Patents by Inventor Phillip Buckhaults

Phillip Buckhaults has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detection of colorectal cancer
    Patent number: 8029764
    Abstract: Particular genes are aberrantly and consistently expressed in both adenomas and carcinomas of the colon. Products of such genes provide stool and serum markers for colorectal neoplasia. One particular tumor marker, Renal Dipeptidase (RDP), is expressed at high levels in tumors and at greatly reduced levels in normal tissues. The elevated expression of RDP occurs early and remains elevated during the neoplastic process. RDP may therefore be especially useful as a diagnostic tool for the early detection of colorectal neoplasia, even of presymptomatic colorectal neoplasia.
    Type: Grant
    Filed: September 9, 2002
    Date of Patent: October 4, 2011
    Assignee: The Johns Hopkins University
    Inventors: Phillip Buckhaults, Kenneth W. Kinzler, Bert Vogelstein
  • Design and synthesis of renal dipeptidase inhibitors
    Patent number: 7785564
    Abstract: Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: August 31, 2010
    Assignee: The Johns Hopkins University
    Inventors: Saeed R. Khan, Bert Vogelstein, Kenneth W. Kinzler, Hallur Gurulingappa, Phillip Buckhaults
  • Gene Mutation Profiling of CSMD1
    Publication number: 20090246789
    Abstract: A method for assessing risk of node-positive colorectal cancer in an individual is described. The method includes detecting mutations in CSMD1 genes in a tumor sample from the individual, the mutations being associated with increased risk of node-positive colorectal cancer.
    Type: Application
    Filed: March 25, 2009
    Publication date: October 1, 2009
    Applicant: University of South Carolina
    Inventors: Phillip Buckhaults, Christopher L. Farrell, Paul F. Meeh, Randal L. Croshaw
  • Design and synthesis of renal dipeptidase inhibitors
    Publication number: 20050271586
    Abstract: Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.
    Type: Application
    Filed: July 7, 2005
    Publication date: December 8, 2005
    Applicant: The Johns Hopkins University
    Inventors: Saeed Khan, Bert Vogelstein, Kenneth Kinzler, Hallur Gurulingappa, Phillip Buckhaults
  • Design and synthesis of renal dipeptidase inhibitors
    Patent number: 6927212
    Abstract: Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.
    Type: Grant
    Filed: July 28, 2003
    Date of Patent: August 9, 2005
    Assignee: The Johns Hopkins University
    Inventors: Saeed R. Khan, Bert Vogelstein, Kenneth W. Kinzler, Hallur Gurulingappa, Phillip Buckhaults
  • Secreted and cell surface genes expressed in benign and malignant colorectal tumors
    Publication number: 20040265824
    Abstract: Serial analysis of gene expression (SAGE) was used to identify transcripts encoding secreted or cell-surface proteins that were expressed in benign and malignant tumors of the colorectum. A total of 290,394 tags were analyzed from normal, adenomatous and cancerous colonic epithelium. Of the 21,343 different transcripts observed, 957 were found to be differentially expressed between normal and adenoma or between normal and cancer. Forty-nine transcripts were elevated ≧20-fold in adenomas, 40 transcripts were elevated ≧20-fold in cancers, and nine transcripts were elevated ≧20-fold in both. Product of six these nine transcripts (TGFBI, LYS, RDP, MIC-1, REGA, and DEHL) were predicted to be secreted or to reside on the cell surface and these were analyzed in more detail. The abnormal expression levels predicted by SAGE were confirmed by quantitative PCR analyses of each of these six genes.
    Type: Application
    Filed: August 23, 2004
    Publication date: December 30, 2004
    Inventors: Phillip Buckhaults, Kenneth W. Kinzler, Bert Vogelstein
  • Design and synthesis of renal dipeptidase inhibitors
    Publication number: 20040091422
    Abstract: Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity. These compounds can be used therapeutically and diagnostically for treatment and detection of tumors.
    Type: Application
    Filed: July 28, 2003
    Publication date: May 13, 2004
    Applicant: The Johns Hopkins University
    Inventors: Saeed R. Khan, Bert Vogelstein, Kenneth W. Kinzler, Hallur Gurulingappa, Phillip Buckhaults