining induced pluripotent stem cells (iPS), by using engineered microvesicles carrying at least one reprogramming transcription factor, wherein said engineered microvesicles are virus-free.
    Type: Application
    Filed: November 10, 2010
    Publication date: February 7, 2013
    Applicant: INSERM (Institut National de la Sante et de la Recherche Midicale)
    Inventors: Philippe Mangeot, Vincent Lotteau, Marc Peschanski, Mathilde Girard
  • Publication number: 20120322147
    Abstract: The present invention relates to direct protein delivery with engineered micro vesicles.
    Type: Application
    Filed: November 10, 2010
    Publication date: December 20, 2012
    Applicant: INSERM(institut National de la Sante et de la Recherche Medicale)
    Inventors: Philippe Mangeot, Vincent Lotteau
  • Patent number: 8092445
    Abstract: The invention relates to a fluid connection device and to a continuous automated system and method for taking fluid microsamples using this device. A device (20) according to the invention, which is intended to be connected to a first line (21) via a first opening and includes a second opening through which a second line (28) passes, comprises: a female fluid connector (22) that defines the first opening and has an internal fitting surface (23) terminating in a female end (24) into which this first line opens; and a male fluid connector (25) that defines the second opening, which is fitted into the female connector via its external surface (26) and terminates via its male radial end (27) inside the female connector.
    Type: Grant
    Filed: December 12, 2007
    Date of Patent: January 10, 2012
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Jean-Marc Reymond, Sophie Kerhoas-Cavata, Philippe Mangeot, Raphael Boisgard
  • Patent number: 7821248
    Abstract: The invention relates to a device and a method for counting elementary particles emitted by a fluid, the device comprising a line for transferring the fluid and, outside the line, detection means (6a) for detecting the particles that are attenuated by a wall of the line and/or by this fluid. A counting device according to the invention includes at least one counting portion (4a) of oblong cross section which joins together two adjacent portions of the line having a larger flow section and which has an [internal height (h)/internal width (l)] ratio of 20% or less, in which the internal height and the internal width represent the smallest and largest transverse dimensions respectively of the portion, these being measured along two approximately perpendicular directions, said detection means extending transversely to this portion, facing its entire internal width and on either side thereof.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: October 26, 2010
    Assignee: Commissariat A l'Energie Atomique
    Inventors: Jean-Marc Reymond, Sophie Kerhoas-Cavata, Philippe Mangeot
  • Publication number: 20080319344
    Abstract: The invention relates to a fluid connection device and to a continuous automated system and method for taking fluid microsamples using this device. A device (20) according to the invention, which is intended to be connected to a first line (21) via a first opening and includes a second opening through which a second line (28) passes, comprises: a female fluid connector (22) that defines the first opening and has an internal fitting surface (23) terminating in a female end (24) into which this first line opens; and a male fluid connector (25) that defines the second opening, which is fitted into the female connector via its external surface (26) and terminates via its male radial end (27) inside the female connector.
    Type: Application
    Filed: December 12, 2007
    Publication date: December 25, 2008
    Inventors: Jean-Marc Reymond, Sophie Kerhoas-Cavata, Philippe Mangeot, Raphael Boisgard
  • Publication number: 20080315860
    Abstract: The invention relates to a device and a method for counting elementary particles emitted by a fluid, the device comprising a line for transferring the fluid and, outside the line, detection means (6a) for detecting the particles that are attenuated by a wall of the line and/or by this fluid. A counting device according to the invention includes at least one counting portion (4a) of oblong cross section which joins together two adjacent portions of the line having a larger flow section and which has an [internal height (h)/internal width (l)] ratio of 20% or less, in which the internal height and the internal width represent the smallest and largest transverse dimensions respectively of the portion, these being measured along two approximately perpendicular directions, said detection means extending transversely to this portion, facing its entire internal width and on either side thereof.
    Type: Application
    Filed: December 21, 2007
    Publication date: December 25, 2008
    Inventors: Jean-Marc Reymond, Sophie Kerhoas-Cavata, Philippe Mangeot
  • Publication number: 20080317630
    Abstract: The present invention relates in particular to a continuous automated extraction system and method for physically extracting at least one liquid phase of a series of liquid microsamples which are taken beforehand in discrete packets, both in space and in time, and are in stored. An extraction system (10) according to the invention comprises a centrifuge (13) provided with a plurality of microholders (12), at least one of which is filled with the corresponding microsample and includes a filling upper portion that is extended by a separating lower portion of smaller cross section than that of the upper portion. According to the invention, the or each holder thus filled has a mass which is more than ten times the mass of this microsample, in such a way that it is possible to extract, by centrifugation, at a given instant, only a single microsample contained in a single microholder, or several microsamples contained in some or all of these microholders, progressively as the latter are filled.
    Type: Application
    Filed: December 21, 2007
    Publication date: December 25, 2008
    Inventors: Jean-Marc Reymond, Sophie Kerhoas-Cavata, Philippe Mangeot
  • Patent number: 4280075
    Abstract: A device for detecting and locating radiations, comprising at least one cathode brought to a first potential with respect to a reference potential in a sealed enclosure, a plurality of threadlike anodes insulated from one another and photosensitive means, said enclosure being provided with a port-hole transparent to the radiations involved, situated in register with said cathode and anodes, said device further comprising an insulating support with two faces, a portion of one of said two faces, situated in register with said port-hole, being coated with a layer of a conductive material forming a mesh network constituting said cathode, the extremities of said anodes being in the shape of a point and the axes of said anodes respectively coinciding with the axes of the meshes of said network, these points being recessed with respect to the insulating support face, coated with the network conductive meshes.
    Type: Grant
    Filed: July 6, 1979
    Date of Patent: July 21, 1981
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Georges Comby, Philippe Mangeot