Patents by Inventor Philippe Reb

Philippe Reb has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11845823
    Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
    Type: Grant
    Filed: July 26, 2021
    Date of Patent: December 19, 2023
    Assignee: Biosphere Medical, Inc.
    Inventor: Philippe Reb
  • Patent number: 11229604
    Abstract: Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.
    Type: Grant
    Filed: August 16, 2018
    Date of Patent: January 25, 2022
    Assignee: Biosphere Medical, Inc.
    Inventors: Philippe Reb, Meriadeg Thomas
  • Publication number: 20220016270
    Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
    Type: Application
    Filed: July 26, 2021
    Publication date: January 20, 2022
    Inventor: Philippe Reb
  • Patent number: 11116855
    Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: September 14, 2021
    Assignee: Biosphere Medical, Inc.
    Inventor: Philippe Reb
  • Patent number: 11052164
    Abstract: The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: July 6, 2021
    Assignee: Biosphere Medical, Inc.
    Inventors: Philippe Reb, Celine Chaix
  • Patent number: 10695440
    Abstract: Biomaterials suitable for use as drug eluting, Magnetic Resonance Imaging (“MRI”) detectable implants for vascular occlusion are provided, as are methods of producing such biomaterials. Further, methods of treating an individual suffering from a solid tumor are provided.
    Type: Grant
    Filed: May 23, 2013
    Date of Patent: June 30, 2020
    Assignee: Biosphere Medical, Inc.
    Inventors: Philippe Reb, Celine Chaix, Meriadeg Thomas
  • Publication number: 20200030238
    Abstract: Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.
    Type: Application
    Filed: August 7, 2019
    Publication date: January 30, 2020
    Inventor: Philippe Reb
  • Publication number: 20200023087
    Abstract: The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.
    Type: Application
    Filed: September 26, 2019
    Publication date: January 23, 2020
    Inventors: Philippe Reb, Celine Chaix
  • Patent number: 10434200
    Abstract: The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.
    Type: Grant
    Filed: June 6, 2017
    Date of Patent: October 8, 2019
    Assignee: Biosphere Medical, Inc.
    Inventors: Philippe Reb, Celine Chaix
  • Patent number: 10376469
    Abstract: Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: August 13, 2019
    Assignee: Biosphere Medical, Inc.
    Inventor: Philippe Reb
  • Publication number: 20190231908
    Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
    Type: Application
    Filed: April 11, 2019
    Publication date: August 1, 2019
    Inventor: Philippe Reb
  • Patent number: 10293063
    Abstract: The present invention relates to compositions and methods for treating diseases and disorders including cancer and various other angiogenic-dependent diseases, vascular malfunctions, arteriovenous malformations (AVM), hemorrhagic processes and treatment of pain, in particular tumor-related pain by drug delivery and/or therapeutic embolization using microspheres. More particularly the invention relates to microspheres containing non-ionic contrast agents, to compositions comprising these microspheres, as well as methods for preparing and using such compositions for embolization therapy. The invention further relates to compositions and methods using detectable microspheres for targeted drug delivery, irrespective of whether embolization is also needed.
    Type: Grant
    Filed: May 21, 2015
    Date of Patent: May 21, 2019
    Assignee: Merit Medical Systems, Inc.
    Inventor: Philippe Reb
  • Publication number: 20190133949
    Abstract: Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.
    Type: Application
    Filed: August 16, 2018
    Publication date: May 9, 2019
    Inventors: Philippe Reb, Meriadeg Thomas
  • Patent number: 10265423
    Abstract: Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
    Type: Grant
    Filed: January 11, 2016
    Date of Patent: April 23, 2019
    Assignee: Biosphere Medical, Inc.
    Inventor: Philippe Reb
  • Patent number: 10022469
    Abstract: Provided herein, for example, are microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Also provided are methods of producing microspheres comprising a gelatin or gelatin substitute and a copolymer of a N-tris-hydroxymethyl methylacrylamide monomer unit, a diethylaminoethylacrylamide monomer unit and a N,N-methylene-bis-acrylamide monomer unit. Further provided herein, for example, are compositions comprising the microspheres and methods of using the microspheres and compositions thereof.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: July 17, 2018
    Assignee: Biosphere Medical, SA
    Inventors: Philippe Reb, Marion Pierre, Barbara De Gioannis, James Krom
  • Publication number: 20170333579
    Abstract: The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.
    Type: Application
    Filed: June 6, 2017
    Publication date: November 23, 2017
    Inventors: Philippe Reb, Celine Chaix
  • Patent number: 9744303
    Abstract: Pre-loaded syringes for delivering an embolic agent are disclosed herein. Methods related to syringes pre-loaded with an embolic agent are also disclosed.
    Type: Grant
    Filed: July 9, 2014
    Date of Patent: August 29, 2017
    Assignee: Merit Medical Systems, Inc.
    Inventors: Philippe Reb, Peter C. Sutcliffe
  • Publication number: 20170231915
    Abstract: Microspheres, compositions including the microspheres, and methods of using the microspheres are disclosed herein. The microspheres can be substantially spherical and can include a copolymer of a monomer (such as an acrylic monomer) and a cyclodextrin or a derivative thereof. The microspheres can also include a therapeutic agent, such as a platinum-based drug.
    Type: Application
    Filed: February 17, 2017
    Publication date: August 17, 2017
    Inventor: Philippe Reb
  • Patent number: 9693833
    Abstract: An absorbent cleaning device for use during a surgical procedure is disclosed. The absorbent cleaning device may comprise a substantially non-fibrous or non-particulate absorbent material and at least one opening. The opening may comprise a slit or channel and be configured to accommodate a portion of a medical appliance or an elongate medical device. The absorbent cleaning device may be configured to clean the medical appliance or the elongate medical device. The absorbent cleaning device may also be configured to retain or secure a medical appliance or elongate medical device during a surgical procedure.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: July 4, 2017
    Assignee: Merit Medical Systems, Inc.
    Inventors: Jim Mottola, Franklin J. Miller, Philippe Reb
  • Patent number: 9687573
    Abstract: The present disclosure relates to polymeric materials that may be labeled with a radioisotope, to processes for producing the labeled polymeric material, and to methods of using the materials in analytical and therapeutic applications. Specifically, the disclosure relates to injectable and implantable microparticles, such as microspheres, which are associated with radioisotopes such that the microparticles are both therapeutic and detectable. The radioisotope-containing microparticles are useful for embolization and other therapeutic medical applications.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 27, 2017
    Assignee: Biosphere Medical, Inc.
    Inventors: Philippe Reb, Celine Chaix