Patents by Inventor Phillip B. Messersmith

Phillip B. Messersmith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10676509
    Abstract: Immobilizable antimicrobial compounds incorporating antimicrobial and/or antifouling components, as can be adhered to various device structures and components.
    Type: Grant
    Filed: July 31, 2009
    Date of Patent: June 9, 2020
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Annelise E. Barron, Andrea Statz, Nathaniel Chongslriwatana
  • Publication number: 20190381031
    Abstract: Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.
    Type: Application
    Filed: June 3, 2019
    Publication date: December 19, 2019
    Inventors: Phillip B. Messersmith, Iossif A. Strehin, Ellen Heber-Katz
  • Publication number: 20190177182
    Abstract: A bio-inspired method for detoxifying contaminated water is disclosed. In the method, polydopamine, a mussel-inspired adhesive catecholamine was used as an adsorbent to effectively remove from contaminated water three major classes of toxic agents: heavy metal ions (e.g., Cr, Hg, Pb, Cu, and Cd), toxic organic species (e.g., 4-aminopyridine), and radioisotopes (e.g., Lutetium-177). Furthermore, the polydopamine adsorbent was regenerated by treatment with acid or hydrogen peroxide.
    Type: Application
    Filed: October 8, 2018
    Publication date: June 13, 2019
    Inventors: Phillip B. Messersmith, Haeshin Lee
  • Patent number: 10307415
    Abstract: Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.
    Type: Grant
    Filed: June 9, 2017
    Date of Patent: June 4, 2019
    Assignees: Northwestern University, The Wistar Institute of Anatomy and Biology
    Inventors: Phillip B. Messersmith, Iossif A. Strehin, Ellen Heber-Katz
  • Patent number: 10265275
    Abstract: A method of making a facile, surface-independent, polyphenol coating is disclosed. In general, the method includes contacting at least a portion of the substrate to be coated with an aqueous solution containing one or more salts and one or more nitrogen-free phenolic compounds. Substrates of all kinds may be used, and compounds used to make the coating may include epigallocatechin-3-gallate (EGCG), epigallocatechin (EGC) and epicatechin-3-gallate (ECG), tannic acid, gallic acid, pyrogallol, and/or other nitrogen-free phenolic compounds. The coating made using the method, methods of using the coating, and kits comprising the coating precursors are also disclosed.
    Type: Grant
    Filed: February 24, 2014
    Date of Patent: April 23, 2019
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Tadas S. Sileika, Ran Zhang, Devin G. Barrett
  • Publication number: 20190085185
    Abstract: The disclosure provides for coating compositions comprising macrocycles and salts in aqueous buffer and the use of the coating composition to prevent absorption of small molecules into polymeric surfaces.
    Type: Application
    Filed: February 22, 2017
    Publication date: March 21, 2019
    Inventors: Kevin Healy, Phillip B. Messersmith, Willie Mae Reese, Patrick Burch
  • Publication number: 20190016901
    Abstract: The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality.
    Type: Application
    Filed: September 14, 2018
    Publication date: January 17, 2019
    Inventors: Phillip B. Messersmith, Haeshin Lee
  • Patent number: 10179114
    Abstract: A method of making a facile, surface-independent, polyphenol coating is disclosed. In general, the method includes contacting at least a portion of the substrate to be coated with an aqueous solution containing one or more salts and one or more nitrogen-free phenolic compounds. Substrates of all kinds may be used, and compounds used to make the coating may include epigallocatechin-3-gallate (EGCG), epigallocatechin (EGC) and epicatechin-3-gallate (ECG), tannic acid, gallic acid, pyrogallol, and/or other nitrogen-free phenolic compounds. The coating made using the method, methods of using the coating, and kits comprising the coating precursors are also disclosed.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: January 15, 2019
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Tadas S. Sileika, Ran Zhang, Devin G. Barrett
  • Publication number: 20190008965
    Abstract: The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.
    Type: Application
    Filed: July 9, 2018
    Publication date: January 10, 2019
    Inventors: Phillip B. Messersmith, Kvar C.L. Black, Ji Yi, Jose G. Rivera
  • Patent number: 10106690
    Abstract: The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: October 23, 2018
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Phillip B. Messersmith, Haeshin Lee
  • Patent number: 10093557
    Abstract: A bio-inspired method for detoxifying contaminated water is disclosed. In the method, polydopamine, a mussel-inspired adhesive catecholamine was used as an adsorbent to effectively remove from contaminated water three major classes of toxic agents: heavy metal ions (e.g., Cr, Hg, Pb, Cu, and Cd), toxic organic species (e.g., 4-aminopyridine), and radioisotopes (e.g., Lutetium-177). Furthermore, the polydopamine adsorbent was regenerated by treatment with acid or hydrogen peroxide.
