Abstract: A method for treatment of prostate cancer or benign prostate hyperplasia by combination therapy comprising administering to a patient an androgen-deprivation therapy agent and a bacteriochlorophyll derivative followed by photodynamic therapy (PDT) or vascular-targeted photodynamic therapy (VTP).

Abstract: There is disclosed an implant for anchoring in bone and/or fibrous connective tissue and to which a prosthesis such as a dental bridge may be connected through connecting components. The implant is of tapered design defining a wide top portion for connection to the connecting components and a tapered body comprising upper and lower regions. The lower bone-engaging region of the implant is provided with a porous surface into which bone may grow thereby anchoring the implant. The upper region of the implant has a surface suitable for bone attachment which is different from the surface of the lower region. In one embodiment, the upper portion has a larger taper angle than the rest of the implant for increased stability and stress transfer to the surrounding bone. In another embodiment, the surface of the upper region is coated with a bioreactive coating to allow direct bonding of bone and/or soft connective tissue (gingival tissue) thereby inhibiting epithelial migration apically.