Patents by Inventor Phillip Lazzara

Phillip Lazzara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,4-substituted isoquinoline inhibitors of KEAP1/NRF2 protein-protein interaction
    Patent number: 11396496
    Abstract: Disclosed herein are compounds that can act as inhibitors of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 (“KEAP1/NRF2”) protein-protein interaction, and methods of using the compounds to treat and prevent diseases and disorders, such as COPD, multiple sclerosis, and diabetes, and in the promotion of wound healing. The compounds described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: formula (I), wherein the substituents are as described.
    Type: Grant
    Filed: April 2, 2019
    Date of Patent: July 26, 2022
    Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
    Inventors: Terry Moore, Phillip Lazzara, Brian David, Benjamin Richardson, Atul D. Jain
  • 1,4-SUBSTITUTED ISOQUINOLINE INHIBITORS OF KEAP1/NRF2 PROTEIN-PROTEIN INTERACTION
    Publication number: 20210017135
    Abstract: Disclosed herein are compounds that can act as inhibitors of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 (“KEAP1/NRF2”) protein-protein interaction, and methods of using the compounds to treat and prevent diseases and disorders, such as COPD, multiple sclerosis, and diabetes, and in the promotion of wound healing. The compounds described herein can include compounds of Formula (I) and pharmaceutically acceptable salts thereof: formula (I), wherein the substituents are as described.
    Type: Application
    Filed: April 2, 2019
    Publication date: January 21, 2021
    Inventors: Terry Moore, Phillip Lazzara, Brian David, Benjamin Richardson, Atul D. Jain