Abstract: The present disclosure provides modules, instruments and methods to enrich for cells edited via nucleic acid-guided nuclease editing of live cells.

Abstract: The invention relates to a method for operating an electric machine (2) comprising a rotatably mounted rotor and a motor winding that is electrically connected to an electrical energy store (4) by means of a power electronics (3). In said method, the machine (2) and/or an apparatus comprising the machine (2) is/are monitored in respect of fault events, and the motor winding is short-circuited by triggering the power electronics (3) upon detection of a fault event.

Abstract: The invention relates to a method for operating an electric machine (2), in particular in a motor vehicle, the machine (2) comprising a rotatably mounted rotor and a motor winding that is electrically connected to an electrical energy store (4) by means of a power electronics (3). In said method, by triggering the power electronics (3), the electric machine (2) is controlled in a field-oriented manner in such a way that the machine (2) generates a specified desired torque (Ttarget). According to the invention, when it is ascertained that based on a current actual working point (AP1) of the electric machine (2) a specified desired working point (AP2) of the electric machine (2) should be set at least substantially in a time-optimized manner, a predicted pilot control action is specified, and that the desired working point (AP2) is set by triggering the power electronics (3) according to the predicted pilot control action.

Abstract: An analog hashing system and method includes: an input port for accepting an input signal; a chaotic circuit including non-linear components and multiple chaotic attractors for generating an unpredictable output responsive to the input signal; a differential output port coupled to the chaotic circuit for producing an analog differential signal from the unpredictable output; and a clock circuit for producing a binary output, as a hash function, generated by the sign of the analog output in every clock cycle.

Abstract: An analog hashing system and method includes: an input port for accepting an input signal; a chaotic circuit including non-linear components and multiple chaotic attractors for generating an unpredictable output responsive to the input signal; a differential output port coupled to the chaotic circuit for producing an analog differential signal from the unpredictable output; and a clock circuit for producing a binary output, as a hash function, generated by the sign of the analog output in every clock cycle.

Abstract: Method for searching an item using a parametric hash filter includes forming an input vector from input data stream; forming a hash matrix having a first portion and a second portion; multiplying the hash matrix with the input vector to generate a second input vector including a hash values of the first input vector; generating a perfect hash vector and a universal hash vector, by applying a smooth periodic function to the second input vector; mapping onto a Markov random field the coordinates of locations of hash values in a search domain for which there is no possibility of collisions in the perfect hash vector to form an energy function; minimizing the energy function to generate a compressed hash table; fitting a band of acceptable locations in the compressed hash table, based on a predetermined false positive rate; and searching for a new item in the band of acceptable locations.

Abstract: A reservoir computer. In some embodiments, the reservoir computer includes a discrete element transmission line and a readout circuit. The discrete element transmission line may include a plurality of shunt-connected Josephson junctions and a plurality of series-connected inductors connected to the shunt-connected Josephson junctions. The readout circuit may be connected to at least three nodes of the discrete element transmission line.

Abstract: A microwave switch. In some embodiments, the microwave switch includes a substrate, a signal conductor, a first ground conductor, on a first side of the signal conductor, and a second ground conductor, on a second side of the signal conductor. The signal conductor, the first ground conductor, and the second ground conductor may be planar conductors on a planar top surface of the substrate. The signal conductor may have a first portion composed of a superconducting material, and a second portion having a reduced cross section, a cross-sectional area of the second portion being less than 120 nm.

Abstract: The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

Abstract: A microwave switch. In some embodiments, the microwave switch includes a substrate, a signal conductor, a first ground conductor, on a first side of the signal conductor, and a second ground conductor, on a second side of the signal conductor. The signal conductor, the first ground conductor, and the second ground conductor may be planar conductors on a planar top surface of the substrate. The signal conductor may have a first portion composed of a superconducting material, and a second portion having a reduced cross section, a cross-sectional area of the second portion being less than 120 nm.

Abstract: A balanced coverplate for an electrical or communication junction box including an upper portion and a substantially aligned lower portion for storage of items on holding means such as hooks, pegs or magnets. The upper portion of the coverplate may conveniently supplant a standard wall outlet/receptacle cover plate or switch cover plate. The lower portion is primarily intended for storage of items and extends from the lower edge of the upper portion. A main portion plate of the lower portion is intended to guard the wall from contact with the items being stored. The upper and lower portions are substantially aligned with the fasteners captured by the junction box, so torque about each fastener is substantially minimized, thus ensuring the longevity of the fasteners and their respective apertures of the junction box while protecting the wall surface below the outlet and/or switch.

