Abstract: The present invention relates to natural aqueous essence compositions comprised of flavor and aroma constituents from hops. The invention also relates to methods for adding flavor and aroma to beers, ciders, meads, or other fermented beverages, as well as other alcoholic and non-alcoholic beverages such as seltzers, flavored waters, and teas where a hop-derived flavor and aroma is desired. The aqueous essence compositions are comprised of compounds that are naturally present in hops or in beer and/or result from processes that occur during brewing or in the aqueous processing of hop cones, hop pellets, or other solids separated from the hop plant (Humulus lupulus). The present invention also relates to the process by which aroma and flavor components are released and isolated from hops in a process that involves steam stripping, concentration, and collection of valuable aroma- and flavor-active hop constituents.

Abstract: This invention relates to IL-12 Fc fusion proteins and their use in medicine, pharmaceutical compositions comprising the same, and methods of using the same as agents for treatment and/or prevention of cancer.

Abstract: The present invention relates to natural aqueous essence compositions comprised of flavor and aroma constituents from hops. The invention also relates to methods for adding flavor and aroma to beers, ciders, meads, or other fermented beverages, as well as other alcoholic and non-alcoholic beverages such as seltzers, flavored waters, and teas where a hop-derived flavor and aroma is desired. The aqueous essence compositions are comprised of compounds that are naturally present in hops or in beer and/or result from processes that occur during brewing or in the aqueous processing of hop cones, hop pellets, or other solids separated from the hop plant (Humulus lupulus). The present invention also relates to the process by which aroma and flavor components are released and isolated from hops in a process that involves steam stripping, concentration, and collection of valuable aroma- and flavor-active hop constituents.

Abstract: Provided herein is a method of forming a ventricular support device for a diseased heart, including providing imaging data of the diseased heart, forming a three-dimensional (3D) heart model based on the imaging data, providing strain data including a plurality of strain estimates for at least one segment of the diseased heart, mapping the plurality of strain estimates onto corresponding portions of the 3D heart model to form a 3D diseased heart model, based on the 3D diseased heart model, forming a model of the ventricular support device configured to surround at least a portion of the diseased heart and provide support based upon said strain estimates, and converting the model of the ventricular support device to a digital file useful for directing a 3D printer device to print said ventricular support device for said diseased heart. Also provided is a customized ventricular support device so produced.

Abstract: The present invention relates to natural aqueous essence compositions comprised of flavor and aroma constituents from hops. The invention also relates to methods for adding flavor and aroma to beers, ciders, meads, or other fermented beverages, as well as other alcoholic and non-alcoholic beverages such as seltzers, flavored waters, and teas where a hop-derived flavor and aroma is desired. The aqueous essence compositions are comprised of compounds that are naturally present in hops or in beer and/or result from processes that occur during brewing or in the aqueous processing of hop cones, hop pellets, or other solids separated from the hop plant (Humulus lupulus). The present invention also relates to the process by which aroma and flavor components are released and isolated from hops in a process that involves steam stripping, concentration, and collection of valuable aroma- and flavor-active hop constituents.

Abstract: The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative metastatic breast tumor cells. Information on the expression and/or activation levels of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

Abstract: A golf swing training aid includes a golf club having a shaft and a club head. The club head has a hollow compartment for capturing a golf ball and is defined by a top wall, an opposing bottom wall, and a real wall. The club head has an open front face that forms an entrance into the hollow compartment. The club head has a slot formed within the bottom wall and being open along the front face of the club head for receiving a golf tee as the club head contacts the golf ball. An internal movable part is provided within the hollow compartment and moves between a raised position which allows the golf ball to travel to a rear ball capture space within the hollow compartment and a lowered position which is configured for capturing the golf ball within rear ball capture space located between the rear wall and the internal movable part.

Abstract: The present invention provides methods for selecting a suitable anticancer drug for the treatment of patient with non-small cell lung cancer (NSCLC). The present invention also provides methods for determining drug resistance in NSCLC patients receiving EGFR inhibitor therapy.

Abstract: An edgelit recessed luminaire includes a housing that defines an inner cavity and has a pair of side panels. Each side panel includes one or more torsion spring receivers. Further, the edgelit recessed luminaire includes a light engine that includes torsion springs that are pivotally coupled to the light engine via torsion spring brackets. The light engine is removably coupled to the housing such that in an open position, the light engine is suspended from the housing via the torsion springs providing access to the inner cavity and in a closed position, the light engine covers the inner cavity of the housing. Alternatively, a linear light module is removably coupled to the housing.

