Patents by Inventor Phillip D. Cook

Phillip D. Cook has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing diaminopyrimido(4,5-d)pyrimidine glycoside and glycotide
    Patent number: 4801698
    Abstract: The aminoglycoside and aminoglycotide N.sup.4 -(2,3,5-tri-O-acetyl-.beta.-D-ribofuranosyl)pyrimido[4,5-d]pyrimidine-4,8- diamine and N.sup.4 -(5-O-phosphono-.beta.-D-ribofuranosyl-pyrimido[4,5-d]pyrimidine-4,8-diami ne exhibit antiviral activity as well as cytotoxic activity against the L1210 and mammary 16/C tumor cell lines.An improved method for their production involves the production of a sylilated intermediate and reaction of the intermediate with tetra-O-acetyl-.beta.-D-ribofuranose in the presence of the specific catalyst trimethylsilyltrifluoromethanesulfonate.
    Type: Grant
    Filed: August 15, 1986
    Date of Patent: January 31, 1989
    Assignee: Warner-Lambert Company
    Inventors: Phillip D. Cook, David A. Berry
  • Compound 2-iodo-2'-deoxyadenosine
    Patent number: 4719295
    Abstract: Nucleotide and nucleoside compounds are provided, namely 2-halo-2'-deoxyadenosine 5'-phosphate compounds (I) especially as the monosodium and disodium salt, and 2-iodo-2'-deoxyadenosine (II); as well as a method for their production, pharmaceutical compositions comprising the compounds, and methods of treatment using the compounds in dosage form. The compounds of the invention have pharmacological properties and are useful antimicrobial agents, antiviral agents, and antileukemic agents.
    Type: Grant
    Filed: June 27, 1986
    Date of Patent: January 12, 1988
    Assignee: Warner-Lambert Company
    Inventors: Phillip D. Cook, Roland K. Robins, Dennis J. McNamara
  • 4-amino-3-halo-2-pyridinone nucleoside and nucleotide compounds
    Patent number: 4681873
    Abstract: 4-Amino-3-halo-1-.beta.-D-ribofuranosyl-2-(1H)-pyridinone, 4-amino-3-halo-1-(2-deoxy-.beta.-D-pentofuranosyl)-2(1H)-pyridinone, and nucleosides and 4-amino-3-halo-1-(2-deoxy-2,2-difluoro.beta.-D-pentofuranosyl)-2(1H)-pyrid inone nucleosides and nucleotides are useful as antiviral agents and possess in vivo activity against the L1210 murine leukemia cell line.
    Type: Grant
    Filed: July 29, 1985
    Date of Patent: July 21, 1987
    Assignee: Warner-Lambert Company
    Inventors: Dennis J. McNamara, Phillip D. Cook
  • Process for producing 4-carbamoyl-1H-imidazolium-5-olate
    Patent number: 4503235
    Abstract: A process is provided for producing 4-carbamoyl-1H-imidazolium-5-olate (I) ##STR1## by reacting aminomalonamide H.sub.2 N--CH(CONH.sub.2).sub.2 and formamidine CH(.dbd.NH)NH.sub.2 compound in a liquid medium comprising alcohol under conditions such that the product I can be obtained in a solid form that is directly recoverable from the medium, free of aminomalonamide and recrystallizable.
    Type: Grant
    Filed: March 11, 1983
    Date of Patent: March 5, 1985
    Assignee: Warner-Lambert Company
    Inventors: Phillip D. Cook, Dennis J. McNamara