Patents by Inventor Phillip Gibbs
Phillip Gibbs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230407369Abstract: Disclosed is a kit including an oral wash composition and post collection stabilization solution for collection of analyte in oral fluid sample. The oral wash optionally includes an internal tracer, agents to induce salivation, maintain oral wash integrity at room temperature, and stabilize the collected oral fluid, and one or more dyes. The post collection stabilization solution includes agents which maintain collected analyte integrity at room temperature. The oral wash is used to collect saliva from the oral cavity, to determine the presence of an analyte in the saliva. The method includes rinsing the oral cavity with the oral wash for a period of time effective to stimulate saliva production, collecting the resulting fluid, contacting the resulting fluid with the post collection stabilization solution and subjecting the resulting fluid to a suitable analytical method to detect the presence of analyte in the sample.Type: ApplicationFiled: September 29, 2021Publication date: December 21, 2023Inventor: Phillip Gibbs
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Publication number: 20220276234Abstract: Point-of-care assays for quantitatively measuring the amount of small analytes, such as opioids, tetrahydrocannabinol (“THC”), or hormones, in a biological sample are disclosed. The assays are capable of non-competitive detection of a small analyte using binding agents that selectively bind the analyte and capture agents that selectively bind a complex of the binding agent and analyte but do not bind either free binding agent or free analyte. The assay is capable of simultaneous diction of multiple analytes for multiplex analysis and quantitative control. Quantitative measurements are obtained by plotting results against a response surface calculated from a plurality of analyte standards and adjusted using internal controls.Type: ApplicationFiled: May 9, 2022Publication date: September 1, 2022Inventor: Phillip Gibbs
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Publication number: 20220003741Abstract: Disclosed are oral wash compositions for collection of analyte in oral fluid sample. The oral wash includes an internal tracer, which can be directly detected by a mass-spec-based analytical method such as LC-MS, GC-MS, CE-MS, HPLC-MS/MS, HPLC-TOF or MALDI-TOF assay, along with all the other analytes being tested in the collected oral fluid. The oral wash optionally includes agents to induce salivation, maintain oral wash integrity at room temperature, and stabilize the collected oral fluid, and one or more dyes. The oral wash is used to collect saliva from the oral cavity, in order to determine the presence of an analyte in the saliva. The method includes rinsing the oral cavity with the oral wash for a period of time effective to stimulate saliva production, collecting the resulting fluid and subjecting the resulting fluid to a mass-spec-based analytical method to detect the presence of an analyte in the sample.Type: ApplicationFiled: November 18, 2019Publication date: January 6, 2022Inventor: Phillip Gibbs
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Publication number: 20190204309Abstract: Point-of-care assays for quantitatively measuring the amount of small analytes, such as opioids, tetrahydrocannibinol (“THC”), or hormones, in a biological sample are disclosed. The assays are capable of non-competitive detection of a small analyte using binding agents that selectively bind the analyte and capture agents that selectively bind a complex of the binding agent and analyte but do not bind either free binding agent or free analyte. The assay is capable of simultaneous diction of multiple analytes for multiplex analysis and quantitative control. Quantitative measurements are obtained by plotting results against a response surface calculated from a plurality of analyte standards and adjusted using internal controls.Type: ApplicationFiled: December 20, 2018Publication date: July 4, 2019Inventor: Phillip Gibbs
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Publication number: 20070250175Abstract: A trial system for a prosthesis is described. The prosthesis can include an acetabular prosthesis generally for implantation in an acetabulum and the surrounding pelvis. The acetabular prosthesis includes an acetabular cup having a substantially concave inner surface and a substantially convex outer surface. One trial shell or a collection of trial shells are provided to trial a range of motion of the hip joint before implanting a shell prosthesis into the acetabular prosthesis.Type: ApplicationFiled: June 26, 2007Publication date: October 25, 2007Applicant: BIOMET MANUFACTURING CORP.Inventors: Jason Meridew, Phillip Gibbs
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Patent number: 7163815Abstract: The present invention is directed to compositions and methods comprising NAD(P)H oxidases, particularly bacterial oxidases, nucleic acids, recombinant plasmid vectors and recombinant proteins therein encoded, and host cells comprising the oxidases and nucleic acids. The present invention also comprises an isolated bacterial oxidase that oxidizes both NADH and NADPH. Methods for producing the enzymes and enzymatic reactions comprising use of NAD(P)H oxidases and products of such reactions are also disclosed.Type: GrantFiled: January 28, 2005Date of Patent: January 16, 2007Assignee: Georgia Tech Research CorporationInventors: Bettina Riebel-Bommarius, Andreas Bommarius, Phillip Gibbs, William Wellborn
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Publication number: 20070008530Abstract: Relating to chiral detection systems, various improvements are disclosed including an improved apparatus for detecting a chiral property of a sample. It has a rugged and stable optical rail that operates as a heat sink to the systems' elements and comprises a captive guide structure of heat conductive material having an elevated top platform and a dove tailed lip on the sides. The elevated top platform has a substantial width in comparison to a height of the elevated top platform. The apparatus further includes a wide base portion of heat conductive material supportive of the captive guide structure. The base has a width that is at least twice the width of the elevated top platform and a substantial thickness relative to the captive guide structure.Type: ApplicationFiled: June 21, 2006Publication date: January 11, 2007Inventors: Phillip Gibbs, John Wade
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Publication number: 20060217815Abstract: A constraining prosthesis to reduce the possibility of a dislocation of the prosthesis after implantation is taught. A constraining liner is taught to include a constraining passage smaller than an internal diameter of the liner. A head can include a portion that is small enough to be positioned into the liner. The head can include a second dimension that is greater than the opening to constrain the modular head within the liner. A kit is also taught for trialing prosthesis to provide and determine a customized and personal fit of the prosthesis for each patient.Type: ApplicationFiled: May 31, 2006Publication date: September 28, 2006Applicant: Biomet Manufacturing CorpInventors: Phillip Gibbs, W. Slone, Troy Hershberger, Kim Parcher
