Patents by Inventor Philippe Verwaerde

Philippe Verwaerde has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[D]IMIDAZOL-2-AMINE SULPHATE SALTS AND SOLVATES THEREOF FOR THE TREATMENT OF MOTOR NEURON DISEASES AND NEUROMUSCULAR JUNCTION DISORDERS
    Publication number: 20230364076
    Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, for use in the treatment and/or prevention of motor neuron diseases and neuromuscular junction disorders.
    Type: Application
    Filed: October 7, 2021
    Publication date: November 16, 2023
    Inventors: Noëlle CALLIZOT, Cécilia ESTRELLA, Mathieu BARRIER, Philippe VERWAERDE
  • Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same
    Patent number: 10772884
    Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: September 15, 2020
    Assignees: Alzprotect, Universite De Lille 2 Droit Et Sante, INSERM (Institut National De La Sante Et De La Recherche)
    Inventors: Stéphane Burlet, Cécilia Estrella, Mathieu Barrier, Patricia Melnyk, Nicolas Sergeant, Luc Buee, Philippe Verwaerde
  • Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same
    Patent number: 10537569
    Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: January 21, 2020
    Assignees: ALZPROTECT, Universite de Lille 2 Droit et Saute, Inserm (Institut National De La Saute et de la Recherche Medicale
    Inventors: Stéphane Burlet, Cécilia Estrella, Mathieu Barrier, Patricia Melnyk, Nicolas Sergeant, Luc Buee, Philippe Verwaerde
  • SULPHATE SALTS OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[d]IMIDAZOL-2-AMINE, PREPARATION THEREOF AND USE OF THE SAME
    Publication number: 20190381036
    Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
    Type: Application
    Filed: August 27, 2019
    Publication date: December 19, 2019
    Inventors: Stéphane BURLET, Cécilia ESTRELLA, Mathieu BARRIER, Patricia MELNYK, Nicolas SERGEANT, Luc BUEE, Philippe VERWAERDE
  • Carboline compounds usable in the treatment of neurodegenerative diseases
    Patent number: 9714245
    Abstract: The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: July 25, 2017
    Assignees: ALZPROTECT, UNIVERSITE DE LILLE 2 DROIT ET SANTE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Patricia Melnyk, Pascal Carato, Stephane Burlet, Emilie Nguyen, Philippe Verwaerde, Nicolas Sergeant, Cecilia Estrella
  • SULPHATE SALTS OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[d]IMIDAZOL-2-AMINE, PREPARATION THEREOF AND USE OF THE SAME
    Publication number: 20170151235
    Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
    Type: Application
    Filed: December 22, 2016
    Publication date: June 1, 2017
    Inventors: Stéphane BURLET, Cécilia ESTRELLA, Mathieu BARRIER, Patricia MELNYK, Nicolas SERGEANT, Luc BUEE, Philippe VERWAERDE
  • Sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine, preparation thereof and use of the same
    Patent number: 9562018
    Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
    Type: Grant
    Filed: December 27, 2013
    Date of Patent: February 7, 2017
    Assignee: Alzprotect
    Inventors: Stéphane Burlet, Cécilia Estrella, Mathieu Barrier, Patricia Melnyk, Nicolas Sergeant, Luc Buee, Philippe Verwaerde
  • Carboline Compounds Usable in The Treatment of Neurodegenerative Diseases
    Publication number: 20160152610
    Abstract: The present invention relates to a compound according to Formula (A) or a pharmaceutically acceptable salt, solvate, clathrate, hydrate or polymorph thereof, and its use.
    Type: Application
    Filed: June 27, 2014
    Publication date: June 2, 2016
    Inventors: Patricia MELNYK, Pascal CARATO, Stephane BURLET, Emilie NGUYEN, Philippe VERWAERDE, Nicolas SERGEANT, Cecilia ESTRELLA
  • SULPHATE SALTS OF N-(3-(4-(3-(DIISOBUTYLAMINO)PROPYL)PIPERAZIN-1-YL)PROPYL)-1H-BENZO[d]IMIDAZOL-2-AMINE, PREPARATION THEREOF AND USE OF THE SAME
    Publication number: 20160108003
    Abstract: The present invention relates to sulphate salts of N-(3-(4-(3-(diisobutylamino)propyl)piperazin-1-yl)propyl)-1H-benzo[d]imidazol-2-amine and pharmaceutically acceptable solvates thereof, preparation thereof, pharmaceutical compositions containing them and use of the same in the treatment and/or prevention of neurodegenerative diseases.
    Type: Application
    Filed: December 27, 2013
    Publication date: April 21, 2016
    Applicant: Alzproject
    Inventors: Stéphane BURLET, Cécilia ESTRELLA, Mathieu BARRIER, Patricia MELNYK, Nicolas SERGEANT, Luc BUEE, Philippe VERWAERDE
  • Assay techniques using nematode worms
    Patent number: 7083947
    Abstract: Improved techniques for performing assays using nematode worms, such as nematode worms from the genus Caenorhabditis. The assays generally comprise exposing nematodes to at least one compound which paralyzes or kills the nematodes.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: August 1, 2006
    Assignee: Devgen NV
    Inventors: Philippe Verwaerde, Gwladys Cuvillier
  • strain HD8: a mutant exhibiting constitutive pharyngeal pumping
    Patent number: 7030290
    Abstract: The invention provides methods of screening compounds for potential pharmacological activity using nematode worms, principally but not exclusively the nematode C. elegans. Specifically, the invention relates to the use of nematodes modified to have certain characteristics which provide advantages for compound screening, such as constitutive pharyngeal pumping, increased gut permeability or altered gut molecular transport. Methods for selecting suitably modified nematodes from a population of nematodes are also provided.
