Patents by Inventor Philippe Nerin
Philippe Nerin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200041513Abstract: The invention relates to a method for detecting, by means of flow cytometry, the presence of normal plasma cells and tumoral plasma cells in a sample of cells from a patient.Type: ApplicationFiled: May 22, 2017Publication date: February 6, 2020Inventors: Guilhem REQUIRAND, Bernard KLEIN, Thierry REME, Jérôme MOREAUX, Sébastien RAIMBAULT, Philippe NERIN, Rosalie PLANTEFEVE, Elina ALATERRE, Jean-Michel GARCIA
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Patent number: 10107801Abstract: The present invention relates to a flow assay method in a liquid medium for an object (or element) of interest via the formation of aggregates of particles that are surface-functionalized by at least one functionalizing molecule, or receptor, specific for said object of interest.Type: GrantFiled: March 11, 2014Date of Patent: October 23, 2018Assignees: HORIBA ABX SASInventors: Aurelien Daynes, Gilles Cauet, Jean-Philippe Gineys, Philippe Nerin, Jerome Bibette
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Patent number: 10073086Abstract: The present invention concerns a device for analyzing biological parameters from a sample (6) comprising (i) first transferring means (5, 20, 25), (ii) first preparing means (7), (iii) means for measuring cellular components (8), (iv) second preparing means (10, 11, 22, 23, 24) capable of carrying out, on a sample from the first preparing means (7), at least one dilution with an assay reagent (R3) comprising particles functionalized at the surface with at least one ligand specific to at least one analyte of interest, (v) immunodetection measurement means (30, 31) capable of assaying at least one analyte of interest by measuring the aggregation of functionalized particles, said device further comprising (i) second transferring means (4, 21, 22, 26) at least partially separate from the first transferring means (5, 20, 25) and (ii) means for applying a magnetic field (28) capable of causing, by magnetic interaction, an acceleration of the aggregation of said functionalized particles, which comprise magnetic collType: GrantFiled: January 29, 2013Date of Patent: September 11, 2018Assignee: HORIBA ABX SASInventors: Jèrôme Bibette, Philippe Nerin, Jean-Philippe Gineys, Gilles Cauet
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Patent number: 9448175Abstract: The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.Type: GrantFiled: August 19, 2013Date of Patent: September 20, 2016Assignee: HORIBA ABX SASInventors: Alexandra Urankar, Philippe Nerin, Moustapha Hariche, Gilles Cauet
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Publication number: 20160153972Abstract: The present invention relates to a flow assay method in a liquid medium for an object (or element) of interest via the formation of aggregates of particles that are surface-functionalized by at least one functionalizing molecule, or receptor, specific for said object of interest.Type: ApplicationFiled: March 11, 2014Publication date: June 2, 2016Inventors: Aurelien DAYNES, Gilles CAUET, Jean-Philippe GINEYS, Philippe NERIN, Jerome BIBETTE
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Publication number: 20150241352Abstract: The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.Type: ApplicationFiled: August 19, 2013Publication date: August 27, 2015Inventors: Alexandra Urankar, Philippe Nerin, Moustapha Hariche, Gilles Cauet
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Patent number: 8940236Abstract: A device for inspecting a biological fluid, including a channel through which the fluid flows, a first inspection module arranged in a first region of the channel, and a second inspection module arranged in a second region of the channel, the device configured to provide a quantity that is representative of output of the second inspection module. The first inspection module is configured to measure at least one electrical property of the fluid passing through the first region. The second inspection module is configured to measure at least one optical property of the fluid passing through the second region. The inspection device also includes a controller connected to the first inspection module and to the second inspection module and configured to control the second inspection module according to the output of the first inspection module.Type: GrantFiled: January 2, 2012Date of Patent: January 27, 2015Assignees: Horiba ABX SAS, Universite de Limoges, Centre National de la Recherche Scientifique CNRSInventors: Nelly Rongeat, Philippe Nerin, Patrick Brunel
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Publication number: 20140377771Abstract: The present invention concerns a device for analyzing biological parameters from a sample (6) comprising (i) first transferring means (5, 20, 25), (ii) first preparing means (7), (iii) means for measuring cellular components (8), (iv) second preparing means (10, 11, 22, 23, 24) capable of carrying out, on a sample from the first preparing means (7), at least one dilution with an assay reagent (R3) comprising particles functionalized at the surface with at least one ligand specific to at least one analyte of interest, (v) immunodetection measurement means (30, 31) capable of assaying at least one analyte of interest by measuring the aggregation of functionalized particles, said device further comprising (i) second transferring means (4, 21, 22, 26) at least partially separate from the first transferring means (5, 20, 25) and (ii) means for applying a magnetic field (28) capable of causing, by magnetic interaction, an acceleration of the aggregation of said functionalized particles, which comprise magnetic collType: ApplicationFiled: January 29, 2013Publication date: December 25, 2014Inventors: Jérôme Bibette, Philippe Nerin, Jean-Philippe Gineys, Gilles Cauet
