Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.

Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.

Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device.

Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.

Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.

Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.

Abstract: A home health care kit in the form of a modularized computer docking station for allowing a user to provide self-monitoring test results that are transferred to a standard desktop or laptop computer for eventual automatic communication over the Internet to the user's physician. In a preferred embodiment, the invention comprises a plurality of interconnected test modules, each configured to provide everything needed to permit a user to conduct a health-related measurement. One such measurement may be that of blood pressure and pulse rate. Another may be actual blood sugar. Still another may be hemoglobin A1C or hemoglobin and another may be cholesterol and triglyceride levels. Each module has an electronics portion and a storage portion. Each such module also has a male connector on one side and a female connector on an opposing side so that the various modules may be interconnected, one to the next in sequence.

Abstract: A sphygmomanometer cuff assembly, air pump, pressure sensor and release valve are contained in an otherwise conventional apparatus. Alternative embodiments are illustrated and discussed herein. In one such embodiment the sphygmomanometer cuff is nominally positioned within the apparatus structure and is extended outside the apparatus housing during the measurement. In another embodiment, the cuff is always external of the apparatus structure and is easily connected to the apparatus at special ports during the measurement. In yet another embodiment, the cuff is always internal of the apparatus structure and is readily accessible through an aperture in the housing surface of the apparatus to permit the measurement to take place. Preferably, in each of these alternative embodiments a hinged or slidable door or panel protects the cuff or cuff ports between measurements.

Abstract: A sphygmomanometer cuff assembly, air pump, pressure sensor and release valve are contained in an otherwise conventional computer mouse controller. Various alternative embodiments are illustrated and discussed herein. In one such embodiment the sphygmomanometer cuff is nominally positioned within the mouse structure and is extended outside the mouse housing during the measurement. In another embodiment, the cuff is always external of the mouse structure and is easily connected to the mouse at special ports during the measurement. In yet another embodiment, the cuff is always internal of the mouse structure and is readily accessible through an aperture in the housing surface of the mouse to permit the measurement to take place. Preferably, in each of these alternative embodiments a hinged or slidable door or panel protects the cuff or cuff ports between measurements.

Abstract: A sphygmomanometer cuff assembly, air pump, pressure sensor and release valve are contained in an otherwise conventional computer mouse controller or are attached to a cell phone, television remote control or directly to a computer. In one embodiment the sphygmomanometer cuff is nominally positioned within a mouse structure and is extended outside the mouse housing during the measurement. In another embodiment, the cuff is always external of the mouse structure and is easily connected to the mouse at special ports during the measurement. In yet another embodiment, the cuff is always internal of the mouse structure and is readily accessible through an aperture in the housing surface of the mouse to permit the measurement to take place. In yet another embodiment, a wrist cuff and associated pump, sensor and valve are designed to be selectively connected to a cell phone to which appropriate software has been downloaded from a computer.

Abstract: A sphygmomanometer cuff assembly, air pump, pressure sensor and release valve are contained in an otherwise conventional computer mouse controller or are attached to a cell phone. In one embodiment the sphygmomanometer cuff is nominally positioned within a mouse structure and is extended outside the mouse housing during the measurement. In another embodiment, the cuff is always external of the mouse structure and is easily connected to the mouse at special ports during the measurement. In yet another embodiment, the cuff is always internal of the mouse structure and is readily accessible through an aperture in the housing surface of the mouse to permit the measurement to take place. In yet another embodiment, a wrist cuff and associated pump, sensor and valve are designed to be selectively connected to a cell phone to which appropriate software has been downloaded from a computer. In yet another embodiment, the cuff and associated components are connected directly to a computer.

Abstract: A sphygmomanometer cuff assembly, air pump, pressure sensor and release valve are contained in an otherwise conventional computer mouse controller. Three alternative embodiments are illustrated and discussed herein. In one such embodiment the sphygmomanometer cuff is nominally positioned within the mouse structure and is extended outside the mouse housing during the measurement. In another embodiment, the cuff is always external of the mouse structure and is easily connected to the mouse at special ports during the measurement. In yet another embodiment, the cuff is always internal of the mouse structure and is readily accessible through an aperture in the housing surface of the mouse to permit the measurement to take place. Preferably, in each of these alternative embodiments a hinged or slidable door or panel protects the cuff or cuff ports between measurements.