Abstract: The water formulation is a composition of water for brewing such beverages as coffee and tea, for preparing beverages from syrup or concentrate mixed with water, for enhancing carbonated water, and that forms a potable mineral water. The water formulation provides water having Total Dissolved Solids (TDS) of about 150 parts per million (ppm) and about grains of hardness. The TDS include about 6.10 ppm sodium ion (Na+); about 13.00 ppm potassium ion (K+); about 34.00 ppm calcium ion (Ca+2); about 36.54 ppm bicarbonate ion (HCO3?); and about 60.34 ppm chloride ion (Cl?). The water formulation enhances the extraction of components beneficial to, and inhibits the extraction of components detrimental to, the body, acidity, aroma, and taste of brewed beverages and soft drinks while reducing scaling, corrosion, and damage to equipment.

Abstract: An HVAC system comprises a programmable wireless thermostat and a remote receiver unit. The thermostat includes a user interface having one or more displays, user input devices, such as buttons, sliders, or a touch screen, and a backlight. The thermostat may include a proximity sensor, wherein the user interface is controlled based on a user's presence near the thermostat. A thermostat controller enters into a reduced energy consumption mode and switches the user interface to an idle state when the proximity sensor indicates a lack of user proximity for a predetermined duration. When the proximity sensor indicates user proximity, the controller exits the reduced energy consumption mode and switches the user interface to an active state. During the reduced energy consumption mode, the user interface may be concealed when the user interface is in a housing which is transparent when backlit but is opaque otherwise.

Abstract: A thermostat permitting a user to easily access the most commonly used thermostat settings is provided. The thermostat includes a user interface display and a single menu or favorites (FAV) button. A top level menu is displayed on the user interface display when the FAV button is depressed. The top level menu includes a listing of the most commonly used thermostat settings on a single screen. As such, the thermostat user is permitted to easily select one of the commonly used thermostat settings without having to navigate through various different menus or screens. The thermostat also includes a digital version of the user's manual stored therein. This manual may be displayed on the user interface screen. A link to the manual may be provided on the single screen along with the listing of the most commonly used thermostat settings.

Abstract: A thermostat having a terminal connection mechanism and method that provides ease of installation of the thermostat and the heating, ventilating and air conditioning (HVAC) wiring is provided. One embodiment allows any wire to be attached to any terminal. This thermostat includes logic for determining an identity of the wire connected to an HVAC system component. The control logic determines a characteristic of the HVAC system component and compares the characteristic to a known characteristic of the HVAC system component. Environmental responses may also be monitored to identify the HVAC component. The terminal of the thermostat may be color coded to further ease installation. Tool-less terminal connectors may also be used to still further ease installation.

Abstract: A control system for managing a heating, ventilating and air conditioning (HVAC) system based on occupancy of an area is provided. The occupancy may be determined by anticipated programming based on time of day zoning, and/or by actual sensed occupancy. In the later, the control system includes an occupancy sensor that communicates with a programmable thermostat. The occupancy sensor is disposed in the area and senses a state of occupancy of the area. The programmable thermostat instructs the HVAC system to adjust the temperature of the area within the structure based on the state of occupancy of that particular area to enhance occupant comfort and energy efficiency. The thermostat may also include programming modes or scripts that may be run to adjust operational control when abnormal occupancy conditions are sensed. Controllable dampers may also be used by the thermostat to achieve micro zoning control of the HVAC system.

Abstract: The present invention is a blend of a monovinylidene aromatic polymer, a rubber modified monovinylidene aromatic polymer, and a monovinyl aromatic-conjugated diene copolymer, which can be used to produce cost effective, transparent packaging materials with a good toughness, which materials can be produced using conventional thermoforming equipment. The blend comprises: a) from 49 to 70 weight percent based on the total weight of the blend, of a monovinylidene aromatic polymer having a weight average molecular weight (Mw) of from 210,000 to 400,000 and a melt flow of less than 12.0 g/10 min.

Abstract: The present invention is a blend of a monovinylidene aromatic polymer, a rubber modified monovinylidene aromatic polymer, and a monovinyl aromatic-conjugated diene copolymer, which can be used to produce cost effective, transparent packaging materials with a good toughness, which materials can be produced using conventional thermoforming equipment.

Abstract: The present invention is a blend of a monovinylidene aromatic polymer, a rubber modified monovinylidene aromatic polymer, and a monovinyl aromatic-conjugated diene copolymer, which can be used to produce cost effective, transparent packaging materials with a good toughness, which materials can be produced using conventional thermoforming equipment.

Abstract: A polystyrene foam sheet comprising a polystyrene resin which contains 1 to 15 wt. % of a rubber component having a majority of particle sizes less than about 0.45 microns has been found to be superior for forming deep drawn articles. Optionally one or two films may be extrusion coated or laminated to the foam sheet prior to thermoforming. Also disclosed is a method for thermoforming the foam sheet. Preheat the sheet, clamp the sheet between the matched male and female mold members, move the members into final position while applying a vacuum through both members to both sides of the foamed sheet and then chill formed foam to set a final shape.