Patents by Inventor Philippe Marlière

Philippe Marlière has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mutant strains capable of producing chemically diversified proteins by incorporation of non-conventional amino acids
    Publication number: 20040014942
    Abstract: The invention concerns mutant prokaryotic cells, in particular E. coli, capable of producing proteins whereof the amino acid sequences comprise at least a non-conventional amino acid, methods for producing and purifying said proteins and the proteins obtained by said methods. The invention also concerns uses of said cells and proteins in different fields such as in therapy, cosmetics, diagnosis or biosynthesis or biodegradation of organic compounds.
    Type: Application
    Filed: June 10, 2003
    Publication date: January 22, 2004
    Inventors: Philippe Marliere, Volker Doring, Henning Mootz
  • Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases
    Publication number: 20030148422
    Abstract: The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function of one of its aminoacyl tRNA synthetases. The present invention is also directed to nucleic acid sequences encoding such mutated aminoacyl tRNA synthetases having their editing site mutated and capable of mischarging its cognate tRNA with a noncanonical amino acid. Also described herein is an improved method for obtaining transformed cells capable of synthetizing in vivo proteins comprising at least a noncanonical amino acid and their use for the production of such proteins.
    Type: Application
    Filed: April 19, 2002
    Publication date: August 7, 2003
    Inventors: Volker Doring, Leslie A. Nangle, Tamara L. Hendrickson, Valerie de Crecy-Lagard, Paul Schimmel, Philippe Marliere
  • Descendants of bacteria devoid of N terminal formylation useful for the production of proteins and peptides
    Publication number: 20030143680
    Abstract: The present invention relates to producing non-formylated proteins and/or peptides in bacterial cells lacking deformylase and/or transformylase.
    Type: Application
    Filed: July 8, 2002
    Publication date: July 31, 2003
    Inventors: Philippe Marliere, Rupert Mutzel, Didier Mazel
  • Oligonucleotide probes and methods for detecting by hybridization the nucleic acids of bacteria and other living organisms
    Patent number: 5407797
    Abstract: The invention relates to a hybridization probe for detecting the existence of bacteria in a sample. It consists of one of the two pentadecadeoxyribonucleotides of sequence(5')d - AAG GAG GTG ATC CAG (3'),(5')d - CTG GAT CAC CTC CTT (3').
    Type: Grant
    Filed: January 11, 1993
    Date of Patent: April 18, 1995
    Assignees: Institut Pasteur, Institut National de la Sante et de la Recherche Medicale
    Inventors: Philippe Marliere, Patrick Grimont