Abstract: The tetrapeptide has the general Formula X-LLAN-Z wherein at the N-terminal end X is selected from H, —CO—R1, —SO2—R1 or a biotinoyl group, at the C-terminal end Z is selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 are selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. A preferred peptide is the Pal-LLAN. This tetrapeptide can stimulate the synthesis of molecules constituting the dermal extracellular matrix, in particular collagen 1 and fibrilin 1, and can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the skin mechanical properties, firmness/tone/elasticity/flexibility, to increase skin density and volume, for a restructuring effect and/or to fight against stretch marks, and skin sagging. The peptide is also adapted to stimulate hair growth.

Abstract: They have the general Formula X-(Xaa)nPG(Xaa)m-Z wherein Xaa is either A or V, either n=2 and m=0, or n=1 and m=1, at the N-terminal end X being selected from H, —CO—R1, —SO2—R1 or a biotinyl group, at the C-terminal end Z being selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 being selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. Preferred peptide sequences are X-AVPG-Z and X-VPGA-Z. These tetrapeptides stimulate the synthesis of molecules constituting the dermal extracellular matrix, in particular collagen 1 and 4 and fibronectin, and can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the skin mechanical properties, firmness/tone/elasticity/flexibility, to increase skin density and volume, for a restructuring effect and/or to fight against stretch marks, and skin sagging.

Abstract: They have the general Formula X-(Xaa)nLE(Xaa)m-Z wherein Xaa is selected from L, K, E and D, either n=2 and m=0, or n=1 and m=1, at the N-terminal end X being selected from H, —CO—R1, —SO2-R1 or a biotinoyl group, at the C-terminal end Z being selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 being selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. Preferred peptide sequences are X-LKLE-Z and X-ELED-Z. These tetrapeptides stimulate the synthesis of molecules constituting the ECM, in particular collagen 1 and 4, hyaluronic acid and fibronectin, and can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the skin mechanical properties, to increase skin density and volume, hydration, and/or to fight against stretch marks, and skin sagging.

Abstract: Disclosed is a polypeptide including a mutated Fc region and having functional activity, mediated by the Fc region, that is modified compared with that of a parent polypeptide. The Fc region includes at least one combination of 2 mutations, the combination being selected from among one mutation selected from among a first set of mutations, and at least one mutation selected from among a second set of mutations, and provided that mutation (i) does not take place on the same amino acid as mutation (ii). Also disclosed are use of the polypeptide, compositions including the same, and methods for preparing the polypeptide.

Abstract: The treatment according to the invention provides for the use of at least one peptide of general Formula X-(Xaa)nK*TSK*X?aa-(Xaa)mZ for a non-therapeutic cosmetic treatment of keratin materials of the skin and of its integuments, including treatment of the epidermis, scalp, hair, and nails, where X, Xaa, K*, X?aa, Z, m and n are as defined. A preferred peptide is Pal-KTSKS.

Abstract: The invention provides the use of at least one alkyl-phthalide or a plant extract comprising mainly said alkyl-phthalide for the topical cosmetic treatment of the skin and of the scalp, in particular an anti-dandruff treatment. According to the invention, a CO2 supercritical extract of Apium graveolens seeds consisting mainly of sedanenolide may be used.

Abstract: Disclosed is to a polypeptide including a mutated Fc region and having functional activity, mediated by the Fc region, that is modified compared with that of a parent polypeptide. The Fc region includes at least one combination of 2 mutations, the combination being selected from among one mutation selected from among a first set of mutations, and at least one mutation selected from among a second set of mutations, and provided that mutation (i) does not take place on the same amino acid as mutation (ii). Also disclosed are use of the polypeptide, compositions including the same, and methods for preparing the polypeptide.

Abstract: The composition comprises a plant extract of the Engelhardtia genus, preferably the species is Engelhardtia chrysolepsis Hance. The treatment according to the invention is a repairing treatment to improve the number of elastic fibres and the quality of its network. Skin elasticity is improved and this helps decrease jowls and eyelids drooping, and the corresponding skin folds. The treatment is particularly adapted to a pre-menopausal or menopausal woman skin.

