Patents by Inventor Phillip Burwell

Phillip Burwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10376711
    Abstract: Light sources are incorporated into a guidewire for enabling the ability to render light therapy be added to catheters that do not have that capability. In one exemplary embodiment, a solid guidewire includes a conductive core, and light sources are added to compartments formed in a distal end of the guidewire. In another exemplary embodiment, a light source array is included in a distal end of a hollow guidewire. A plurality of openings are formed into the walls of the hollow guidewire surrounding the array, enabling light to pass through the openings. Conductors extend from the array though the hollow center of the guidewire, to a proximal end of the hollow guidewire. The hollow guidewire can be coated with a conductive material, so that the coating on the guidewire serves as a conductor.
    Type: Grant
    Filed: August 6, 2007
    Date of Patent: August 13, 2019
    Assignee: LIGHT SCIENCES ONCOLOGY INC.
    Inventors: Phillip Burwell, Zihong Guo, Jennifer K. Matson, Steven Ross Daly, David B. Shine, Gary Lichttenegger, Jean M. Bishop, Nick Yeo, Hugh Narciso
  • Publication number: 20160213945
    Abstract: A photoreactive agent and a drug therapy device including a support member configured to pass through a urethra having proximal and distal ends and a longitudinal internal lumen. A light generator carried by the support member, potted within the lumen, and positioned within the urethra to deliver light to the prostate. The light generator generates a light band with a peak at a preselected wavelength. A power source external to the support member powers the light generator. The positioning element locates the support member within the urethra. A transparent/translucent, integral window is positioned proximate to the prostate and allows light to pass through. The window extends 360 degrees radially from the support member. The light generator has at least LEDs or LOs having a dimension of approximately 0.3 mm×0.3 mm×0.1 mm (length×width×thickness).
    Type: Application
    Filed: April 5, 2016
    Publication date: July 28, 2016
    Applicant: PURDUE PHARMACEUTICAL PRODUCTS L.P.
    Inventors: Phillip Burwell, Zihong Guo, Jennifer K. Matson, Steven Ross Daly, David B. Shine, Gary Lichttenegger, Jean Bishop, Nick Yeo, Hugh Narciso, Llew Keltner, Jay Winship, Erik Hagstrom, Frank Zheng, James C. Chen, Joseph M. Hobbs
  • Patent number: 8685071
    Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: April 1, 2014
    Assignee: Purdue Pharmaceutical Products L.P.
    Inventors: Phillip Burwell, James C. Chen, Zihong Guo, Steven R. Daly, David B. Shine, Gary Lichttenegger, Jennifer K. Matson, Jean Bishop, Nick Yeo, Hugh Narciso
  • Publication number: 20120149986
    Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
    Type: Application
    Filed: February 21, 2012
    Publication date: June 14, 2012
    Applicant: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, James C. Chen, Zihong Guo, Steven R. Daly, David B. Shine, Gary Lichtlenegger, Jennifer K. Matson, Jean Bishop, Nick YEO, Hugh Narciso
  • Patent number: 8097028
    Abstract: The present invention provides a prophylactic light activated treatment method for subjects at risk of a plaque-mediated thrombotic event, such as acute coronary syndromes. In one embodiment, the subject receives a dose of photosensitizer sufficient to result in a concentration of photosensitizer in the neovascularization associated with atherosclerotic disease to permit effective photodynamic therapy. Light of a wavelength that excites the photosensitizer, but that does not to any significant extent penetrate to an adventitial layer of the blood vessel, is applied to the region of the blood vessel. The therapeutic light dose, which may be applied in sequential stages, is sufficient to cause closure of neovasculature leakage and lead to plaque stabilization and reduced adverse clinical outcomes. The present invention further provides light transmission devices and systems useful in carrying out the methods of the present invention.
    Type: Grant
    Filed: February 17, 2006
    Date of Patent: January 17, 2012
    Assignee: Light Sciences Oncology, Inc.
    Inventors: James C. Chen, Nicholas Yeo, Phillip Burwell, Thomas Wenger
  • Publication number: 20110077464
    Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 31, 2011
    Applicant: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, James C. Chen, Zihong Guo, Steven R. Daly, David B. Shine, Gary Lichttenegger, Jennifer K. Matson, Jean Bishop, Nick Yeo, Hugh Narciso
  • Publication number: 20100274330
    Abstract: Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
    Type: Application
    Filed: July 6, 2010
    Publication date: October 28, 2010
    Applicant: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, Zihong Guo, Jennifer K. Matson, Steven Ross Daly, David B. Shine, Gary Lichttenegger, Jean M. Bishop, Nick Yeo, Hugh Narciso, James C. Chen, William L. Barnard, Alexei N. Naimushin
  • Patent number: 7730894
    Abstract: Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: June 8, 2010
    Assignee: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, Zihong Guo, Jennifer Kristine Matson, Steven Ross Daly, David B. Shine, Gary Lichttenegger, Jean Bishop, Nick Yeo, Hugh Narciso
  • Publication number: 20080269846
    Abstract: Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source encompassed by another balloon. Yet another device is a catheter having two balloons and a sleeve extending there between. Within the sleeve, the catheter includes a light source and an expanding member.
