Patents by Inventor Phillip Crews

Phillip Crews has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NOVEL COMPOUNDS RELATED TO MYCOTHIAZOLE AND METHODS OF TREATING CANCER
    Publication number: 20210221777
    Abstract: A pharmaceutically active mycathiozole analog or salt thereof is derived from naturally occurring mycathiozole. The analog or salt is useful in cancer treatment.
    Type: Application
    Filed: January 14, 2021
    Publication date: July 22, 2021
    Inventors: Tyler A. Johnson, Colon V. Cook, Nicole L. McIntosh, Joseph D. Morris, Frederick A. Valeriote, JiaJiu Shaw, Phillip Crews, Mani Maheshwari
  • Pyrroloquinolin compounds and methods of using same
    Patent number: 11020488
    Abstract: Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., pharmaceutical compositions, that include the pyrroloquinolin compounds and conjugates of the present disclosure are also provided. Further provided are therapeutic methods involving the administration of the pyrroloquinolin compounds, conjugates or compositions of the present disclosure. Kits that include the pyrroloquinolin compounds, conjugates or compositions are also provided.
    Type: Grant
    Filed: March 13, 2018
    Date of Patent: June 1, 2021
    Assignees: The Regents of the University of California, Henry Ford Health System
    Inventors: Phillip Crews, Frederick A. Valeriote, Sheng Lin, Erin P. McCauley, Nicholas Lorig-Roach, Karen Tenney
  • PYRROLOQUINOLIN COMPOUNDS AND METHODS OF USING SAME
    Publication number: 20200129631
    Abstract: Provided are pyrroloquinolin compounds of formula (1) or (II). In certain aspects, the pyrroloquinolin compounds are therapeutic, e.g., for treating a cell proliferative disorder. Also provided are conjugates that include the pyrroloquinolin compounds of the present disclosure. Compositions, e.g., pharmaceutical compositions, that include the pyrroloquinolin compounds and conjugates of the present disclosure are also provided. Further provided are therapeutic methods involving the administration of the pyrroloquinolin compounds, conjugates or compositions of the present disclosure. Kits that include the pyrroloquinolin compounds, conjugates or compositions are also provided.
    Type: Application
    Filed: March 13, 2018
    Publication date: April 30, 2020
    Inventors: Phillip Crews, Frederick A. Valeriote, Sheng Lin, Erin P. McCauley, Nicholas Lorig-Roach, Karen Tenney
  • (2-carboxamido)(3-Amino) thiophene compounds
    Patent number: 7696225
    Abstract: Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: April 13, 2010
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Jason Bloxham, Andrew Phillip Crew, Ayako Honda, An-Hu Li, Bijoy Panicker, Graham Michael Wynne, Lawrence Tardibono, Jr.
  • (2-carboxamido)(3-amino)thiophene compounds
    Patent number: 7524859
    Abstract: A method of treatment of hyperproliferative disorders comprises a step of administering an effective amount of a compound represented by
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: April 28, 2009
    Assignee: OSI Pharmaceuticals, Inc.
    Inventor: Andrew Phillip Crew
  • N-substituted benzimidazolyl c-Kit inhibitors
    Patent number: 7521448
    Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: April 21, 2009
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Joshua Bolger, Arlindo L. Castelhano, Andrew Phillip Crew, Han-Qing Dong, Ayako Honda, Radoslaw Laufer, An-Hu Li, Kristen Mulvihill, Li Qiu, Colin Peter Sambrook Smith, Yingchaun Sun, Graham Michael Wynne, Tao Zhang
  • N-Substituted Imidazopyridine c-Kit Inhibitors
    Publication number: 20090062275
    Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
    Type: Application
    Filed: September 12, 2008
    Publication date: March 5, 2009
    Inventors: Arlindo L. Castelhano, Andrew Phillip Crew, Han-Qing Dong, Radoslaw Laufer, An-Hu Li, Li Qiu, Colin Peter Sambrook Smith, Tao Zhang
  • N-substituted pyrazolyl-amidyl-benzimidazolyl c-Kit inhibitors
    Patent number: 7485658
    Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: February 3, 2009
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Joshua Bolger, Arlindo L. Castelhano, Andrew Phillip Crew, Radoslaw Laufer, An-Hu Li, Colin Peter Sambrook Smith, Yingchuan Sun
  • N3-substituted imidazopyridine c-Kit inhibitors
    Patent number: 7442709
    Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: October 28, 2008
    Assignee: OSI Pharmaceuticals, Inc.
    Inventors: Arlindo L. Castelhano, Andrew Phillip Crew, Han-Qing Dong, Radoslaw Laufer, An-Hu Li, Li Qiu, Colin Peter Sambrook Smith, Tao Zhang
  • (2-Carboxamido)(3-amino)thiophene compounds
    Patent number: 7101893
    Abstract: A method of treatment of hyperproliferative disorders comprises administering an effective amount of a compound represented by Formula II: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 27, 2005
    Date of Patent: September 5, 2006
    Assignee: OSI Pharmaceuticals, Inc.
    Inventor: Andrew Phillip Crew
  • (2-carboxamido)(3-amino)thiophene compounds
    Patent number: 6949563
    Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, wherein R1 is R2 is and R3 is C0-4alkyl, are useful in the treatment of cancer.
