Abstract: The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.

Abstract: A luminophore having the general empirical formula X?1-xA?y(Al1+zA?3-z)O4:E? that crystallizes in a tetragonal crystal system. X? may be Mg, Ca, Sr, Ba, and combinations thereof; A? may be Li, Na, K, Rb, Cs, and combinations thereof; E? may be Eu, Ce, Yb, Mn, and combinations thereof; 0<x<0.25; y?x; andz = 0.5 ( 2 ? x - y ) .

Abstract: The present invention provides selected glutarimides which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: A luminophore having the general empirical formula X?1?xA?y(Al1+zA?3?z)O4:E? that crystallizes in a tetragonal crystal system. X? may be Mg, Ca, Sr, Ba, and combinations thereof; A? may be Li, Na, K, Rb, Cs, and combinations thereof; E? may be Eu, Ce, Yb, Mn, and combinations thereof; 0<x<0.25; y?x; and z=0.5(2x?y).

Abstract: The present invention provides compounds and intermediates. The present invention also provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.

Abstract: The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.

Abstract: According to an aspect of the present invention, there is provided a method for providing additional bandwidth to receivers that can decode a higher modulation comprising trading a peak-to-average power ratio (PAPR) reduction induced constellation noise of all or a subset of in-band on-channel (IBOC) carriers within an orthogonal frequency division multiplexing (ODFM) waveform with data carrying superposition modulation.

Abstract: The present invention provides selected glutarimides which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. The disclosed compounds are useful for the treatment of cancer.

Abstract: According to an aspect of the present invention, there is provided a method for providing additional bandwidth to receivers that can decode a higher modulation comprising trading a peak-to-average power ratio (PAPR) reduction induced constellation noise of all or a subset of in-band on-channel (I BOC) carriers within an orthogonal frequency division multiplexing (ODFM) waveform with data carrying superposition modulation.

Abstract: A system for peak-to-average-power ratio (PAPR) reduction of a frequency shifted plurality of digital broadcast signals taking into account the combined signal peaks in order to transmit the signals more efficiently in a single broadcast transmission system. The PAPR algorithm takes into account a rotating constellation phase offset for the shifted signals corresponding to the amount of applied frequency shift. In the case of a dual sideband In-Band-On-Channel (IBOC) signal typically used in conjunction with an FM carrier in the center, the sidebands can be interleaved to create a new IBOC signal definition and take the place of the FM carrier for an all-digital transmission that is backward compatible with IBOC receivers allowing for a gradual migration to all digital broadcasting.

Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein X, Y, Z, A, L, B, and R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

Abstract: A luminophore may have the general molecular formula NavKxRbyLizCsw (Li3SiO4)4:E, where: v+x+y+z+w = 4; 0 < v < 4; 0 < x < 4; 0 < y < 4; 0 < z < 4; 0 < w < 4; and E = Eu, Ce, Yb, Mn, or combinations thereof.

Abstract: The present invention provides compounds and intermediates. The present invention also provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.

Abstract: The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and their use for the treatment of abnormal cellular proliferation. The present invention also provides compounds that may be used as synthetic intermediates in the synthesis of bifunctional compounds used for targeted protein degradation.

Abstract: A broadcast system may have less restrictive timing constraints by providing synchronous processing chains for the HD audio portion and the FM audio portion so that no samples are added or removed from when the input audio is first sampled at an input rate and when the signals are combined and output by a digital analog converter operating at an output rate. The signals can be buffered within the synchronous processing paths and the state of the buffer can be used to control the input rate of the sampler. Graceful change over across multiple input sources can be achieved provided all input source input rates are controlled to by the overall output rate and all input sources are phase aligned to produce output symbols at the same time.

Abstract: The invention provides bifunctional compounds of formula (I) or a pharmaceutically acceptable salt thereof. Formula (I). The compounds cause the degradation of SMARCA2 via the targeted ubiquination of SMARCA2 protein and subsequent proteasomal degradation and are thus useful for the treatment of cancer. The targeting ligand is of formula (TL).

Abstract: The invention provides a bifunctional compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein said Targeting Ligand, Linker and Degron are as described herein.

Abstract: A luminophore having the general empirical formula X?1?xA?y(Al1+zA?3?z) O4:E? that crystallizes in a tetragonal crystal system. X? may be Mg, Ca, Sr, Ba, and combinations thereof; A? may be Li, Na, K, Rb, Cs, and combinations thereof; E? may be Eu, Ce, Yb, Mn, and combinations thereof; 0<x<0.25; y?x; and z=0.5(2x?y).

Abstract: According to an aspect of the present invention, there is provided a method for providing additional bandwidth to receivers that can decode a higher modulation comprising trading a peak-to-average power ratio (PAPR) reduction induced constellation noise of all or a subset of in-band on-channel (IBOC) carriers within an orthogonal frequency division multiplexing (ODFM) waveform with data carrying superposition modulation.

Abstract: A luminophore may have the general empirical formula X3A4Si3O8N2:E, where: X=Mg, Ca, Sr, Ba, Zn, or combinations thereof; A=Li, Na, K, Rb, Cs, Cu, Ag, or combinations thereof; Z=Al, Ga, B, or combinations thereof; and E=Eu, Ce, Yb, Mn, or combinations thereof.