Patents by Inventor Phillip A. Patten

Phillip A. Patten has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20090017500
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: October 30, 2006
    Publication date: January 15, 2009
    Inventors: Phillip A. Patten, Sridhar Govindarajan, Sridhar Viswanathan, Torben Lauesgaard Nissen
  • NOVEL GLYPHOSATE-N-ACETYLTRANSFERASE (GAT) GENES
    Publication number: 20090011938
    Abstract: Methods and compositions for improving yield in a plant are provided. Methods of improving yield include treating plants with an effective amount of glyphosate, wherein the plant express at least two heterologous polypeptides that impart tolerance to glyphosate via distinct modes of action. In one non-limiting method, the first polypeptide has glyphosate N-acetyl transferase activity and the second polypeptide comprises a glyphosate-tolerant EPSPS polypeptide.
    Type: Application
    Filed: May 30, 2008
    Publication date: January 8, 2009
    Applicants: Pioneer Hi--Bred International, Inc., E.I. du Pont de Nemours and Company
    Inventors: Linda A. Castle, Yong Hong Chen, Nicholas B. Duck, Lorraine Giver, Cristina Ivy, Roger Kemble, Billy Fred McCutchen, Jeremy Minshull, Phillip A. Patten, Dan Siehl
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20090011465
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: October 30, 2006
    Publication date: January 8, 2009
    Inventors: Phillip A. Patten, Sridhar Govindarajan, Sridhar Viswanathan, Torben Lauesgaard Nissen
  • Methods for making character strings, polynucleotides and polypeptides having desired characteristics
    Publication number: 20080318795
    Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
    Type: Application
    Filed: October 31, 2007
    Publication date: December 25, 2008
    Applicant: Maxygen, Inc.
    Inventors: Sergey A. Selifonov, Willem P.C. Stemmer, Claes Gustafsson, Matthew Tobin, Stephen del Cardayre, Phillip A. Patten, Jeremy Minshull, Lorraine J. Giver
  • Integrated system for diversity generation and screening
    Patent number: 7462469
    Abstract: Integrated systems and methods for diversity generation and screening are provided. The systems use common fluid and array handling components to provide nucleic acid diversification, transcription, translation, product screening and subsequent diversification reactions.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: December 9, 2008
    Assignee: Maxygen, Inc.
    Inventors: Steven H. Bass, S. Christopher Davis, Phillip A. Patten, Matthew Tobin, Jeremy Minshull, Mark Welch, Claes Gustafsson, Brian Carr, Stephane Jenne, Sun Ai Raillard, Andreas Crameri, Willem P. C. Stemmer, Robin Emig, Pascal Longchamp, Stanley Goldman, Lorraine J. Giver, Joseph A. Affholter
  • Glyphosate N-acetyltransferase (GAT) genes
    Patent number: 7462481
    Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: December 9, 2008
    Assignees: Verdia, Inc., Pioneer Hi-Bred Int'l., Inc., E.I. du Pont de Nemours
    Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Christina Ivy, Yong Hong Chen, Phillip A. Patten, Rebecca Gorton, Nicholas B. Duck, Billy Fred McCutchen, Roger Kemble
  • Novel glyphosate-N-acetyltransferase (GAT) genes
    Publication number: 20080248547
    Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.
    Type: Application
    Filed: December 19, 2006
    Publication date: October 9, 2008
    Applicants: Verdia Inc., Pioneer Hi-Bred International, Inc., E.I.du Pont de Nemours and Company
    Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Christina Ivy, Yong Hong Chen, Phillip A. Patten, Rebecca Gorton, Nicholas B. Duck, Billy Fred McCutchen, Roger Kemble
  • NOVEL GLYPHOSATE-N-ACETYLTRANSFERASE (GAT) GENES
    Publication number: 20080241927
    Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.
    Type: Application
    Filed: March 21, 2008
    Publication date: October 2, 2008
    Applicants: Verdia Inc., Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANY
    Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Christina Ivy, Yong Hong Chen, Phillip A. Patten, Rebecca Gorton, Nicholas B. Duck, Billy Fred McCutchen, Roger Kemble
  • EVOLVED INTERFERON-ALPHA POLYPEPTIDES
    Publication number: 20080226597
    Abstract: The present invention provides evolved interferon-alpha polypeptides, and conjugates thereof, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: May 17, 2006
    Publication date: September 18, 2008
    Applicant: MAXYGEN, INC.
    Inventors: Madan M. PAIDHUNGAT, Ian J. SAS, Thomas BOUQUIN, David LIN, Teddy CHEN, Douglas GUPTILL, Amy BRIDEAU-ANDERSEN, Steven H. BASS, Phillip A. PATTEN
  • Interferon-Alpha Polypeptides and Conjugates
    Publication number: 20080227149
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: October 25, 2007
    Publication date: September 18, 2008
    Inventors: Phillip A. Patten, Sridhar Govindarajan, Sridhar Viswanathan, Torben Lauesgaard Nissen
  • Identifying oligonucleotides for in vitro recombination
    Patent number: 7421347
    Abstract: “In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
    Type: Grant
    Filed: March 7, 2005
    Date of Patent: September 2, 2008
    Assignee: Maxygen, Inc.
