Abstract: Provided herein are compositions and methods for the restoration of intracellular bioenergy in disorders characterized by intracellular bioenergetics imbalance. Specifically, compositions and methods provided herein include extracellular vesicles that include mitochondria and/or mitochondrial fragments.

Abstract: The present invention includes a method and apparatus providing an ongoing and real time indicator for prediction of health conditions during the usual lifetime of a person by providing an ongoing and real time indicator for predicting remaining lifetimes for one or more patients comprising: providing a monitoring system connected to the cloud, a Wi-Fi or Bluetooth network which is connected to a wearable device; and providing a wearable device which contains one or more accelerometers, temperature monitoring devices, EKG monitoring devices and other useful devices; wherein the wearable device is powered internally by a battery or other such appropriate energy sources.

Abstract: The methods of the invention exploit the capabilities of manganese-enhanced MRI (MEMRI), which provides viability-specific biological contrast agent through the intracellular accumulation of Mn2+. A typical contrast agent utilizes non-chelated Mn2+ in combination with Ca2+, e.g. as calcium gluconate. Active intracellular accumulation of Mn2+ generates high signal from the viable cells in normal tissue, or normal regions of heterogeneous tissue; no signal from the non-viable cells; and intermediate signal from viable but injured cells. The intermediate signal defines a “gray zone” of potentially salvageable cells.

Abstract: An insole includes a forefoot portion having a lower first recess; a cupped heel portion having a lower second recess; a mid-foot portion connecting together the forefoot portion and the heel portion, the mid-foot portion including a medial arch portion, and the forefoot, heel and mid-foot portions formed from a unitary resilient material; a plurality of protuberances in the second recess and having lower edges generally coplanar with a lower surface of the heel portion in surrounding relation to the second recess; a plurality of spaced apart spring walls formed from a viscoelastic gel in the first recess, the spring walls having lower edges generally coplanar with a lower surface of the forefoot portion which is in surrounding relation to the first recess; and a shell extending under the mid-foot portion and made of a resilient material that is stiffer than the unitary resilient material.

Abstract: An insole includes a forefoot portion having a lower first recess; a cupped heel portion having a lower second recess; a mid-foot portion connecting together the forefoot portion and the heel portion, the mid-foot portion including a medial arch portion, and the forefoot, heel and mid-foot portions formed from a unitary resilient material; a plurality of protuberances in the second recess and having lower edges generally coplanar with a lower surface of the heel portion in surrounding relation to the second recess; a plurality of spaced apart spring walls formed from a viscoelastic gel in the first recess, the spring walls having lower edges generally coplanar with a lower surface of the forefoot portion which is in surrounding relation to the first recess; and a shell extending under the mid-foot portion and made of a resilient material that is stiffer than the unitary resilient material.