Abstract: The present invention relates to a non invasive diagnostic method of pancreatic ductal adenocarcinoma (PDAC) in a subject said method comprising the step of measuring the level of ?ig-h3 protein in a blood sample wherein the serum level of ?ig-h3 is positively correlated with the risk of having a PDAC. By following studies on 2 distinct cohorts of 20 and 104 of PDAC patients, and on PDAC mouse model, the inventors show that ?ig-h3 can be directly detected in the blood sample and ?ig-h3 is expressed very early in tumorigenesis in pancreatic neoplastic lesions. The present invention also relates to antagonist of ?ig-h3 protein, for use in the treatment of PDAC. The inventors found that ?ig-h3 bind directly on CD8+ T cells by reducing their activation and cytotoxic properties. Furthermore, the use of neutralizing ?ig-h3 antibodies in PDAC mouse model, reduced tumor growth by enhancing CD8+ T cell anti-tumoral response.

Abstract: A seal assembly including a seal element which has at least one seal portion for sealing a vertically movable window pane of a vehicle door against a vertical window frame limb. The seal element additionally has a seal portion for forming a gap which is formed between a center that borders the vehicle door and a vertical window pane edge side facing the center.

Abstract: A sealing element including a cover strip, in particular for sealing a window pane at the inlet of a window channel into which the window pane can be retracted. A portion of the sealing element, which portion is to be produced by injection molding, is connected to the cover strip by being molded onto the cover strip. In a corresponding method, the cover strip is preheated such that its shrinkage is matched to the shrinkage of the molded-on material, until the cover strip has cooled down to approximately the ambient temperature.

Abstract: A seal between a frame part of a vehicle door window and the upper edge of a lowerable window pane of the vehicle door window. A seal profiled element of plastic is provided, which is slid onto a flange protruding upward from the frame part of the vehicle window and/or which is connected to a tube-shaped seal section for forming a seal between the frame part and a border surface of a door opening in a vehicle body.

Abstract: A seal between a frame part of a vehicle door window and the upper edge of a lowerable window pane of the vehicle door window. A seal profiled element of plastic is provided, which is slid onto a flange protruding upward from the frame part of the vehicle window and/or which is connected to a tube-shaped seal section for forming a seal between the frame part and a border surface of a door opening in a vehicle body.

Abstract: A seal assembly including a seal element which has at least one seal portion for sealing a vertically movable window pane of a vehicle door against a vertical window frame limb. The seal element additionally has a seal portion for forming a gap which is formed between a center that borders the vehicle door and a vertical window pane edge side facing the center.

Abstract: A sealing element including a cover strip, in particular for sealing a window pane at the inlet of a window channel into which the window pane can be retracted. A portion of the sealing element, which portion is to be produced by injection molding, is connected to the cover strip by being molded onto the cover strip. In a corresponding method, the cover strip is preheated such that its shrinkage is matched to the shrinkage of the molded-on material, until the cover strip has cooled down to approximately the ambient temperature.