    Type: Grant
    Filed: January 6, 2004
    Date of Patent: September 27, 2005
    Inventors: Graham Michael Wynne, Kevin Doyle, Saleh Ahmed, An-Hu Li, John Fraser Keily, Chrystelle Marie Rasamison, Neil Anthony Pegg, Imaad Saba, Claire Thomas, Don Smyth, Shazia Sadiq, Gary Newton, Graham Dawson, Andrew Phillip Crew, Arlindo Lucas Castelhano
  • (2-carboxamido)(3-amino)thiophene compounds
    Publication number: 20040186124
    Abstract: Compounds represented by Formula (I): 1
    Type: Application
    Filed: January 6, 2004
    Publication date: September 23, 2004
    Inventors: Graham Michael Wynne, Kevin Doyle, Saleh Ahmed, An-Hu Li, John Fraser Keily, Chrystelle Marie Rasamison, Neil Anthony Pegg, Imaad Saba, Claire Thomas, Don Smyth, Shazia Sadiq, Gary Newton, Graham Dawson, Andrew Phillip Crew, Arlindo Lucas Castelhano
  • Sponge-derived terpenoids and methods of use
    Patent number: 6750247
    Abstract: Compounds that are effective lipoxygenase inhibitors, and methods and pharmaceutical compositions for inhibiting lipoxygenases and for treatment of lipoxygenase-mediated conditions in humans and other subjects. The compounds, methods and pharmaceutical compositions utilize subersic terpenoids, jaspic terpenoids, igernellic terpenoids, hippospongic terpenoids, halicondric terpenoids, dictyodendric terpenoids, and/or heteronemic terpenoids, and synthetic derivatives or analogs thereof. Exemplary compounds include (−)-subersic acid, (+)-subersin, jaspaquinol, (−)-jaspic acid, igernellin, halisufate 7, and hipposulfate C and D, and derivatives thereof.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: June 15, 2004
    Assignee: Galileo Laboratories, Inc.
    Inventors: Phillip Crews, Jennifer Carroll, Theodore Holman, Guy Miller, Steve Bobzin, Lesley Brown
  • Sponge-derived terpenoids and methods of use
    Publication number: 20030065025
    Abstract: Compounds that are effective lipoxygenase inhibitors, and methods and pharmaceutical compositions for inhibiting lipoxygenases and for treatment of lipoxygenase-mediated conditions in humans and other subjects. The compounds, methods and pharmaceutical compositions utilize subersic terpenoids, jaspic terpenoids, igernellic terpenoids, hippospongic terpenoids, halicondric terpenoids, dictyodendric terpenoids, and/or heteronemic terpenoids, and synthetic derivatives or analogs thereof. Exemplary compounds include (−)-subersic acid, (+)-subersin, jaspaquinol, (−)-jaspic acid, igernellin, halisufate 7, and hipposulfate C and D, and derivatives thereof.
    Type: Application
    Filed: May 31, 2002
    Publication date: April 3, 2003
    Inventors: Phillip Crews, Jennifer Carroll, Theodore Holman, Guy Miller, Steve Bobzin, Lesley Brown
  • Phenolic acid sulfate esters for prevention of marine biofouling
    Patent number: 5607741
    Abstract: p-Sulfoxy cinnamic acid isolated from methanolic extracts of the eelgrass Zostera marina having significant antifouling aquatic properties. p-Sulfoxy cinnamic acid was synthesized in the laboratory from p-coumaric acid, and antifouling activity was identical to the natural compound in laboratory bioassays. In addition, sulfate esters of other phenolic acids showed similar antifouling activity, suggesting that the sulfate ester was responsible for the antifouling effect.
    Type: Grant
    Filed: December 8, 1994
    Date of Patent: March 4, 1997
    Assignees: ARCH Development Corporation, The Regents of the University of California
    Inventors: Richard C. Zimmerman, Randall S. Alberte, James S. Todd, Phillip Crews
  • Phenolic acid sulfate esters for prevention of marine biofouling
    Patent number: 5384176
    Abstract: p-sulfoxy cinnamic acid isolated from methanolic extracts of the eelgrass Zostera marina having significant antifouling aquatic properties. p-sulfoxy cinnamic acid was synthesized in the laboratory from p-coumaric acid, and antifouling activity was identical to the natural compound in laboratory bioassays. In addition, sulfate esters of other phenolic acids showed similar antifouling activity, suggesting that the sulfate ester was responsible for the antifouling effect.
    Type: Grant
    Filed: December 11, 1992
    Date of Patent: January 24, 1995
    Inventors: Richard C. Zimmerman, Randall S. Alberte, James S. Todd, Phillip Crews
  • Alkaloids of marine origin
    Patent number: 4959370
    Abstract: This invention is directed to novel compounds of Formula (I): ##STR1## wherein R is hydrogen or methyl, or a pharmaceutically acceptable salt thereof and pharmaceutical compositions formulated therewith. This invention is also directed to a method for treating helminthiasis and for inhibiting reverse transcriptase activity in an animal by the administration of compounds of Formula (I).
    Type: Grant
    Filed: March 29, 1989
    Date of Patent: September 25, 1990
    Inventors: Phillip Crews, Thomas R. Matthews, Wayne D. Inman
  • Anthelmintic dysinins of marine origin
    Patent number: 4943589
    Abstract: This invention is directed to a method for treating helminthiasis which comprises administering to an animal in need thereof an anthelmintically effective amount of a compound of Formula (I): ##STR1## where R.sup.1 is hydrogen or --SR.sup.2,whereinR.sup.2 is hydrogen, --C(O)--CH.sub.3, or ##STR2## or a pharmaceutically acceptable salt thereof. This invention is also directed to a composition for treating helminthiasis in an animal which comprises a pharmaceutically acceptable excipient and an anthelmintically effective amount of a compound of Formula (I). This invention is also directed to novel compounds of Formula (I) wherein R.sup.
    Type: Grant
    Filed: October 27, 1988
    Date of Patent: July 24, 1990
    Assignees: Syntex (U.S.A.) Inc., The Regents of the Univ. of California
    Inventors: Phillip Crews, Thomas R. Matthews, Paul Horton