Abstract: An eyebrow guide configured as an adjustable facial frame designed to be centered over the nose and having a pair of selectively shaped and positioned eyebrow templates for use in guiding the appliance used to shape, color, shave, cut or otherwise cosmetically treat the user's eyebrows. The frame comprises a nosepiece designed to overly the nose to both center and stabilize the guide. The frame also has a pair of opposed side members which extend from the nosepiece toward and over the ears in a manner similar to conventional eyeglass frames to further stabilize and support the guide. Intermediate of the eyebrow templates and the nose piece is a three-piece, double hinged member designed to provide adjustment for virtually any facial dimensions in regard to distance between the eyebrows and the nose as well as their relative depth. In addition, the upper portion of this double-hinged member provides a dial for eyebrow angle adjustment for the templates.

Abstract: Methods and systems are provided for conducting a reaction at a selected temperature or range of temperatures over time. An array device is provided. The array device contains separate reaction chambers and is formed as an elastomeric block from multiple layers. At least one layer has at least one recess that recess has at least one deflectable membrane integral to the layer with the recess. The array device has a thermal transfer device proximal to at least one of the reaction chambers. The thermal transfer device is formed to contact a thermal control source. Reagents for carrying out a desired reaction are introduced into the array device. The array device is contacted with a thermal control device such that the thermal control device is in thermal communication with the thermal control source so that a temperature of the reaction in at least one of the reaction chamber is changed as a result of a change in temperature of the thermal control source.

Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device.

Abstract: A manicuring appliance comprising a hand held center section with proximal and distal end sections each of which may be detachable from the center section. Each end section may have a lip shaped to bear against the base of the cuticle. The distal end section comprises a pusher for shaping the cuticle and prepare it for cutting by the proximal end section. The proximal end section includes a cutting blade positioned to properly cut or trim the cuticle along an arc which follows the arc of the cuticle base as the user moves the appliance along the cuticle. Various alternative embodiments of the proximal cutting section and distal pusher section are disclosed.

Abstract: A manicuring appliance comprising a hand held center section with proximal and distal end sections each of which may be detachable from the center section. Each end section may have a lip shaped to bear against the base of the cuticle. The distal end section comprises a pusher for shaping the cuticle and prepare it for cutting by the proximal end section. The proximal end section includes a cutting blade positioned to properly cut or trim the cuticle along an arc which follows the arc of the cuticle base as the user moves the appliance along the cuticle. Various alternative embodiments of the proximal cutting section and distal pusher section are disclosed. In one such cutting embodiment, a safety barrier is positioned near the blade edge to limit the cutting depth.

Abstract: A manicuring appliance comprising a hand held center section with proximal and distal end sections each of which may be detachable from the center section. Each end section may have a lip shaped to bear against the base of the cuticle. The distal end section comprises a pusher for shaping the cuticle and prepare it for cutting by the proximal end section. The proximal end section includes a cutting blade positioned to properly cut or trim the cuticle along an arc which follows the arc of the cuticle base as the user moves the appliance along the cuticle. Various alternative embodiments of the proximal cutting section are disclosed.

Abstract: Electrical equipment such as a personal computer includes a plurality of internal components which require different voltages including low voltages of about five volts for operation. The different voltages are supplied by an internal power supply, with a voltage regulator, which is itself connected to an appropriately transformed high voltage supply typically from an in-the-wall source. Peripherals such as a FAX/modem, CD ROM, or tape recorder are powered by cables plugged into mating sockets in the face of the computer housing. The sockets, in turn, are connected to the appropriate outputs of the internal power supply to obtain appropriate voltage power directly from the host computer in the absence of a transformed connection to a house supply. A switch may be provided at each of the sockets to vary the voltage there. The power supply may be mounted on the computer housing or it may be located away from the housing.

Abstract: Power supplies which include sockets for supplying DC voltages as well as cables for supplying DC voltages to internal components of, for example, a computer are configured to prevent a user from connecting to an inappropriate DC voltage. The apparatus includes a special multiple din socket which provides a different voltage at each din of a subset of the dins, only one din of which is alive at a time. The apparatus includes a switch at each socket operative to select only a single din of a subset of dins at that socket. The illustrative apparatus includes several sockets, each one of which includes a different subset of dins selected by a switch, a single din at a time.