Patents by Inventor Philippe Msika

Philippe Msika has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11026441
    Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: June 8, 2021
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Alex Saunois, Caroline Baudouin, Sophie Leclere-Bienfait, Sebastien Garnier, Philippe Msika
  • Patent number: 11026880
    Abstract: The invention relates to a composition comprising an extract of passionflower seeds, and preferentially Passiflora edulis seeds. The composition is advantageously cosmetic, pharmaceutical, dermatological or nutraceutical. The subject matter of the invention is also a process for extracting an extract of passionflower seeds and preferentially Passiflora edulis seeds, and also the extract which can be obtained by means of said process. The invention also relates to such a composition or such an extract for use in the prevention or treatment of disorders or pathological conditions of the skin, of the mucous membranes or of the skin appendages, for use in the prevention or treatment of vascular disorders, for use for combating oxidative stress, or else for use in the prevention or treatment of adipose tissue modifications.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: June 8, 2021
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Philippe Msika, Sophie Leclere-Bienfait, Sebastien Debrock, Stephanie Bredif, Sebastien Garnier
  • Publication number: 20210154112
    Abstract: A composition for prevents or slows the appearance of blemishes associated with inflammation of the skin and/or scalp, or eliminates such, the composition including, per 100% by mass: a) 60.0%-75.0% by mass of an organic solvent chosen from 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol, or a blend of the above compounds b) 0.1%-2.0% by mass of a composition including a mass quantity x1, expressed as mass equivalent of 1-O-(2-caffeyol) maloyl-3,5-O-dicaffeoylquinic acid, greater than or equal to 200 mg/g of a compound of general formula (I): in which Q1-Q5 independently of each other represent the hydroxyl radical or a salt thereof or a radical selected among the caffeoyl, maloyl, caffeoyl maloyl and maloyl caffeoyl radicals. At least one of Q1-Q5 represents neither the —OH radical nor a salt thereof; and c) 20.0%-35.0% by mass water.
    Type: Application
    Filed: April 12, 2019
    Publication date: May 27, 2021
    Inventors: Catherine KERN, Christine GARCIA, Christian GOMBERT, Philippe MSIKA
  • Publication number: 20210106510
    Abstract: Disclosed is a composition including, per 100% of its mass: a) 60.0% to 75.0% by mass of an organic solvent (OS1) chosen from 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol, or a mixture of these compounds; b) 0.1% to 2.0% by mass of a composition (ES) including an amount by mass x1, expressed as mass equivalent of 1-O-(2-caffeoyl)maloyl-3,5-di-O-caffeoylquinic acid, of greater than or equal to 200 mg/g of a compound of general formula (I): in which Q1, Q2, Q3, Q4 and Q5 represent, independently of each other, a hydroxyl radical or a salt thereof or a radical chosen from caffeoyl, maloyl, caffeoyl maloyl and maloyl caffeoyl radicals, it being understood that at least one of these radicals Q1, Q2, Q3, Q4 and Q5 represents neither the —OH radical nor a salt thereof; and c) 20.0% to 35.0% by mass of water. Related treatments are also disclosed.
    Type: Application
    Filed: April 10, 2019
    Publication date: April 15, 2021
    Inventors: Catherine KERN, Christine GARCIA, Christian GOMBERT, Philippe MSIKA
  • Publication number: 20210030650
    Abstract: A composition for reducing conditions related to excess sebum on the skin and/or the scalp includes, for 100% of its weight: a) 60.0-75.0 wt. % of an organic solvent selected from 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol, or a mixture of the 10 compounds; b) 0.1-2.0 wt. % of a composition including a quantity by weight x, expressed as equivalent by weight, of 1-O-(2-caffeoyl)maloyl-3,5-O-dicaffeoyl quinic acid, which is higher than or equal to 200 mg/g of a compound of general formula (I): formula (I), in which Q1,-Q5 are, independently from each other, the hydroxyl radical or one of the salts thereof or a radical selected from the radicals caffeoyl, maloyl, caffeoyl maloyl and maloyl caffeoyl. At least one of Q1-Q5 is neither the radical —OH, nor one of the salts thereof; and c) between 20.0 wt. % and 35.0 wt. % of water.
