Abstract: Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) ?in the presence of a suitable solvent; b) reacting an intermediate of formula (IV) ?with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent; c) dehydrating the corresponding amide of the compound of formula (I).

Abstract: The invention concerns a method of producing at least one mechanical component of a MEMS or NEMS structure from a monocrystalline silicon substrate, comprising the steps of: forming anchoring zones in one face of the substrate to delimit the mechanical component, forming, on the face of the substrate, a lower protective layer made of material other than silicon and obtained by epitaxy from the face of the substrate, forming, on the lower protective layer, a silicon layer obtained by epitaxy from the lower protective layer, forming an upper protective layer on the silicon layer, etching the upper protective layer, the silicon layer and the lower protective layer, according to a pattern defining the mechanical component, until the substrate is reached and to provide access routes to the substrate, forming a protective layer on the walls formed by the etching of the pattern of the mechanical component in the epitaxied silicon layer, releasing the mechanical component by isotropic etching of the substrate from

Abstract: A tire is provided with a force measurement device embedded, for example, in an isolated element such as a tread block. The device may be a stud-type device. The device includes a rigid stem connected to a deformable substantially flat membrane, which includes a detector for detecting a deformation of the membrane. The stem further includes a portion designed to be in contact with an element on which a force can act. The stem also includes an anchor that collaborates with the element. The anchor functions to improve the transmission of a load to the deformable membrane.

Abstract: A device, with piezoresistive detection comprising at least: a proof body on which an effort to be measured is exerted, means of detecting a strain exerted by the proof body under the action of the effort, comprising at least one suspended piezoresistive strain gauge, a strain amplifier cell comprising at least two rigid arms mechanically linked to each other by at least one link element at the level of a first of their ends, a second end of a first of the two rigid arms being mechanically linked to the proof body, a second end of a second of the two rigid arms being fixed to the substrate, the link element being mechanically linked to a first end of the suspended piezoresistive strain gauge.

Abstract: The present patent application concerns compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a mono or bicyclic saturated nitrogen-containing ring; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.

Abstract: A computer-readable storage medium comprising instructions which when executed cause a computing device to receive a request from a client to display a map projection of a spatial reference, wherein the spatial reference comprises a location and a scale, select a projected coordinate system from a plurality of projected coordinate systems based on the spatial reference and a set of business rules, generate the map projection of the spatial reference using the projected coordinate system, and send the map projection to the client, wherein the map projection is displayed on the client.

Abstract: A sensor structure is disclosed, notably for a harsh environment in a motor vehicle. The sensor includes a sensor body having, at one end, an element sensitive to the quantity to be measured in the harsh environment and, at another end, a circuit for connecting it, placed outside the harsh environment, physically separated from each other, connected by means for transmitting data without a connection, and between which means are provided that are permeable to data, for protecting the connecting circuit from the environment.

Abstract: A bistable MEMS microswitch produced on a substrate and capable of electrically connecting ends of at least two conductive tracks, including a beam suspended above the surface of the substrate. The beam is embedded at its two ends and is subjected to compressive stress when it is in the non-deformed position. The beam has an electrical contact configured to produce a lateral connection with the ends of the two conductive tracks when the beam is deformed in a horizontal direction with respect to the surface of the substrate. Actuators enable the beam to be placed in a first deformed position, corresponding to a first stable state, or in a second deformed position, corresponding to a second stable state, and the electrical contact ensures connection of the ends of the two conductive tracks.

Abstract: This invention relates to a resonant device with detection in the piezo-resistive plane made using surface technologies on a bulk, which comprises a resonator connected to this bulk by at least one embedded portion, means of exciting this resonator and detection means comprising at least one suspended beam type strain gauge made from piezo-resistive material, in which each strain gauge has a common plane with the resonator, and is connected to this resonator at a point situated outside of this at least one embedded portion to increase the stress observed by this strain gauge.

