Patents by Inventor Phillip C. C. Liu

Phillip C. C. Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS, METHODS AND KITS RELATING TO HER-2 CLEAVAGE
    Publication number: 20120263676
    Abstract: The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast cancer, by modulating the ADAM-mediated cleavage of Her-2. Further, the invention relates to compositions, methods and kits based on the surprising synergistic effect between inhibition of Her-2 cleavage by an ADAM and certain cytostatic (e.g., Herceptin) and cytotoxic (e.g., Taxol) compounds in, among other things, inhibiting tumor cell proliferation and inducing cell death. Additionally, the invention relates to novel variants of ADAM15, designated ADAM15 variant 1 and ADAM15 variant 2, now identified and isolated.
    Type: Application
    Filed: December 23, 2011
    Publication date: October 18, 2012
    Inventors: Steven M. Friedman, Peggy A. Scherle, Xiangdong Liu, Timothy C. Burn, Reid Huber, Phillip C.C. Liu, Gregory F. Hollis, Krishna Vaddi, Jordan S. Fridman
  • Compositions, methods and kits relating to Her-2 cleavage
    Patent number: 8088737
    Abstract: The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast cancer, by modulating the ADAM-mediated cleavage of Her-2. Further, the invention relates to compositions, methods and kits based on the surprising synergistic effect between inhibition of Her-2 cleavage by an ADAM and certain cytostatic (e.g., Herceptin) and cytotoxic (e.g., Taxol) compounds in, among other things, inhibiting tumor cell proliferation and inducing cell death. Additionally, the invention relates to novel variants of ADAM15, designated ADAM15 variant 1 and ADAM15 variant 2, now identified and isolated.
    Type: Grant
    Filed: April 2, 2004
    Date of Patent: January 3, 2012
    Assignee: Incyte Corporation
    Inventors: Steven M. Friedman, Peggy A. Scherle, Xiangdong Liu, Timothy C. Burn, Reid Huber, Phillip C. C. Liu, Gregory F. Hollis, Krishna Vaddi, Jordan S. Fridman
  • Compositions, methods and kits relating to Her-2 cleavage
    Publication number: 20040247602
    Abstract: The present invention relates to compositions, methods and kits based on the ADAM-mediated cleavage of Her-2. The present invention also relates to treatments for cancer, and in particular, breast cancer, by modulating the ADAM-mediated cleavage of Her-2. Further, the invention relates to compositions, methods and kits based on the surprising synergistic effect between inhibition of Her-2 cleavage by an ADAM and certain cytostatic (e.g., Herceptin) and cytotoxic (e.g., Taxol) compounds in, among other things, inhibiting tumor cell proliferation and inducing cell death. Additionally, the invention relates to novel variants of ADAM15, designated ADAM15 variant 1 and ADAM15 variant 2, now identified and isolated.
    Type: Application
    Filed: April 2, 2004
    Publication date: December 9, 2004
    Inventors: Steven M. Friedman, Peggy A. Scherle, Xiangdong Liu, Timothy C. Burn, Reid Huber, Phillip C.C. Liu, Gregory F. Hollis, Krishna Vaddi, Jordan S. Fridman
  • Yeast mammalian regulators of cell proliferation
    Patent number: 6383753
    Abstract: Novel, highly conserved cell cycle regulatory genes (Emg1 and ENIP1) are described along with methods employing Emg1 and ENIP1 to detect compounds that are agonistic or antagonistic to cell cycle progression.
    Type: Grant
    Filed: March 31, 2000
    Date of Patent: May 7, 2002
    Assignee: Regents of the University of Michigan
    Inventors: Dennis J. Thiele, Phillip C. C. Liu