    Type: Application
    Filed: April 12, 2019
    Publication date: February 4, 2021
    Inventors: Catherine KERN, Christine GARCIA, Christian GOMBERT, Philippe MSIKA
  • Patent number: 10837958
    Abstract: The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: November 17, 2020
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Caroline Baudouin, Philippe Msika
  • Patent number: 10620189
    Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: April 14, 2020
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Philippe Msika, Nadege Lachmann, Joachim Fluhr
  • Publication number: 20200085897
    Abstract: The invention relates to an extract of aerial parts of Maca rich in polyphenols, and also to a composition comprising such an extract and, where appropriate, a suitable excipient. The invention also relates to a process for extracting an extract of aerial parts of Maca rich in polyphenols, and also to the extract that can be obtained by means of said process. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths and/or for use thereof in preventing and/or treating vascular disorders. Finally, the invention relates to a cosmetic care process for the skin, the superficial body growths or the mucous membranes, with a view to improving the condition thereof or the appearance thereof, which comprises the administration of such a composition or of such an extract.
    Type: Application
    Filed: September 24, 2019
    Publication date: March 19, 2020
    Applicant: LABORATOIRES EXPANSCIENCE
    Inventors: Alex SAUNOIS, Caroline BAUDOUIN, Sophie LECLERE-BIENFAIT, Sebastien GARNIER, Philippe MSIKA
  • Publication number: 20200011854
    Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.
    Type: Application
    Filed: September 6, 2019
    Publication date: January 9, 2020
    Applicant: Laboratoires Expanscience
    Inventors: Philippe MSIKA, Nadege LACHMANN, Joachim FLUHR
  • Patent number: 10463593
    Abstract: The present invention relates to the use of a lupin peptide extract to prevent loss of skin firmness or to increase the firmness of skin. Advantageously, the lupin peptide extract can prevent the appearance of cellulite and/or reduce skin cellulite.
    Type: Grant
    Filed: July 3, 2015
    Date of Patent: November 5, 2019
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Caroline Baudouin, Sophie Leclere-Bienfait, Philippe Msika, Stéphanie Bredif
  • Patent number: 10458977
    Abstract: The present invention relates to a method for determining the relief of the skin surface of a subject, and hence the degree of maturation of the said skin surface. Methods for identifying active agents, raw materials and formulation are also provided.
    Type: Grant
    Filed: May 15, 2015
    Date of Patent: October 29, 2019
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Nadege Lachman, Philippe Msika, Joachim Fluhr
  • Patent number: 10444226
    Abstract: A method for determining whether the skin surface of a subject is mature/immature in its organization/function, by taking a skin sample and determining the corneodesmosome distribution within the stratum corneum of the sample by an immunoelectron microscopy method.
    Type: Grant
    Filed: September 3, 2014
    Date of Patent: October 15, 2019
    Assignee: LABORATOIRE EXPANSCIENCE
    Inventors: Philippe Msika, Nadège Lachmann, Caroline Baudouin
  • Patent number: 10444225
    Abstract: The present invention relates to a method for determining the isotropy of the skin surface of a subject, and hence the degree of maturation of the said skin surface, by examining various parameters reflecting the cell organization. Methods for identifying active agents, raw materials and formulation are also provided.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: October 15, 2019
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Philippe Msika, Nadège Lachmann, Joachim Fluhr
  • Patent number: 10196607
    Abstract: A skin model comprises keratinocytes capable of overexpressing filaggrin. A method for evaluating the in vitro activity of a formulation or of at least one active agent on the healing of nipple skin and/or on the reduction of nipple skin inflammation, by bringing said active agent or said formulation into contact with a skin model comprising keratinocytes overexpressing filaggrin and also comprising a lesion, and measuring the level of production of at least one biological marker chosen from lactate dehydrogenase (LDH), TNF?, filaggrin, TGF?1 and ?1 integrin.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: February 5, 2019
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Stephanie Bredif, Caroline Baudouin, Philippe Msika, Marisa Meloni
  • Publication number: 20190008757
    Abstract: The invention relates to a cosmetic or dermatological composition containing a polyphenol-enriched extract of Vitex Negundo, typically a root extract obtained using a PAT plant milking®process. The invention further relates to a composition of this kind for use in the prevention or treatment of disorders and diseases affecting the skin, mucous membranes or skin appendages, for use in the prevention or treatment of vascular disorders and for use in the prevention or treatment of extrinsic or intrinsic skin aging. Lastly, the invention relates to a cosmetic care method for the skin, skin appendages or mucous membranes, with a view to improving the condition or appearance thereof, said method consisting in administering such a composition or such an extract.