    Inventors: Sergey A. Selifonov, Willem P. C. Stemmer, Claes Gustafsson, Matthew Tobin, Stephen del Cardayre, Phillip A. Patten, Jeremy Minshull
  • ANTIBODY DIVERSITY GENERATION
    Publication number: 20080207459
    Abstract: Methods for improving antibodies by a variety of DNA diversification and selection procedures are provided. Improvements include increases in affinity, alterations in specificity and effector function, as well as reduced antigenicity, e.g. humanization. Libraries of recombinant antibody sequences are provided, as are cells expressing members of such libraries. Novel phage display vectors are provided. Methods for the coevolution of an antibody and its cognate antigen are provided. Coevolution is used to evolve HIV envelope proteins with increased antigenicity and broadly neutralizing antibodies that interact therewith. Methods of improving antibodies for use in the detection of biological warfare agents are provided.
    Type: Application
    Filed: February 5, 2008
    Publication date: August 28, 2008
    Inventors: Erik Karrer, Steven H. Bass, Robert Whalen, Phillip A. Patten
  • Glyphosate-N-acetyltransferase (GAT) genes
    Patent number: 7405074
    Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: July 29, 2008
    Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and Company, Verdia Inc.
    Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Christina Ivy, Yong Hong Chen, Phillip A. Patten, Rebecca Gorton, Nicholas B. Duck, Billy Fred McCutchen, Roger Kemble
  • Oligonucleotide mediated nucleic acid recombination
    Publication number: 20080171668
    Abstract: Methods of recombining nucleic acids, including homologous nucleic acids, are provided. Families of gene shuffling oligonucleotides and their use in recombination procedures, as well as polymerase and ligase mediated recombination methods are also provided.
    Type: Application
    Filed: November 30, 2007
    Publication date: July 17, 2008
    Applicant: Maxygen, Inc.
    Inventors: Andreas Crameri, Willem P.C. Stemmer, Jeremy Minshull, Steven H. Bass, Mark Welch, Jon E. Ness, Claes Gustafsson, Phillip A. Patten
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20080171363
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: August 14, 2007
    Publication date: July 17, 2008
    Inventors: Phillip A. Patten, Sridhar Viswanathan, Torben Lauesgaard Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski
  • Methods, systems, and software for identifying functional biomolecules
    Publication number: 20080133143
    Abstract: The present invention generally relates to methods of rapidly and efficiently searching biologically-related data space. More specifically, the invention includes methods of identifying bio-molecules with desired properties, or which are most suitable for acquiring such properties, from complex bio-molecule libraries or sets of such libraries. The invention also provides methods of modeling sequence-activity relationships. As many of the methods are computer-implemented, the invention additionally provides digital systems and software for performing these methods.
    Type: Application
    Filed: October 30, 2007
    Publication date: June 5, 2008
    Applicant: MAXYGEN, INC
    Inventors: Claes Gustafsson, Sridhar Govindarajan, Robin A. Emig, Richard John Fox, Ajoy K. Roy, Jeremy S. Minshull, S. Christopher Davis, Anthony R. Cox, Phillip A. Patten, Linda A. Castle, Daniel L. Siehl, Rebecca Lynne Gorton, Teddy Chen
  • Novel glyphosate-N-acetyltransferase (GAT) genes
    Publication number: 20080119639
    Abstract: Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.
    Type: Application
    Filed: August 16, 2006
    Publication date: May 22, 2008
    Inventors: Linda A. Castle, Dan Siehl, Lorraine Giver, Jeremy Minshull, Cristina Ivy, Yong Hong Chen, Phillip A. Patten, Nicholas B. Duck
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20080076710
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: May 4, 2007
    Publication date: March 27, 2008
    Inventors: Phillip Patten, Sridhar Viswanathan, Torben Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski
  • Methods for making character strings, polynucleotides and polypeptides having desired characteristics
    Publication number: 20080050782
    Abstract: In silico nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided.
    Type: Application
    Filed: October 18, 2007
    Publication date: February 28, 2008
    Applicant: Maxygen, Inc.
    Inventors: Sergey Selifonov, Willem Stemmer, Claes Gustafsson, Matthew Tobin, Stephen Cardayre, Phillip Patten, Jeremy Minshull, Lorraine Giver
  • INTERFERON-ALPHA POLYPEPTIDES AND CONJUGATES
    Publication number: 20080031853
    Abstract: The present invention provides interferon-alpha polypeptides and conjugates, and nucleic acids encoding the polypeptides. The invention also includes compositions comprising these polypeptides, conjugates, and nucleic acids; cells containing or expressing the polypeptides, conjugates, and nucleic acids; methods of making the polypeptides, conjugates, and nucleic acids; and methods of using the polypeptides, conjugates, and nucleic acids.
    Type: Application
    Filed: August 15, 2007
    Publication date: February 7, 2008
    Inventors: Phillip Patten, Sridhar Viswanathan, Torben Nissen, Anne Vogt, Harald Kropshofer, Ralf Schumacher, Stephan Fischer, Stefan Seeber, Adelbert Grossmann, Friederike Hesse, Andreas Schaubmar, Roberto Falkenstein, Hans Koll, Markus Dembowski