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Patent number: 8599378Abstract: The invention relates to a method of classifying and flow measuring the refringence of at least two populations of particles present in a fluid. The method uses a light source that has small coherence time, with a coherence length Lc<100 ?m, that is used under extinction conditions at a center wavelength selected as a function of a range of volumes and of a range of refractive indices expected for the particles under consideration. The method uses a device that, together with the light source, forms a converging illuminating beam of aperture angle that is selected as a function of the range of volumes and the range of refractive indices expected for the particles under consideration at the selected center wavelength.Type: GrantFiled: February 2, 2011Date of Patent: December 3, 2013Assignee: Horiba ABX SASInventors: Benoit Merchez, Sebastien Raimbault, Philippe Nerin, Alexandra Urankar
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Publication number: 20130316440Abstract: A device for inspecting a biological fluid, including a channel through which the fluid flows, a first inspection module arranged in a first region of the channel, and a second inspection module arranged in a second region of the channel, the device configured to provide a quantity that is representative of output of the second inspection module. The first inspection module is configured to measure at least one electrical property of the fluid passing through the first region. The second inspection module is configured to measure at least one optical property of the fluid passing through the second region. The inspection device also includes a controller connected to the first inspection module and to the second inspection module and configured to control the second inspection module according to the output of the first inspection module.Type: ApplicationFiled: January 2, 2012Publication date: November 28, 2013Applicants: HORIA ABX SA, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS, UNIVERSITE DE LIMOGESInventors: Nelly Rongeat, Philippe Nerin, Patrick Brunel
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Patent number: 8575568Abstract: The invention relaters to a device (100) for biological analysis by measurement of photoluminescence in a fluid in a measurement tank (111). This device (100) comprises at least two light sources (121, 131) adapted to emit in different spectral areas respectively appropriate for measurement of absorption and fluorescence, and a sensor device (140) comprising a sensor (141), an optical system (142), and filter means (144), which three elements are mutualized in accordance with the invention to enable absorption and/or fluorescence to be measured. In accordance with the invention the internal gain of the sensor (141) is configurable to enable the fluorescence and absorption measurements to be executed sequentially.Type: GrantFiled: June 25, 2009Date of Patent: November 5, 2013Assignee: Horiba ABX SASInventors: Benoit Merchez, Patrick Brunel, Philippe Nerin
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Publication number: 20120296570Abstract: The invention relates to a method of classifying and flow measuring the refringence of at least two populations of particles present in a fluid. The method uses a light source that has small coherence time, with a coherence length Lc<100 ?m, that is used under extinction conditions at a center wavelength selected as a function of a range of volumes and of a range of refractive indices expected for the particles under consideration. The method uses a device that, together with the light source, forms a converging illuminating beam of aperture angle that is selected as a function of the range of volumes and the range of refractive indices expected for the particles under consideration at the selected center wavelength.Type: ApplicationFiled: February 2, 2011Publication date: November 22, 2012Inventors: Benoit Merchez, Sebastien Raimbault, Philippe Nerin, Alexandra Urankar
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Publication number: 20110089340Abstract: The invention relaters to a device (100) for biological analysis by measurement of photoluminescence in a fluid in a measurement tank (111). This device (100) comprises at least two light sources (121, 131) adapted to emit in different spectral areas respectively appropriate for measurement of absorption and fluorescence, and a sensor device (140) comprising a sensor (141), an optical system (142), and filter means (144), which three elements are mutualized in accordance with the invention to enable absorption and/or fluorescence to be measured. In accordance with the invention the internal gain of the sensor (141) is configurable to enable the fluorescence and absorption measurements to be executed sequentially.Type: ApplicationFiled: June 25, 2009Publication date: April 21, 2011Applicant: HORIBA ABX SASInventors: Benoit Merchez, Patrick Brunel, Philippe Nerin
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Patent number: 7777869Abstract: The invention concerns a device (DA) for analyzing microscopic elements, comprising firstly a measuring space (CM) for microscopic elements to be analyzed, secondly at least one source (S) delivering conjugated rays at the measuring space (CM), having at least two different analyzing wavelengths and designed to interact with the microscopic elements in the measuring space (CM) to form interacting rays, thirdly coding means (M) for encoding the rays upstream of the measuring space (CM) with different codes, fourthly optical filtering means (FO) for selectively filtering the interacting rays of fluorescence and/or diffusion depending on their wavelength, fifthly detecting means (DE, DF) for transforming into electric signals part at least of the interacting rays from the measuring space (CM), and sixthly analyzing means (MA) including decoding means (DRE, DRF) for decoding the electric signals to enable data representing the analyzed microscopic elements to be determined.Type: GrantFiled: April 14, 2006Date of Patent: August 17, 2010Assignee: Horiba ABX SASInventors: Philippe Nerin, Didier Lefevre
