Abstract: The present invention relates to a device (10) for sampling solid particles from a sealed enclosure (12), sampling device (10) comprising a tubular body (18) carrying a sampling head (16), sampling head (16) being configured for gravity sampling of a volume of solid particles (14) from the enclosure, the device comprising a tubular pipe (52) attached to tubular body (18) and forming a non-zero angle with tubular body (18), tubular body (18) comprising a deflector (50) for deflecting solid particles (14) in tubular pipe (52). Additionally, sampling device (10) comprises a capacitive valve for discharge of the solid particles positioned downstream from tubular pipe (52). The invention also relates to a method for sampling solid particles, and a method for revamping a sampling device (10).

Abstract: The present invention relates to a method of profiling the energetic metabolism of a single cells. The inventors designed a method that rapidly and efficiently measures the protein synthesis level in single cells upon inhibition of the different energy producing pathways. The method developed by the inventors permits to acquire energetic metabolism profiles with single cell resolution in non-abundant cells ex-vivo and permits to decrease to a minimum manipulation time, incubations and cost of sample preparation. The method is particularly suitable for determining activation state of a cell, diagnosing inflammatory diseases, or predicting the response of a subject to immunotherapy treatment. In particular, the present invention relates to a method of profiling the energetic metabolism in single cells comprising measuring the protein synthesis level of the cells and contacting the cell with different inhibitors of metabolic pathways.

Abstract: The present invention relates to the general field of treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the treatment of immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.

Abstract: The present invention relates to the use of Guanabenz or derivates thereof for the treatment of type I IFN-dependent pathologies. The inventors investigate here how pharmacological interference with the eIF2?-P pathway can be beneficial for the treatment of immune pathological conditions. Using both mouse and human DCs, as well as B cells, they show that GBZ prevents endosomal toll-like-receptor 9 (TLR9) activation by CpG ODN or DNA-Immunoglobulin complexes, as well as TLR3, TLR7 and RIG-I like receptors (RLR, RIG-I or MDA5), by RNAs or small compounds. In vivo, GBZ treatment protects mice from CpG-dependent cytokine shock and decreases anti-nucleic acid auto-antibodies production in the TMPD-induced systemic lupus erythematosus model. The present invention thus relates to a method of treating a type I IFN-dependent pathology in a subject comprising administering the subject with Guanabenz or a derivative thereof.

Abstract: The present invention relates to the general field of the treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the of treatment an immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.

Abstract: The present invention relates to the general field of treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the treatment of immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.

Abstract: The present invention relates to the general field of the treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the of treatment an immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.

Abstract: A device for the detection of the passage of objects, people or animals bearing a radio frequency identification (RFID) tag, including at least one mobile support which, when at rest, forms a barrier to the passage of the objects, people or animals and which, when in contact with the latter, is capable of moving towards a withdrawn position, this mobile support bearing an antenna connected electrically to an RFID tag reader.

Abstract: The present invention relates to the general field of the treatment and prevention of diseases involving an inflammatory condition, namely sepsis or infectious or viral diseases as well as diseases requiring for the of treatment an immunosuppressive activity namely autoimmune diseases and graft rejection. In particular, the invention relates to an inhibitor of the activity or the formation of the PP1/GADD34 complex for the treatment of a condition requiring an immunosuppressive activity or an anti-inflammatory activity.

Abstract: A device for the detection of the passage of objects, persons or animals bearing a so-called RFID tag, the device including at least one first movable support bearing an antenna electrically connected to a tag reader and at least one second movable support, each of the movable supports forming, when idle, a barrier with respect to the passage of the objects, persons or animals, and which, on contact with these latter, is movable to a retracted position, the second movable support being arranged upstream of the first movable support with respect to the direction of passage of the objects, persons or animals and being made of a material attenuating the passage of the electromagnetic waves in the direction opposite to that of the passage of the objects, persons or animals.

Abstract: A device for the detection of the passage of objects, people or animals bearing a radio frequency identification (RFID) tag, including at least one mobile support which, when at rest, forms a barrier to the passage of the objects, people or animals and which, when in contact with the latter, is capable of moving towards a withdrawn position, this mobile support bearing an antenna connected electrically to an RFID tag reader.