Abstract: The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. In particular, the present disclosure relates to N-demethylation of oxymorphone-3,14-diacetate or 14-hydroxymorphinone-3,14-diacetate using highly active catalytic palladium (0) in a continuous flow system under elevated temperature and pressure condition. The methodology can be utilized towards the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation.

Abstract: The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer.

Abstract: The present disclosure relates to N-demethylation of a compound containing a tertiary N-methylamine, including for example a morphinan alkaloid, in a continuous flow system. In particular, the present disclosure relates to N-demethylation of oxymorphone-3,14-diacetate or 14-hydroxymorphinone-3,14-diacetate using highly active catalytic palladium (0) in a continuous flow system under elevated temperature and pressure condition. The methodology can be utilized towards the synthesis of noroxymorphone via aerobic palladium-catalyzed continuous flow N-demethylation.

Abstract: The present invention relates to processes useful in the preparation of morphine analogs and derivatives, such as naltrexone, naloxone and nalbuphine and intermediates in the synthesis of said morphine analogs and derivatives. In a particular example, the process begins with for example oxymorphone, oxycodone, 14-hydroxycodeinone or 14-hydroxymorphinone, and includes the formation of an oxazolidine-containing intermediate using catalytic oxidation.

Abstract: The present disclosure relates to selective reduction of morphinan alkaloids in a continuous flow system. In particular, the present disclosure relates to selective reduction of thebaine or oripavine using hydrazine or a hydrazine-containing compound in a continuous flow system under elevated temperature and pressure condition to form 8,14-dihydrothebaine or 8,14-dihydrooripavine, respectively.

Abstract: The present disclosure relates to selective reduction of morphinan alkaloids in a continuous flow system. In particular, the present disclosure relates to selective reduction of thebaine or oripavine using hydrazine or a hydrazine-containing compound in a continuous flow system under elevated temperature and pressure condition to form 8,14-dihydrothebaine or 8,14-dihydrooripavine, respectively.

Abstract: The present invention is directed to processes for the preparation of lisdexamfetamine and related derivatives, wherein the processes comprise coupling to racemic or enantiomerically enriched amphetamine and wherein the resulting product is advantageously enantiomerically or diastereomerically enriched in the desired stereoisomer.

Abstract: The present invention is directed to a method for the extraction and/or enrichment of alkaloids from a mixture containing such compounds. More particularly, the present invention is directed to methods for extracting one or more alkaloids using dimethyl ether.

Abstract: An image capturing system includes: a plurality of image capturing devices, wherein each image capturing device is adapted to capture an image of an object and transmit the captured image; and a processor in communication with each of the image capturing devices, the processor adapted to transmit a, control signal to each of the image capturing devices, receive each of the captured images, process the captured images, and transmit the processed captured images, wherein the processing of the captured images includes combining the images to appear as a seamless single rotational image.

Abstract: A firearm sight receives information regarding a factor, and then automatically adjusts the relative positions of a digital reticle and an image on a viewing section to compensate for the influence of the factor on a projectile trajectory. A different feature involves automatically adjusting a characteristic of the reticle based on the image. Another feature involves automatically adjusting the digital image to distinguish a portion thereof aligned with the reticle from an adjacent portion thereof. Yet another feature involves causing the firearm sight to generate an audible sound. Still another feature involves presenting information on the viewing section which represents the position of the firearm sight on the surface of the earth.

Abstract: A firearm sight receives information regarding a factor, and then automatically adjusts the relative positions of a digital reticle and an image on a viewing section to compensate for the influence of the factor on a projectile trajectory. A different feature involves automatically adjusting a characteristic of the reticle based on the image. Another feature involves automatically adjusting the digital image to distinguish a portion thereof aligned with the reticle from an adjacent portion thereof. Yet another feature involves causing the firearm sight to generate an audible sound. Still another feature involves presenting information on the viewing section which represents the position of the firearm sight on the surface of the earth.

Abstract: The present invention is directed to processes for preparing oxycodone base and oxycodone hydrochloride compositions having less than 10 ppm of 14-hydroxycodeinone.

Abstract: The present invention provides a method for the N-demethylation and/or N-acylation of an N-methylated heterocycle such as morphine alkaloids or tropane alkaloids. The method comprises reacting the heterocycle with an acylating agent in the presence of a metal catalyst.

Abstract: The present invention is directed to processes for preparing oxycodone base and oxycodone hydrochloride compositions having less than 10 ppm of 14-hydroxycodeinone.

Abstract: The present invention is directed to processes for preparing oxycodone base and oxycodone hydrochloride compositions having less than 10 ppm of 14-hydroxycodeinone.

Abstract: The present invention is directed to a process for using n-butanol to prepare an oxycodone base compositions having reduced levels of impurities such as 14-hydroxycodeinone and DHDHC.

Abstract: An image capturing system including a plurality of image capturing stations, wherein each of the image capturing stations captures a first image and a second image of an object and transmits the captured images, the first image and the second image of the object being from different perspectives; and a processor in communication with each of the image capturing stations, the processor adapted to transmit a control signal to each of the image capturing stations, receive each of the captured images, process the captured images, and transmit the processed captured images, wherein the processing of the captured images includes combining the images to appear as a seamless single rotational image viewable in at least one of a two-dimensional and a three-dimensional format.

Abstract: The present invention provides compositions comprising particles comprising a poorly soluble opioid drug and a stabilizer, wherein the particles have an average diameter of less than about 10,000 nm. Methods of making the compositions and their use as pharmaceutical compositions for treating disorders such as pain are also described.

Abstract: An image capturing system includes: a plurality of image capturing devices, wherein each image capturing device is adapted to capture an image of an object and transmit the captured image; and a processor in communication with each of the image capturing devices, the processor adapted to transmit a, control signal to each of the image capturing devices, receive each of the captured images, process the captured images, and transmit the processed captured images, wherein the processing of the captured images includes combining the images to appear as a seamless single rotational image.

Abstract: Oxycodone.HCl polymorph forms are disclosed which are useful as analgesic agents either in combination with or as replacements for oxycodone.