Abstract: A system is provided comprising a robotic instrument for use with a tool. In some versions, the robotic instrument comprises a hand-held portion to be held by a user and a tool support movably coupled to the hand-held portion to support the tool. The robotic instrument further includes an actuator assembly operatively attached to the tool support and the hand-held portion and configured to move the tool support relative to the hand-held portion in a plurality of degrees of freedom. The robotic instrument may includes a handle alignment member extending from the hand-held portion. At least a portion of the handle alignment member and a tool plane defined by the tool are aligned when the tool support has an optimal range of motion relative to the hand-held portion.

Abstract: An oral product includes a body that is wholly receivable in an oral cavity. The body includes a mouth-soluble polymer matrix, cellulosic fibers embedded in the mouth-soluble polymer matrix, and nicotine or a derivative thereof dispersed in the mouth-soluble polymer matrix. The oral product is adapted to release the nicotine or a derivative thereof from the body when the body is received within the oral cavity and exposed to saliva.

Abstract: A system and method including receiving a digital representation of a road that includes one or more lane representations; defining a factor graph including variable nodes and constraint nodes that encode lane boundary constraints for the lane map; translating the factor graph into a nonlinear optimization problem for altitudes of the lane map; generating a solution to the optimization problem; and generating a corrected lane map with an optimized altitude for the road based on the generated solution.

Abstract: Disclosed are various examples for an application settings module that provides uniform access to diverse types of data, such as mobile device settings. A client device, such as a mobile device, can be configured through execution of program instructions to access a schema file comprising a definition of a plurality of keypaths, where individual ones of the plurality of keypaths uniquely correspond to one of a plurality of device settings and the keypaths are defined in the schema file in association with a plurality of methods. The client device can identify a function invoked using one of the keypaths to read or write a corresponding one of the device settings, whether stored locally or remote, and, in response to the function being invoked, execute a portion of the methods corresponding to the one of the keypaths in the schema file and return a result to a requesting process.

Abstract: In embodiments of the present invention improved capabilities are described for modifying the display of a workflow component from including a depiction of a first representation level to a depiction of a second representation level, wherein one of the depiction at the first representation level and the depiction at the second representation level includes a depiction of the functionality associated with the workflow component and the other of the depiction at the first representation level and the depiction at the second representation level includes a view of programming code for providing the functionality associated with the workflow component.

Abstract: In embodiments of the present invention improved capabilities are described for modifying the display of a workflow component from including a depiction of a first representation level to a depiction of a second representation level, wherein one of the depiction at the first representation level and the depiction at the second representation level includes a depiction of the functionality associated with the workflow component and the other of the depiction at the first representation level and the depiction at the second representation level includes a view of programming code for providing the functionality associated with the workflow component.

Abstract: A head positioning device for athletic training is provided. The device includes an elongated rigid rod with a hand grip attached on one end and a flexible joint attached to the other end to allow for rotational pivoting motion. A head gripping apparatus is attached to the flexible joint and allows a coach or trainer to guide the head position of an athlete learning proper head positioning for a particular athletic activity. The device is unique in that it incorporates active feedback from a coach or trainer to an athlete regarding proper head positioning.

Abstract: Provided herein are methods for identifying and isolating polynucleotides coding for polypeptides having D-allulose 3-epimerase activity from a wide variety of microorganisms. Also provided are nucleic acid constructs, vectors and recombinant host cells comprising the polynucleotides coding for D-allulose 3-epimerase activity as well as methods for producing allulose from fructose using said recombinant host cells having D-allulose 3-epimerase activity or the D-allulose 3-epimerase enzyme of said recombinant host cells having D-allulose 3-epimerase activity.

Abstract: Provided are systems and methods for detecting a vehicle with sensors that are not calibrated properly and calibrating such sensor in real-time. In one example, a method may include iteratively capturing sensor data of a road while the vehicle is travelling on the road;, monitoring a calibration of the sensors of the vehicle based on the sensor data, determining that the sensors of the vehicle are not calibrated properly based on the monitoring, generating a calibration target of an object on the road based on the sensor data, and adjusting a calibration parameter of the one or more sensors of the vehicle based on the generated calibration target.

Abstract: A rigid stopper (10) made of bisphenol-free polycarbonate and silicone synthetic materials, particularly for a wine bottle (48), comprises a cylindrical body (12) and two opposing faces (16, 18), and at least two compressible-elastomeric “O”-rings (22, 24) seated in corresponding circumferential grooves (26, 28) on a side (14) of the body (12). The faces (16, 18) are comprised of foramen (42, 44) respectively which communicate with a volute-cavity (40) for the purpose of accepting a cork-screw-extractor. The volute-cavity (40) is comprised of a partition (46) at a central-plane (56) for the purpose of preventing wine from leaking through the volute-cavity (40). “O”-rings (22, 24) are compressively forced into a mouth (50) of a bottle (48) positioning either face (16) or face (18) flush with the mouth (50) thereby providing adequate compressive force in maintaining position of the stopper (10).