    Type: Grant
    Filed: August 11, 2003
    Date of Patent: April 18, 2006
    Assignee: Devgen NV
    Inventors: Philippe Verwaerde, Richard Feichtinger, Myriam Behgyn, Thierry Bogaert
  • Compound screening method
    Publication number: 20040250299
    Abstract: The invention relates to screening methods using nematode worms, particularly but not exclusively C. elegans, which are adapted to be performed in a high-throughput format.
    Type: Application
    Filed: April 2, 2004
    Publication date: December 9, 2004
    Applicant: Devgen NV
    Inventors: Philippe Verwaerde, Christ Platteeuw, Gwladys Cuvillier, Thierry Bogaert
  • Compound screening method
    Patent number: 6787125
    Abstract: The invention relates to screening methods using nematode worms, particularly but not exclusively C. elegans, which are adapted to be performed in a high-throughput format.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: September 7, 2004
    Assignee: Devgen NV
    Inventors: Philippe Verwaerde, Christ Platteeuw, Gwladys Cuvillier, Thierry Bogaert
  • Assay techniques based on growth stage dependent expression inc. elegans
    Publication number: 20040073956
    Abstract: This invention is directed to new methods to perform assays with nematodes, and more particularly with microscopic nematodes such as C. elegans. In particular, the invention provides methods based on the use of growth-stage specific promoters to drive growth-stage specific gene expression.
    Type: Application
    Filed: July 11, 2003
    Publication date: April 15, 2004
    Inventors: Philippe Verwaerde, Thierry Bogaert
  • Lipid uptake assays
    Patent number: 6703214
    Abstract: The invention relates to the use of microscopic nematodes such as C. elegans in functional high throughput in vivo assays suitable for the detection of inhibitors or activators of intestinal lipid uptake.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: March 9, 2004
    Assignee: Devgen NV
    Inventors: Philippe Verwaerde, Cindy Anthonissen, Benoit Deprez, Beatrice Bonnet, Thierry Bogaert
  • Method and technology for high-throughput lead profiling
    Publication number: 20040038227
    Abstract: The present invention is related to a method for high-throughput lead and the use of microcalorimetric devices therein.
    Type: Application
    Filed: June 16, 2003
    Publication date: February 26, 2004
    Inventors: Philippe Verwaerde, Katarina Verhaegen
  • Compound assay
    Publication number: 20040034880
    Abstract: The invention provides methods of screening compounds for potential pharmacological activity using nematode worms, principally but not exclusively the nematode C. elegans. Specifically, the invention relates to the use of nematodes modified to have certain characteristics which provide advantages for compound screening, such as constitutive pharyngeal pumping, increased gut permeability or altered gut molecular transport. Methods for selecting suitably modified nematodes from a population of nematodes are also provided.
    Type: Application
    Filed: August 11, 2003
    Publication date: February 19, 2004
    Applicant: Devgen NV
    Inventors: Philippe Verwaerde, Richard Feichtinger, Myriam Behgyn, Thierry Bogaert
  • Compound assay
    Patent number: 6664441
    Abstract: The invention provides methods of screening compounds for potential pharmacological activity using nematode worms, principally but not exclusively the nematode C. elegans. Specifically, the invention relates to the use of nematodes modified to have certain characteristics which provide advantages for compound screening, such as constitutive pharyngeal pumping, increased gut permeability or altered gut molecular transport. Methods for selecting suitably modified nematodes from a population of nematodes are also provided.
    Type: Grant
    Filed: April 14, 2000
    Date of Patent: December 16, 2003
    Assignee: Devgen NV
    Inventors: Philippe Verwaerde, Richard Feichtinger, Myriam Behgyn, Thierry Bogaert
  • Assay techniques using nematode worms
    Publication number: 20030190597
    Abstract: Improved techniques for performing assays using nematode worms, such as nematode worms from the genus Caenorhabditis. The assays generally comprise exposing nematodes to at least one compound which paralyses or kills the nematodes.
    Type: Application
    Filed: June 6, 2003
    Publication date: October 9, 2003
    Inventors: Philippe Verwaerde, Gwladys Cuvillier
  • Compound screening method
    Publication number: 20030154501
    Abstract: The invention provides methods for screening of chemical substances with potential pharmacological activity using nematode worms such as Caenorhabditis elegans, Specifically, the invention relates to methods adapted for high-throughput screening which are performed in a multi-well plate format.
    Type: Application
    Filed: August 7, 2002
    Publication date: August 14, 2003
    Applicant: Devgen, N.V.
    Inventors: Philippe Verwaerde, Thierry Bogaert, Christ Platteeuw, Gwladys Cuvillier, Myriam Behgyn, Richard Feichtinger