Patents by Inventor Phillip Arcangel
Phillip Arcangel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7319144Abstract: The invention relates to a method of detecting HCV infection in a biological sample, the method comprising providing an immunoassay solid support, comprising an HCV anti-core antibody, an antigen comprising an HCV NS3/4a epitope, and an HCV multiple epitope fusion antigen, that can detect both HCV antigens and antibodies present in a sample. The invention also includes polynucleotides encoding multiple epitope fusion antigens for use in the assay, recombinant vectors and host cells comprising such polynucleotides, and methods of producing the multiple epitope fusion antigens.Type: GrantFiled: August 19, 2003Date of Patent: January 15, 2008Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Patent number: 7241879Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.Type: GrantFiled: July 26, 2004Date of Patent: July 10, 2007Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Patent number: 7166426Abstract: An HCV antigen/antibody/antigen assay is provided. The assay employs an isolated first antigen from a region of the HCV polyprotein, and an HCV multiple epitope fusion antigen that includes an epitope from the same region of the polyprotein as the first antigen. Both the first antigen and the multiple epitope fusion antigen bind antibodies present in an HCV-infected sample.Type: GrantFiled: September 8, 2003Date of Patent: January 23, 2007Assignee: Novartis Vaccines And Diagnostics, Inc.Inventors: Phillip Arcangel, David Chien
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Publication number: 20040265801Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.Type: ApplicationFiled: July 26, 2004Publication date: December 30, 2004Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Publication number: 20040229218Abstract: Immunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C virus, and kits employed therefor are provided.Type: ApplicationFiled: April 7, 2004Publication date: November 18, 2004Applicant: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel
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Patent number: 6815160Abstract: Imnunoassays for detecting hepatitis C virus protein and immune complexes between hepatitis C virus protein and antibodies in biological samples, methods of screening blood products for hepatitis C virus, and kits employed therefor are provided.Type: GrantFiled: January 25, 2002Date of Patent: November 9, 2004Assignee: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel
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Patent number: 6797809Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.Type: GrantFiled: August 8, 2003Date of Patent: September 28, 2004Assignee: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Publication number: 20040142321Abstract: An HCV antigen/antibody/antigen assay is provided. The assay employs an isolated first antigen from a region of the HCV polyprotein, and an HCV multiple epitope fusion antigen that includes an epitope from the same region of the polyprotein as the first antigen. Both the first antigen and the multiple epitope fusion antigen bind antibodies present in an HCV-infected sample.Type: ApplicationFiled: September 8, 2003Publication date: July 22, 2004Inventors: Phillip Arcangel, David Chien
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Publication number: 20040096822Abstract: An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.Type: ApplicationFiled: August 19, 2003Publication date: May 20, 2004Applicant: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Publication number: 20040063092Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.Type: ApplicationFiled: August 8, 2003Publication date: April 1, 2004Applicant: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Patent number: 6632601Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.Type: GrantFiled: June 14, 2001Date of Patent: October 14, 2003Assignee: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Patent number: 6630298Abstract: An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.Type: GrantFiled: June 14, 2001Date of Patent: October 7, 2003Assignee: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Publication number: 20030170618Abstract: The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.Type: ApplicationFiled: January 28, 2003Publication date: September 11, 2003Inventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler
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Patent number: 6537745Abstract: The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.Type: GrantFiled: February 2, 2001Date of Patent: March 25, 2003Assignee: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler
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Publication number: 20020192639Abstract: An HCV core antigen and NS3/4a antibody combination assay that can detect both HCV antigens and antibodies present in a sample using a single solid matrix, is provided, as well as immunoassay solid supports for use in the assay.Type: ApplicationFiled: June 14, 2001Publication date: December 19, 2002Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Publication number: 20020146685Abstract: HCV immunoassays comprising an NS3/4a conformational epitope and a multiple epitope fusion antigen are provided, as well as immunoassay solid supports for use with the immunoassays.Type: ApplicationFiled: June 14, 2001Publication date: October 10, 2002Inventors: David Y. Chien, Phillip Arcangel, Laura Tandeske, Carlos George-Nascimento, Doris Coit, Angelica Medina-Selby
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Patent number: 6391540Abstract: The present invention is directed to assays for detecting antibodies in a sample in a single incubation step. The assays employ universal solid phases and/or universal detectable markers, and facilitate the detection and differentiation of antigens from the same source or from different sources in a single test sample. The present invention includes test kits for performing the methods according to the invention.Type: GrantFiled: September 22, 1998Date of Patent: May 21, 2002Assignee: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler
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Publication number: 20010039009Abstract: The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.Type: ApplicationFiled: February 2, 2001Publication date: November 8, 2001Applicant: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler
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Patent number: 6261764Abstract: The present invention is directed to an antigen diluent or buffer for antigens, in particular HCV recombinant antigens, comprising a reducing agent. The antigen diluent or buffer serves as a stabilizing buffer for the antigens. The present invention is also directed to antigen diluents or buffers for use in an automated immunoassay.Type: GrantFiled: September 22, 1998Date of Patent: July 17, 2001Assignee: Chiron CorporationInventors: David Y. Chien, Phillip Arcangel, Stephen Tirell, Wanda Zeigler