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Patent number: 7768691Abstract: A dedicated polychromatic light generating device including optical pumping devices used to deliver radiation with at least two different excitation wavelengths and a light-guiding device used to deliver polychromatic light at an output when excited by the radiation in a non-linear interaction regime.Type: GrantFiled: March 8, 2005Date of Patent: August 3, 2010Assignees: Horiba ABX SAS, Universite de Limoges, Centre National de la Recherche Scientifique CNRSInventors: Philippe Nerin, Pierre-Alain Champert, Sébastien Fevrier, Philippe Roy, Vincent Couderc, Philippe Leproux, Ludovic Grossard
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Patent number: 7724371Abstract: An optical device for examining a fluid including a measuring space including a compulsory passage for the fluid to be examined, at least one source delivering a selected light to an optical illuminator serving to collect at least part of the light having traversed the compulsory passage and to deliver the selected light to analyze the collected light so as to deliver signals representing data borne by the collected light. The optical illuminator includes a first light guide including one end, opposite the source, and configured to deliver the light, derived from the source, in accordance with a selected geometry to illuminate the compulsory passage in a substantially uniform manner and under a substantially constant intensity.Type: GrantFiled: November 7, 2005Date of Patent: May 25, 2010Assignee: Horiba ABX SASInventors: Philippe Nerin, Paul Moreno, Didier Cremien
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Publication number: 20090161107Abstract: An optical device for examining a fluid including a measuring space including a compulsory passage for the fluid to be examined, at least one source delivering a selected light to an optical illuminator serving to collect at least part of the light having traversed the compulsory passage and to deliver the selected light to analyze the collected light so as to deliver signals representing data borne by the collected light. The optical illuminator includes a first light guide including one end, opposite the source, and configured to deliver the light, derived from the source, in accordance with a selected geometry to illuminate the compulsory passage in a substantially uniform manner and under a substantially constant intensity.Type: ApplicationFiled: November 7, 2005Publication date: June 25, 2009Applicant: HORIBA ABX SAInventors: Philippe Nerin, Paul Moreno, Didier Cremien
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Publication number: 20090059207Abstract: The invention relates to a device and to a method for measuring photoluminescence in a fluid present in a measurement vessel. According to the invention, the fluid in the measurement vessel simultaneously receives at least two excitation beams coming from two optical systems. The optical systems are positioned so that their axes form between them a non-zero obtuse angle other than 180° around the measurement vessel. A measurement of light emission is deduced according to the invention from coupling data obtained from emission beams picked up simultaneously by the pickup elements. The optical systems are also positioned in such a manner that there exists at least one partial overlap beam between the excitation beam from the source of a first optical system and the emission beam picked up by the pickup element of a second optical system.Type: ApplicationFiled: March 2, 2007Publication date: March 5, 2009Inventors: Philippe Nerin, Benoit Merchez, Jean-Philippe Gineys, Didier Lefevre
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Publication number: 20080283754Abstract: The invention concerns a device (DA) for analyzing microscopic elements, comprising firstly a measuring space (CM) for microscopic elements to be analyzed, secondly at least one source (S) delivering conjugated rays at the measuring space (CM), having at least two different analyzing wavelengths and designed to interact with the microscopic elements in the measuring space (CM) to form interacting rays, thirdly coding means (M) for encoding the rays upstream of the measuring space (CM) with different codes, fourthly optical filtering means (FO) for selectively filtering the interacting rays of fluorescence and/or diffusion depending on their wavelength, fifthly detecting means (DE, DF) for transforming into electric signals part at least of the interacting rays from the measuring space (CM), and sixthly analyzing means (MA) including decoding means (DRE, DRF) for decoding the electric signals to enable data representing the analyzed microscopic elements to be determined.Type: ApplicationFiled: April 14, 2006Publication date: November 20, 2008Applicant: HORIBA ABX SASInventors: Philippe Nerin, Didier Lefevre
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Publication number: 20070216989Abstract: A dedicated polychromatic light generating device including optical pumping devices used to deliver radiation with at least two different excitation wavelengths and a light-guiding device used to deliver polychromatic light at an output when excited by the radiation in a non-linear interaction regime.Type: ApplicationFiled: March 8, 2005Publication date: September 20, 2007Applicants: HORIBA ABX SAS, Universite De Limoges, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRSInventors: Philippe Nerin, Pierre-Alain Champert, Sebastien Fevrier, Philippe Roy, Vincent Couderc, Philippe Leproux, Ludovic Grossard