Patents by Inventor Philippe Manoury

Philippe Manoury has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4680296
    Abstract: Piperidine derivatives which are compounds of formula (I) ##STR1## wherein Ar.sub.1 and Ar.sub.2 independently represent a phenyl group optionally substituted by a halogen atom, a thienyl group or a pyridinyl group, A represents an alkylene group of 2 to 6 carbon atoms, X represents a CO group or a bond, R.sub.1 represents a hydrogen atom or an alkyl group of 1 to 4 carbon atoms, either R.sub.2 represents a hydrogen atom and R.sub.3 represents a hydrogen atom or a hydroxy group, or R.sub.2 and R.sub.3 together represent a bond, and R.sub.4 represents a hydrogen or halogen atom, or pharmaceutically acceptable acid addition salts thereof are useful as antiallergics and antipruritics.
    Type: Grant
    Filed: October 15, 1985
    Date of Patent: July 14, 1987
    Assignee: Synthelabo
    Inventors: Philippe Manoury, Jean Binet, Elisabeth Dewitte
  • Patent number: 4481207
    Abstract: Compounds of the formula: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 each represent a hydrogen atom, a halogen atom, a (C.sub.1-4)alkoxy radical, a (C.sub.1-4)alkylthio radical, a halogeno(C.sub.1-4)alkyl radical, a (C.sub.1-4)alkyl radical or a cycloalkyl-alkoxy-alkoxy radical or two of the adjacent R symbols together form a methylenedioxy or ethylenedioxy radical, R.sub.6 represents a hydrogen atom, a (C.sub.1-4)alkyl radical, a (C.sub.3-6)cycloalkyl radical or a (C.sub.3-6)cycloalkyl-(C.sub.1-4)alkyl radical, and R.sub.7, R.sub.8 and R.sub.9 each represent a hydrogen atom or a methoxy radical, are new compounds possessing pharmacological properties; they are useful as calcium antagonists and as antihypertensives.
    Type: Grant
    Filed: August 15, 1983
    Date of Patent: November 6, 1984
    Assignee: Synthelabo
    Inventors: Philippe Manoury, Jean Binet, Gerard DeFosse
  • Patent number: 4442126
    Abstract: New compounds of the formula: ##STR1## wherein R.sub.1 represents a hydrogen atom or an alkanoyl group containing from 1 to 4 carbon atoms, R.sub.2 and R.sub.3 each represent a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, and R.sub.4 represents a hydroxy or methoxy group in the 6-position or 7-position, have been found to be useful in therapy, and more particularly in the treatment of cardiovascular diseases and Parkinson's disease.
    Type: Grant
    Filed: September 15, 1982
    Date of Patent: April 10, 1984
    Assignee: Synthelabo
    Inventors: Nigel R. A. Beeley, Gerard Cremer, Michael J. Dimsdale, Philippe Manoury
  • Patent number: 4406907
    Abstract: Pyridine derivatives of the formula: ##STR1## wherein R represents a group R.sub.1 O(CH.sub.2).sub.2 --, in which R.sub.1 is a (C.sub.3-6)cycloalkyl radical, a (C.sub.3-6)cycloalkyl-(C.sub.1-4)alkyl radical or allyl, and R' represents isopropyl or tert.-butyl, are new compounds useful in therapy in the treatment of cardiovascular maladies.
    Type: Grant
    Filed: March 24, 1982
    Date of Patent: September 27, 1983
    Assignee: Synthelabo
    Inventors: Philippe Manoury, Jean Binet, Icilio Cavero
  • Patent number: 4267328
    Abstract: Phenylpiperazine derivatives having the general formula (I) ##STR1## in which R.sub.1 represents a radical S(O).sub.m R.sub.3, S(O).sub.n CF.sub.3 or ##STR2## in which radicals m is 0, 1 or 2, n is 1 or 2, R.sub.3 is an alkyl radical having 1 to 10 carbon atoms and R.sub.4 and R.sub.5 independently represent a hydrogen atom or an alkyl radical having 1 to 4 carbon atoms, or the N atom, R.sub.4 and R.sub.5 together form a heterocyclic ring, which can contain another hetero-atom, and R.sub.2 represents a hydrogen atom, the radical CH.sub.2 --CH.sub.2 --OH or a radical of formula CH.sub.2 --CH.sub.2 --O--COR.sub.6, CH.sub.2 --CH.sub.2 --O--CONHR.sub.6 or CH.sub.2 --CH.sub.2 --O--R.sub.6 in which radicals R.sub.6 being an alkyl radical having 1 to 6 carbon atoms and their pharmaceutically acceptable acid addition salts are useful psychotropic agents and analgesics. Compounds in which R.sub.1 is --SCH.sub.3 and simultaneously R.sub.2 is H are not part of the invention.
    Type: Grant
    Filed: July 27, 1979
    Date of Patent: May 12, 1981
    Assignee: Synthelabo
    Inventors: Henry Najer, Philippe Manoury
  • Patent number: 4242343
    Abstract: Phenylpiperazine derivatives corresponding to the formula (I) ##STR1## in which n is 1, 2 or 3 and R represents the tetrahydrofuryl-2 radical, or the radical CH.sub.2 -SH, or a radical CH.sub.2 -S-alkyl, or a radical CH.sub.2 -O-alkyl or a radical CH.sub.2 -S-CO-alkyl, the alkyls having from 1 to 8 carbon atoms,and also their addition salts with pharmaceutically acceptable acids.These compounds are tranquilizers with psychotropic properties which permit their use in anxiety and depression.
    Type: Grant
    Filed: June 15, 1979
    Date of Patent: December 30, 1980
    Assignee: Synthelabo
    Inventors: Henry Najer, Philippe Manoury