Abstract: Provided herein is a method of forming a ventricular support device for a diseased heart, including providing imaging data of the diseased heart, forming a three-dimensional (3D) heart model based on the imaging data, providing strain data including a plurality of strain estimates for at least one segment of the diseased heart, mapping the plurality of strain estimates onto corresponding portions of the 3D heart model to form a 3D diseased heart model, based on the 3D diseased heart model, forming a model of the ventricular support device configured to surround at least a portion of the diseased heart and provide support based upon said strain estimates, and converting the model of the ventricular support device to a digital file useful for directing a 3D printer device to print said ventricular support device for said diseased heart. Also provided is a customized ventricular support device so produced.

Abstract: The present invention provides antibody-based arrays for detecting the activation state and/or total amount of a plurality of signal transduction molecules in rare circulating cells and methods of use thereof for facilitating cancer prognosis and diagnosis and the design of personalized, targeted therapies.

Abstract: The present invention provides methods for selecting a suitable anticancer therapy, and for identifying and predicting response for the treatment of a gastric cancer.

Abstract: A golf swing training aid includes a golf club having a shaft and a club head. The club head has a hollow compartment for capturing a golf ball and is defined by a top wall, an opposing bottom wall, and a real wall. The club head has an open front face that forms an entrance into the hollow compartment. The club head has a slot formed within the bottom wall and being open along the front face of the club head for receiving a golf tee as the club head contacts the golf ball. An internal movable part is provided within the hollow compartment and moves between a raised position which allows the golf ball to travel to a rear ball capture space within the hollow compartment and a lowered position which is configured for capturing the golf ball within rear ball capture space located between the rear wall and the internal movable part.

Abstract: The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of components of signal transduction pathways derived from use of the invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments.

Abstract: The present invention provides methods for selecting a suitable anticancer drug therapy, and for identifying and predicting response, for the treatment of colorectal cancer. The present invention also provides methods for monitoring the status of colorectal cancer and monitoring how a patient with colorectal cancer is responding to anticancer drug therapy. The present invention further provides methods for the rational selection of therapy with one or more anticancer drugs tailored to target signal transduction pathway components with dysregulated expression and/or activation levels in patients with somatic mutations in an oncogene.

Abstract: Provided herein is a method for determining whether a human subject with breast cancer will respond to a therapy comprising a tyrosine kinase inhibitor or a biologic. The method includes determining the expression level and/or activation level of various signal transduction molecules such as truncated HER2 protein, full-length HER2 protein, HER3 protein, PI3K protein, and others. The determination of likely response to a tyrosine kinase inhibitor therapy or a biologic therapy involves comparing the expression level and/or activation level of the signal transduction molecule(s) to a reference expression/activation level for the specific signal transduction molecule(s).

Abstract: Systems and methods are provided for identifying meta-events. A plurality of event items are received over a given period of time. The plurality of event items are analyzed to determine one or more areas of interests. One or more characteristics of the plurality of events items is measured. The measured number of event items within the particular area of interest within the given time period are compared against a measured number of even items within the particular area of interest within a previous time period. It is determined that a meta-event has occurred when the difference between the measured number of event items within the particular area of interest compared to the measured number of items within the particular area of interest within a previous time period exceeds a threshold measure of event items.

Abstract: An edgelit recessed luminaire includes a housing that defines an inner cavity and has a pair of side panels. Each side panel includes one or more torsion spring receivers. Further, the edgelit recessed luminaire includes a light engine that includes torsion springs that are pivotally coupled to the light engine via torsion spring brackets. The light engine is removably coupled to the housing such that in an open position, the light engine is suspended from the housing via the torsion springs providing access to the inner cavity and in a closed position, the light engine covers the inner cavity of the housing. Alternatively, a linear light module is removably coupled to the housing.

Abstract: The present invention provides methods for selecting a suitable anticancer drug therapy, and for identifying and predicting response, for the treatment of colorectal cancer. The present invention also provides methods for monitoring the status of colorectal cancer and monitoring how a patient with colorectal cancer is responding to anticancer drug therapy. The present invention further provides methods for the rational selection of therapy with one or more anticancer drugs tailored to target signal transduction pathway components with dysregulated expression and/or activation levels in patients with somatic mutations in an oncogene.

Abstract: The present invention provides assays and methods for predicting the survival of a subject having colorectal cancer (CRC), thereby determining whether the subject will have a good prognosis or poor prognosis. The present invention also provides assays and methods for predicting therapeutic efficacy and/or response to anti-cancer therapeutics in a subject having CRC, thereby selecting a therapeutic regimen to which the subject is likely to be responsive.