    Type: Application
    Filed: April 10, 2008
    Publication date: October 30, 2008
    Applicant: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, Zihong Guo, Jennifer K. Matson, Steven Ross Daly, David B. Shine, Gary Lichttenegger, Jean M. Bishop, Nick Yeo, Hugh Narciso, James C. Chen, William L. Barnard, Alexei Naimushin
  • Publication number: 20080033519
    Abstract: Light sources are incorporated into a guidewire for enabling the ability to render light therapy be added to catheters that do not have that capability. In one exemplary embodiment, a solid guidewire includes a conductive core, and light sources are added to compartments formed in a distal end of the guidewire. In another exemplary embodiment, a light source array is included in a distal end of a hollow guidewire. A plurality of openings are formed into the walls of the hollow guidewire surrounding the array, enabling light to pass through the openings. Conductors extend from the array though the hollow center of the guidewire, to a proximal end of the hollow guidewire. The hollow guidewire can be coated with a conductive material, so that the coating on the guidewire serves as a conductor.
    Type: Application
    Filed: August 6, 2007
    Publication date: February 7, 2008
    Applicant: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, Zihong Guo, Jennifer Matson, Steven Daly, David Shine, Gary Lichttenegger, Jean Bishop, Nick Yeo, Hugh Narciso
  • Publication number: 20080027517
    Abstract: Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
    Type: Application
    Filed: July 5, 2007
    Publication date: January 31, 2008
    Applicant: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, Zihong Guo, Jennifer Matson, Steven Daly, David Shine, Gary Lichttenegger, Jean Bishop, Nick Yeo, Hugh Narciso
  • Patent number: 7252677
    Abstract: Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
    Type: Grant
    Filed: March 12, 2004
    Date of Patent: August 7, 2007
    Assignee: Light Sciences Oncology, Inc.
    Inventors: Phillip Burwell, Zihong Guo, Jennifer Kristine Matson, Steven Ross Daly, David B. Shine, Gary Lichttenegger, Jean Bishop, Nick Yeo, Hugh Narciso
  • Publication number: 20070142880
    Abstract: A light delivery apparatus to provide light treatment to a patient includes a catheter assembly having a light source that transmit light towards a target site within a patient. A balloon surrounds the light source and has a plurality of tissue engaging elements movable between first positions and second positions. In one embodiment, each element extends radially inward in the first position and radially outward in the second position. An insertion tool is used to deliver the light delivery apparatus. During use, the light delivery apparatus is rotationally locked with the insertion tool for improved steering, navigation, and aiming of emitted light.
    Type: Application
    Filed: November 7, 2006
    Publication date: June 21, 2007
    Inventors: William Barnard, Phillip Burwell, James Chen, Julene Christophersen, William Gembala, David Shine
  • Publication number: 20070129776
    Abstract: A light therapy system provides for self-alignment or positioning with respect to a joint of a subject. The light therapy system can provide light therapy to a body part of a subject. The therapy system has a main body configured to be placed adjacent a target site and an activatable light emitting system is coupled to the main body. The light emitting system is capable of delivering a therapeutic amount of light energy to the target site when the main body is placed adjacent the target site.
    Type: Application
    Filed: October 20, 2006
    Publication date: June 7, 2007
    Applicant: Light Sciences LLC
    Inventors: Anthony Robins, Phillip Burwell, David Shine, James Chen
  • Publication number: 20070038204
    Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
    Type: Application
    Filed: February 17, 2006
    Publication date: February 15, 2007
    Inventors: James Chen, Nicholas Yeo, Phillip Burwell, Thomas Wenger
  • Publication number: 20070002582
    Abstract: A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.
    Type: Application
    Filed: December 30, 2005
    Publication date: January 4, 2007
    Applicant: Light Sciences Corporation
    Inventors: Phillip Burwell, James Chen, Zihong Guo, Steven Daly, David Shine, Gary Lichttenegger, Jennifer Matson, Jean Bishop, Nick Yeo, Hugh Narciso
  • Publication number: 20050228260
    Abstract: Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.
    Type: Application
    Filed: March 12, 2004
    Publication date: October 13, 2005
    Inventors: Phillip Burwell, Zihong Guo, Jennifer Matson, Steven Daly, David Shine, Gary Lichttenegger, Jean Bishop, Nick Yeo, Hugh Narciso
  • Publication number: 20050128742
    Abstract: A light generating device for illuminating tissue adjacent to a body lumen while a distal end of the device is centered in the lumen, to render photodynamic therapy. The device can either occlude or displace bodily fluid, both without the use of a balloon. In one embodiment, a flushing lumen has a port adjacent to an array of light sources, to displace bodily fluid that might otherwise absorb light. Another embodiment employs a centering member that moves between a first position and a second position. The centering member centers the device in the lumen and preferably is formed of a shape memory material. In yet another embodiment, the device includes an outer sheath and an inner member that are independently positionable, enabling the centering member to be selectively positionable. The centering member can be non porous, such that the centering member also occludes fluid flow.
    Type: Application
    Filed: July 8, 2004
    Publication date: June 16, 2005
    Inventors: James Chen, Zihong Guo, Gary Lichttenegger, David Shine, Phillip Burwell
  • Publication number: 20050131510
    Abstract: Light generating devices for illuminating portions of vascular tissue to administer photodynamic therapy, and usable with, or including a distal protection device. A first device includes a hollow tip, a flushing lumen, a guidewire lumen, and at least one of a light source, and a hollow light transmissive shaft that is adapted to accommodate a light source. If desired, the device can include a balloon, so that a portion of a body lumen between the balloon and the distal protection device is isolated when the balloon is inflated. A second device includes inner and outer catheters, the outer catheter including a balloon, and the inner catheter including a light source and distal protection device comprising a shape memory polymer. Yet another device is a catheter having two balloons and a sleeve extending therebetween. Within the sleeve, the catheter includes a light source and an expanding member.
    Type: Application
    Filed: July 9, 2004
    Publication date: June 16, 2005
    Inventors: James Chen, David Shine, Gary Lichttenegger, Zihong Guo, Phillip Burwell, Steven Daly