Patents by Inventor Philippe Quillardet

Philippe Quillardet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for detecting the mutagenicity of substances susceptible of inducing the deterioration of cellular DNA, utilizing the production of an SOS response
    Patent number: 4849335
    Abstract: A method for the detection of the mutagen effect of a substance or composition by producing culture of a micro-organism harboring a recombinant of a sfi gene and of a gene coding for a dosable enzyme in the presence of said substance or composition and measuring the activity of the dosable enzyme induced under the control of the sfi gene. When the latter is activated due to the mutagen character of said substance or composition, measuring the activity of a distinct enzyme synthesized by the microorganism and coded by a gene not involved in the activation process of the sfi gene and measuring the variation of the ratio of the activity of the abovesaid dosable enzyme to the activity of said distinct enzyme. Then comparing the variation that of the ratio of the activities of the same enzyme in a culture of the same microorganism, but in the absence of the mutagen substance.
    Type: Grant
    Filed: May 25, 1984
    Date of Patent: July 18, 1989
    Assignee: Institut Pasteur
    Inventors: Maurice Hofnung, Philippe Quillardet, David Perrin, Olivier Huisman, Richard D'Ari