    Type: Application
    Filed: January 27, 2017
    Publication date: January 10, 2019
    Applicant: Laboratoires Expanscience
    Inventors: Sophie LECLERE-BIENFAIT, Philippe MSIKA
  • Patent number: 10175230
    Abstract: The invention relates to a method for evaluating the effectiveness of an active ingredient selected from C7 avocado sugars, also called avocado perseose, for preventing or treating a deficiency of the skin barrier, said method comprising the determination of the level of expression and/or activation of at least one biological marker, where said biological marker is selected from epidermal maturation markers, lipid barrier markers, hydric regulation markers and stratum granulosum regulation markers.
    Type: Grant
    Filed: April 22, 2014
    Date of Patent: January 8, 2019
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Philippe Msika, Caroline Baudouin, Stephanie Bredif
  • Publication number: 20180369193
    Abstract: The invention relates to an avocado extract rich in polyphenols, containing at least 10% by weight of polyphenols, expressed in gallic acid equivalent relative to the dry extract obtained, wherein said polyphenols contain procyanidins, cafeic acid and cafeic acid derivatives, typically in a proportion of at least 70% by weight, expressed in gallic acid equivalent relative to the total polyphenol content by weight. The invention also relates to a composition comprising an extract according to the invention as active agent and a suitable excipient. The invention also relates to such a composition or such an extract for use thereof in preventing or treating disorders or pathological conditions of the skin, the mucous membranes or the superficial body growths.
    Type: Application
    Filed: August 30, 2018
    Publication date: December 27, 2018
    Applicant: Laboratoires Expanscience
    Inventors: Alex SAUNOIS, Caroline BAUDOUIN, Sophie LECLERE-BIENFAIT, Sebastien GARNIER, Philippe MSIKA
  • Patent number: 10143648
    Abstract: The present invention relates to the use of a peptide and glycoside extract of Schizandra fruit as a cutaneous neurosensory agent, for improving the response of the cutaneous neurosensory system, in particular for: —improving cutaneous innervation in the basal state, —combatting age-related loss of cutaneous innervation in the basal state, advantageously for preventing loss of the cutaneous sensitivity and/or combatting thinning of the epidermis, and/or —improving cutaneous perception of the environment, more particularly for combatting burns, extreme cold and/or pain.
    Type: Grant
    Filed: November 26, 2015
    Date of Patent: December 4, 2018
    Assignee: LABORATOIRES EXPANSCIENCE
    Inventors: Philippe Msika, Caroline Baudouin, Stéphanie Bredif
  • Patent number: 10092495
    Abstract: The invention concerns a use of C7 sugars and derivatives of formula (I), called avocado perseose, which have, inter alia, a protective activity to epidermal skin cells. These C7 sugars and derivatives are capable of maintaining the expression of markers of adult stem cells, in particular basal stem cells. Avocado perseose can also be used for preventing the deleterious effects of environmental damage. Avocado perseose has a beneficial effect on the conservation of the potential of epidermal stem cells and thus helps maintain skin homeostasis.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: October 9, 2018
    Assignee: LABORATOIRE EXPANSCIENCE
    Inventors: Philippe Msika, Caroline Baudouin
  • Publication number: 20180149640
    Abstract: The invention relates to biomarkers of the skin of children and, in particular, that of infants, having altered expression in the presence of urine. Such markers are particularly advantageous as they allow the skin's response to urine to be monitored. The inventors have developed methods for evaluating the efficacy in vitro of formulations in preventing the harmful effects of urine on a child's skin, using a skin model specifically capable of reproducing the characteristics of children's skin.
    Type: Application
    Filed: March 31, 2015
    Publication date: May 31, 2018
    Applicant: Laboratoire Expanscience
    Inventors: Caroline BAUDOUIN, Philippe MSIKA