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Publication number: 20060009857Abstract: A method for producing a prosthetic having metal articulating surfaces is disclosed. The method includes impinging at least a portion of the articulating surface with high energy laser electromagnetic radiation, to form a lasershot peened surface. A hardened portion of the surface is then post-processed to form a layer having a predetermined finish.Type: ApplicationFiled: July 8, 2004Publication date: January 12, 2006Inventors: Phillip Gibbs, David Schroeder, Ryan Lakin
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Publication number: 20060001876Abstract: An apparatus and method for improved detection of a chiral property of a sample begins with a probe beam of light having a first modulation frequency ? and is further modulated with a second modulation frequency ?. A non-linear photo-detector, which may include multiple detector portions to form a balanced receiver, mixes the first modulation with the second modulation to analyze frequency components at inter-modulated sidebands, where the level of the inter-modulated sidebands are related to the chiroptical property of the sample. The inter-modulated sidebands may be the additive sidebands or the subtractive sidebands. A lock-in detector can be used to receive a signal output from the non-linear photo-detector and generate the modulation signals at the different modulating frequencies. Furthermore, the non-linear photo-detector may analyze a ratio of the inter-modulated sideband levels, such as (?+2?)/(?+?), to yield a signal that is linearly related to the chiral property of the sample.Type: ApplicationFiled: June 29, 2005Publication date: January 5, 2006Inventors: Phillip Gibbs, Jason Beebe
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Publication number: 20060001509Abstract: An apparatus and method for automatically tuning a resonant circuit in a chiroptical measurement system. A sample cell holds a sample being measured for a chiroptical property as the sample is modulated by the resonant circuit. A signal source coupled to the resonant circuit generates a driving signal at one of a plurality of frequencies to modulate the resonant circuit. The frequencies are within a range of expected resonant frequencies for the resonant circuit. A feedback loop circuit coupled to the signal source is used to adjust the frequency of the driving signal to another of the frequencies in response to a feedback signal associated with a measured parameter of the driving signal. In this way, the frequency of the driving signal is adjusted to create a resonant condition. The driving signal may also be applied at a reduced power level so that the resonant circuit can be driven at off-resonant frequencies within the range of frequencies.Type: ApplicationFiled: June 29, 2005Publication date: January 5, 2006Inventor: Phillip Gibbs
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Publication number: 20050250465Abstract: The present invention provides a method, circuit and system for phase-sensitive detection and recovery of complex signals of interest using a double reference lock-in detector. A double reference lock-in detector may have two or more reference signal sources whose signals are first combined, producing a composite (e.g., inter-modulation) reference signal. This signal is then mixed with an input signal, yielding the desired selectivity at the frequency(ies) of interest. A second embodiment uses external reference signals, synchronizing internal references to these before combining the reference signals. Such detectors may used in chiral detection systems for recovering predetermined signals of interest associated with chiral properties of a sample being tested.Type: ApplicationFiled: May 3, 2005Publication date: November 10, 2005Inventor: Phillip Gibbs
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Publication number: 20050196788Abstract: The present invention is directed to compositions and methods comprising NAD(P)H oxidases, particularly bacterial oxidases, nucleic acids, recombinant plasmid vectors and recombinant proteins therein encoded, and host cells comprising the oxidases and nucleic acids. The present invention also comprises an isolated bacterial oxidase that oxidizes both NADH and NADPH. Methods for producing the enzymes and enzymatic reactions comprising use of NAD(P)H oxidases and products of such reactions are also disclosed.Type: ApplicationFiled: January 28, 2005Publication date: September 8, 2005Applicant: Georgia Tech Research CorporationInventors: Bettina Renate Else Bommarius, Andreas Bommarius, Phillip Gibbs, William Wellborn
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Publication number: 20050128482Abstract: A differential method has been developed which determines displacement from the midpoint of optical transmission (±45°) and utilizes the coupled nature of the two signals for common mode noise rejection to enhance the detection of chiral species. A beam of light is modulated, applied to the chiral mixture, and then split into a first beam and a related orthogonal beam by a polarizer or prism. The first beam and orthogonal beam are converted into electrical signals before a differential comparison of the signals is performed to detect a desired chiral species within the chiral mixture.Type: ApplicationFiled: November 24, 2004Publication date: June 16, 2005Inventor: Phillip Gibbs
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Publication number: 20050094144Abstract: A new generation polarimetry apparatus and methodology is disclosed, which involve passing polarized light through a sample including a chiral analyte, where the analyte is under the influence of a periodically varying magnetic field. The apparatus also utilizes optical heterodyne detection and lock-in detection at higher order harmonics of the magnetic field modulation frequency to improve sensitivity and detection limits of optical properties of chiral analytes.Type: ApplicationFiled: October 1, 2002Publication date: May 5, 2005Inventors: Phillip Gibbs, Rick rebino, Andreas ommarius, Mark Kimmel
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Publication number: 20050021148Abstract: A trial system for an acetabular prosthesis is described. The acetabular prosthesis is generally for implantation in an acetabulum and surrounding pelvis. The acetabular prosthesis includes an acetabular cup having a substantially concave inner surface and a substantially convex outer surface. The described acetabular prosthesis is especially useful in revision hip implant procedures where significant bone tissue loss has occurred either in or around the acetabulum and/or the pelvis. A collection of trial shells are provided to trial a range of motion of the hip joint before implanting a prosthetic shell into the acetabular prosthesis.Type: ApplicationFiled: November 3, 2003Publication date: January 27, 2005Inventor: Phillip Gibbs