Abstract: A comb capacitive accelerometer comprising a substrate, a mobile electrode relative to said substrate fitted with a plurality of mobile fingers, an electrode fixed relative to said substrate fitted with a plurality of fixed fingers, each of said mobile fingers being positioned between two contiguous fixed fingers so as to form a microstructure with interdigital combs. According to the invention the mobile fingers are connected to one another by at least a first connecting beam etched directly into the substrate, and/or the fixed fingers are connected to one another by at least a second connecting beam etched directly in the substrate.

Abstract: A sensor structure notably for a harsh environment in a motor vehicle is disclosed. The sensor structure has a sensor body (1) having at one end an element (2) sensitive to the quantity to be measured in the harsh environment and at another end a connection circuit (3) for the latter, placed away from the harsh environment, and physically separated from one another. The sensor structure is connected by means for transmitting information by carrier current on an electrical conductor (5) of the sensor with which the sensitive element and the connection circuit are associated by wireless coupling means and between which are provided means (4) for protecting the connection circuit from the environment.

Abstract: The invention relates to compounds of the general formula (I): to the process for preparing them, and to the use thereof as a therapeutic agent having the property of being selective ligands for the dopamine D3 receptor. These selective D3 ligands are useful as medicines in neuropsychiatry, in particular in the treatment of psychotic or depressive states, or in the treatment of motor disorders, such as dyskinesia or essential tremor. They are furthermore useful in the treatment of dependency on nicotine, cocaine, alcohol, opioids and for facilitating withdrawal in drug-dependent individuals.

Abstract: The invention concerns compounds of general formula (I), a method for preparing same, as well as their use as therapeutic agent.

Abstract: A force measuring device has a rigid stem joined to an essentially flat deformable membrane. The membrane includes detectors for detecting a deformation of the membrane. A portion of the stem comes in contact with an element capable of being subjected to the action of a force. The stem has slots forming anchoring means for interacting with the element. The force measuring device is for use, in particular, in improving the transmission of loads to the deformable membrane.

Abstract: The present patent application concerns new compounds of formula (I) with R1 and R2 taken together with the nitrogen atom to which they are attached, form a saturated nitrogen-containing ring, A is a saturated C1-4 alkylene and B a C3-4 alkylene or alkenylene chain; their preparation and their use as a H3 receptor ligand for treating e.g. CNS disorders like Alzheimer's disease.

Abstract: This invention relates to a process for preparing 4-[(1,6-dihydro-6-oxo-2-pyrimidinyl)-amino]benzonitrile (I) starting from a 4-oxo-1,6-dihydro-pyrimidinylcarboxylic acid ester (II) or starting from a guanidine derivative which is reacted with an alkoxy-methylene malonic acid ester to an ester (II) which is converted to (I), which reaction sequence may be a one-pot procedure.

Abstract: Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) ?in the presence of a suitable solvent; b) reacting an intermediate of formula (IV) ?with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent; c) dehydrating the corresponding amide of the compound of formula (I).

Abstract: Compounds of the general formula (I) below: are provided along with a process for preparing them, and these compounds may be used as therapeutic agents, e.g., for prevention and/or treatment of a neuropsychiatric illness or any illness involving the dopamine D3 receptor.

Abstract: Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are provided, said processes comprise: a) reacting 4-(2-cyanoethenyl)-2,6-dimethylbenzenamine with an intermediate of formula (III) in the presence of a suitable solvent; b) reacting an intermediate of formula (IV) with acrylonitrile in the presence of a suitable palladium catalyst, a suitable base and a suitable solvent; c) dehydrating the corresponding amide of the compound of formula (I).

Abstract: A tire is provided with a force measurement device embedded, for example, in an isolated element such as a tread block. The device may be a stud-type device. The device includes a rigid stem connected to a deformable substantially flat membrane, which includes a detector for detecting a deformation of the membrane. The stem further includes a portion designed to be in contact with an element on which a force can act. The stem also includes an anchor that collaborates with the element. The anchor functions to improve the transmission of a load to the deformable membrane.