Abstract: The present disclosure describes, in part, compositions and methods for the treatment of NASH and NASH-associated diseases. Compositions comprising an agent able to increases the expression, activity, or level of one more of a protective miRNA, preferably miR-375 are provided that may be used for the treatment of liver and/or liver-associated disease is treated in the subject.

Abstract: A recreational pack configured to hold a pair of skis or similar elongate recreational device on the back of a user. The pack includes a pouch configured to secure a portion of a pair of skis within the pouch. In this regard, the pouch includes an upper edge comprising a cinching mechanism that is configured to be opened and closed to permit access to an interior volume of the pouch, and a slit operatively disposed through a lower edge of the pouch and configured to receive a pair of skis or similar equipment within and through the slit. The pack secures the skis in a useful and efficient manner and advantageously may be folded and placed in a user’s pocket when not in use.

Abstract: Provided are systems and methods for detecting a vehicle with sensors that are not calibrated properly and calibrating such sensor in real-time. In one example, a method may include iteratively capturing sensor data of a road while the vehicle is travelling on the road; monitoring a calibration of the sensors of the vehicle based on the sensor data, determining that the sensors of the vehicle are not calibrated properly based on the monitoring, generating a calibration target of an object on the road based on the sensor data, and adjusting a calibration parameter of the one or more sensors of the vehicle based on the generated calibration target.

Abstract: A system and method including receiving a digital representation of a road that includes one or more lane representations; defining a factor graph including variable nodes and constraint nodes that encode lane boundary constraints for the lane map; translating the factor graph into a nonlinear optimization problem for altitudes of the lane map; generating a solution to the optimization problem; and generating a corrected lane map with an optimized altitude for the road based on the generated solution.

Abstract: Provided are systems and methods for detecting a vehicle with sensors that are not calibrated properly and calibrating such sensor in real-time. In one example, a method may include iteratively capturing sensor data of a road while the vehicle is travelling on the road; monitoring a calibration of the sensors of the vehicle based on the sensor data, determining that the sensors of the vehicle are not calibrated properly based on the monitoring, generating a calibration target of an object on the road based on the sensor data, and adjusting a calibration parameter of the one or more sensors of the vehicle based on the generated calibration target.

Abstract: A rigid stopper (10) made of synthetic materials, particularly for wine bottles, comprises a substantially cylindrical body (12) defining a longitudinal axis (20), with a side surface (14) and two opposing substantially flat end faces (16, 18), and at least two compressible-elastomeric “O”-rings (22, 24) seated in corresponding semicircular-circumferential-grooves (26, 28) on the side surface (14). The semicircular-circumferential-grooves (26, 28) are positioned symmetrically about a central-plane (56) toward faces (16, 18) of body (12) respectively. Faces (16, 18) are comprised of foramen (42, 44) respectively which communicate with a volute cavity (14) for the purpose of accepting a typical cork-screw-extractor.

Abstract: A combination snake catching and killing device is provided. The device includes an elongated hollow body configured to house a blade assembly with a blade used for dismembering a snake when fired. A handle assembly includes a handle, a charge handle configured to cock and fire the blade, and a grip lever configured to activate a gripping member with jaws that can grip a snake allowing a user to handle and/or relocate a snake or kill the snake, as necessary.

Abstract: A method of simulating an emergency response training scenario to users in different locations, including customizing a scenario, initiating a game state having a threat level and a time remaining, assigning a role to each of a plurality of users wherein each of the users uses a device, assigning digital assets within the scenario to each of the users, displaying an introduction sequence, initiating an incident and simultaneously notifying a first group of at least two users, logging and scoring a chosen response from the possible responses compared to a scoring system, updating the game state whereby the threat level is raised or lowered and the time remaining is increased or decreased, triggering another event to at least two of the plurality of users, and communicating a score calculated in the logging and scoring step to at least one user on one of the at least one client device.

Abstract: A system, apparatus, and method for policy management is provided. The system, apparatus, and method provide a universal policy management solution to unify multiple bespoke systems to enable management of access and other policies in distributed and/or heterogeneous environments. The system, apparatus, and method uses or may be referred to as Identity Query Language or “IDQL.” Policies and user access are defined centrally, and these policies are distributed out to the various bespoke systems. This distribution is aided by a policy gateway, or orchestrator, which acts as a policy mapper and/or API wrapper which accepts IDQL policy configurations, maps them to an imperative identity system, and carries out the IDQL command in the identity systems' native API calls.

Abstract: In embodiments of the present invention improved capabilities are described for modifying the display of a workflow component from including a depiction of a first representation level to a depiction of a second representation level, wherein one of the depiction at the first representation level and the depiction at the second representation level includes a depiction of the functionality associated with the workflow component and the other of the depiction at the first representation level and the depiction at the second representation level includes a view of programming code for providing the functionality associated with the workflow component.