Abstract: The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid. The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

Abstract: A composition is described, comprising or consisting of chrysin, rosmarinic acid, at least one peptide or derivative thereof, having a sequence of 4 to 10 amino acids comprising the active sequence GQPR and a physiologically acceptable medium. A derivative corresponds to said peptide modified at the N-terminal end with an acyl (—CO—R1), sulfonyl (—SO2—R1) group or a biotinoyl group and/or at the C-terminal end with an OR1, NH2, NHR1 group or NR1R2, R1 and R2 being as defined herein and where the composition acts on the effects of light radiation on the skin and/or of its appendages, and more particularly the effects of blue light to fight against harmful effects and in a particularly advantageous manner at the same time to increase the beneficial effects by resynchronizing the circadian cycle.

Abstract: A peptide having the general Formula (1) X-(Xaa)nK*TFK*-(Xaa)m-Z??(1) is described, where the peptide helps preserve or improve the condition of the epidermis and wherein X, (Xaa)n, (Xaa)m, n, m, K* and Z are as defined.

Abstract: The treatment according to the invention provides the use of at least one peptide having the general Formula X-(Xaa)nK*TTK*X?aa-(Xaa)m-Z for a non-therapeutic cosmetic treatment of keratinous tissues of the skin and of its appendages, where X, Xaa, n, K*, X?aa, m and Z are as defined. A preferred peptide is the Pal-KTTKS.

Abstract: Provided is at least one peptide of formula (I) and its use, where formula (I) is as follows: X-(Xaa1)n-Pro*-(Xaa2)m-Y (I). In formula (I), n=0 and m=1. At the N terminal end of the peptide, X is selected from H, —CO—R1 and —SO2—R1. At the C terminal end of the peptide, Y is selected from OH, OR1, NH2, NHR1 or NR1R2, R1 and R2 being independently selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy and aryloxy group, that can be linear, branched, cyclic, poly-cyclic, non-saturated, hydroxylated, carbonylated, phosphorylated and/or sulphured, with the possibility to have in said group skeleton a O, S and/or N heteroatom. Pro* corresponds to a Proline, an analogue or derivative thereof.

Abstract: The invention provides the use of at least one alkyl-phthalide or a plant extract comprising mainly said alkyl-phthalide for the topical cosmetic treatment of the skin and of the scalp, in particular an anti-dandruff treatment. According to the invention, a CO2 supercritical extract of Apium graveolens seeds consisting mainly of sedanenolide may be used.

Abstract: The invention provides a method for the topical non therapeutical cosmetic treatment of the scalp comprising applying to the scalp an effective amount of at least one alkyl-phthalide or a plant extract comprising mainly said alkyl-phthalide. In particular, the treatment is an anti-dandruff treatment. According to the invention, a CO2 supercritical extract of Apium graveolens seeds consisting mainly of sedanenolide may be used.

Abstract: A specific binding molecule is provided which binds to galectin-3 protein, methods of their production and methods of use.

Abstract: Disclosed is a variant of a parent polypeptide including an Fc fragment, the variant having an increased affinity for the FcRn receptor, and an increased affinity for at least one receptor of the Fc fragment (FcR) chosen from the Fc?RI (CD64), Fc?RIIIa (CD16a) and Fc?RIIa (CD32a) receptors, relative to that of the parent polypeptide, characterised in that it includes: (i) the four mutations 334N, 352S, 378V and 397M; and (ii) at least one mutation chosen from 434Y, 434S, 226G, P228L, P228R, 230S, 230T, 230L, 241L, 264E, 307P, 315D, 330V, 362R, 389T and 389K; the numbering being that of the EU index or the Kabat equivalent.

Abstract: The peptide has from 3 to 10 amino acids comprising at least the sequence K*(Ac)GH or K*(Ac)HG and may further comprise an N-terminus modification, preferably an acylation, and/or a C-terminus modification; K* is selected from the group consisting of lysine, ornithine, diaminobutyric acid, diaminopropionic acid and a hydroxylated derivative thereof; K*(Ac) corresponds to a lysine, ornithine, diaminobutyric acid, diaminopropionic acid or a hydroxylated derivative thereof, acetylated on the amine of their lateral hydrocarbon chain. The two preferred peptides are Pal-K(Ac)GH and Pal-K(Ac)HG. This peptide can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the mechanical properties of the skin, firmness/tonicity/elasticity/flexibility, to increase the density and volume of the skin, for a restructuring, healing effect, and/or to fight stretch marks.

Abstract: A peptide having the general Formula (1) X-(Xaa)nK*TFK*-(Xaa)m-Z??(1) is described, where the peptide helps preserve or improve the condition of the epidermis and wherein X, (Xaa)n, (Xaa)m, n, m, K* and Z are as defined.

Abstract: A specific binding molecule is provided which binds to galectin-3 protein, methods of their production and methods of use.