    Type: Grant
    Filed: April 4, 2016
    Date of Patent: October 9, 2018
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Phillip B. Messersmith, Haeshin Lee
  • Patent number: 10016499
    Abstract: The present invention provides nanoparticles including a metallic core having a length along each axis of from 1 to 100 nanometers and a coating disposed on at least part of the surface of the metallic core, wherein the coating comprises polydopamine, along with methods for making and using such nanoparticles. The metallic core may be gold, silver or iron oxide and the polydopamine coating may have other substances bound to it, such as silver, targeting ligands or antibodies, or other therapeutic or imaging contrast agents. The disclosed nanoparticles can be targeted to cells for treating cancer or bacterial infections, and for use in diagnostic imaging.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: July 10, 2018
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Kvar C. L. Black, Ji Yi, Jose G. Rivera
  • Publication number: 20170273971
    Abstract: Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Inventors: Phillip B. Messersmith, lossif A. Strehin, Ellen Heber-Katz
  • Patent number: 9687582
    Abstract: The present invention provides adhesive hydrogels that negatively swell at physiological temperature. By combining mussel-mimetic chemistry and the thermosensitive nature of poly(ethylene oxide)-poly(propylene oxide) copolymers, novel materials were designed that are suitable as medical sealants and adhesives.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: June 27, 2017
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Devin G. Barrett
  • Publication number: 20170166756
    Abstract: The present invention provides a surface-independent surface-modifying multifunctional biocoating and methods of application thereof. The method comprises contacting at least a portion of a substrate with an alkaline solution comprising a surface-modifying agent (SMA) such as dopamine so as to modify the substrate surface to include at least one reactive moiety. In another version of the invention, a secondary reactive moiety is applied to the SMA-treated substrate to yield a surface-modified substrate having a specific functionality.
    Type: Application
    Filed: June 9, 2016
    Publication date: June 15, 2017
    Inventors: Phillip B. Messersmith, Haeshin Lee
  • Patent number: 9675607
    Abstract: Methods and compositions are described for enhancing tissue regeneration or wound repair in a mammalian subject comprising a composition comprising (a) a proline hydroxylase inhibitor component or molecule that increases or upregulates HIF1a and (b) a carrier component comprising a hydrogel.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: June 13, 2017
    Assignees: Northwestern University, The Wistar Institute of Anatomy and Biology
    Inventors: Phillip B. Messersmith, Iossif A. Strehin, Ellen Heber-Katz
  • Publication number: 20170129999
    Abstract: Biocompatible hydrogels made from cross-linked catechol-borate ester polymers are disclosed, along with methods of synthesizing and using such hydrogels. The hydrogels of the present invention are prepared by boronic acid-catechol complexation between catechol-containing macromonomers and boronic acid-containing cross-linkers. The resulting hydrogels are pH-responsive and self-healing, and can be used in a number of different biomedical applications, including in surgical implants, in surgical adhesives, and in drug delivery systems is data provides further evidence of the viability of using the disclosed hydrogels for in vivo in biomedical applications.
    Type: Application
    Filed: January 19, 2017
    Publication date: May 11, 2017
    Inventors: Phillip B. Messersmith, Lihong He, Dominic E. Fullenkamp
  • Patent number: 9636374
    Abstract: Polymeric delivery systems for boronic acid-containing therapeutics, related compounds and methods of use, for a pH-sensitive chemoselective approach to delivery of such a therapeutic.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: May 2, 2017
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Jing Su, Vincent L. Cryns
  • Patent number: 9637597
    Abstract: Methods of synthesizing a DOPA-melanin (DM) polymer are disclosed, as well as compositions comprising the DM polymer and uses thereof. The method comprises contacting a reactant such as 3,4-dihydroxyphenylalanine (DOPA) with a high concentration aqueous salt solution under oxidative conditions. The resulting DM polymer may form as insoluble particles or as a coating on a substrate surface. Exemplary uses for the DM polymers include removing heavy metal ions from contaminated solutions or capturing and delivering cationic drugs such as gentamicin.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: May 2, 2017
    Assignee: Northwestern University
    Inventors: Phillip B. Messersmith, Jinghao Kuang
  • Patent number: 9572910
    Abstract: Biocompatible hydrogels made from cross-linked catechol-borate ester polymers are disclosed, along with methods of synthesizing and using such hydrogels. The hydrogels of the present invention are prepared by boronic acid-catechol complexation between catechol-containing macromonomers and boronic acid-containing cross-linkers. The resulting hydrogels are pH-responsive and self-healing, and can be used in a number of different biomedical applications, including in surgical implants, in surgical adhesives, and in drug delivery systems is data provides further evidence of the viability of using the disclosed hydrogels for in vivo in biomedical applications.
    Type: Grant
    Filed: May 21, 2012
    Date of Patent: February 21, 2017
    Assignee: NORTHWESTERN UNIVERSITY
    Inventors: Phillip B. Messersmith, Lihong He, Dominic E. Fullenkamp