Abstract: This disclosure describes a system, method, and non-transitory computer readable media for an ultrasound probe configured to capture ultrasound images of an examination region. The system includes a first set of one or more sensors coupled to the ultrasound probe and configured to estimate a first positional information associated with the ultrasound probe. The system includes a second set of one or more sensors coupled to the ultrasound probe and configured to capture electromagnetic force (EMF) measurements in the examination region to estimate a second positional information associated with the ultrasound probe. The second positional information is used to calibrate the first set of one or more sensors. The system includes a controller configured to use at least one of (i) the first positional information, or (ii) the second positional information to generate a reconstruction of the examination region based on ultrasound images captured by the ultrasound probe.

Abstract: The present invention relates to compounds that are antagonists of the orexin-1 receptor. The compounds have the structural formula (I) defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

Abstract: The present invention relates to compounds that are IL-17A modulators. The compounds have the structural Formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with modulation of IL-17A activity.

Abstract: The present invention relates to compounds that are IL-17A modulators. The compounds have the structural Formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with modulation of IL-17A activity.

Abstract: The present invention relates to compounds that are Nrf2 activators. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with Nrf2 activation.

Abstract: A wayside to railway vehicle communication method including providing a first wayside device with a transmitter device capable of transmitting a data packet message to a railway vehicle travelling along a section of a railway track, through an electric waveform put into a rail of the section, and sending at least one message from the transmitter device to the railway vehicle, wherein the at least one message corresponds to the conversion of the data packet into a modulated electric waveform, the data packet including several data bits providing information relative to a plurality of speed limits the railway vehicle has to respect while travelling along respective portions of the section.

Abstract: A method or system for determining the susceptibility of a dog to periodontal disease and to the development of treatment regimens based upon the levels of susceptibility determined. The method can include determining a characteristic of the dog selected from at least one of a breed of the dog, a shape of the dog's head, a size category of the dog, a weight or body condition of the dog, a predicted size category or weight of the dog as an adult, or an age of the dog. The method can also include comparing the characteristic with a dataset comprising an occurrence of the periodontal disease in other dogs having the at least one characteristic. In addition, the method can include detecting an overall susceptibility level of the dog for the periodontal disease, and/or displaying a customized recommendation on a graphical user interface of the computer based on the overall susceptibility level of the dog.

Abstract: A wayside to railway vehicle communication method including providing a first wayside device with a transmitter device capable of transmitting a data packet message to a railway vehicle traveling along a section of a railway track, through an electric waveform put into a rail of the section, and sending at least one message from the transmitter device to the railway vehicle, wherein the at least one message corresponds to the conversion of the data packet into a modulated electric waveform, the data packet including several data bits providing information relative to a plurality of speed limits the railway vehicle has to respect while traveling along respective portions of the section.

Abstract: A train detection system for a railway track defines a first lateral side and a second lateral side opposite the first lateral side. Two cameras are arranged along the railway track spaced apart from each other. Each camera is placed on either the first lateral side or the second lateral side. The system includes at least one passive target. Each of the passive targets is placed within the field of view of at least one of the cameras and on the opposite lateral side of the railway track with respect to the at least one of the cameras in whose field of view the respective passive target is placed. The system also includes at least one controller adapted to recognise the passive target in the images provided by at least one of the cameras to the controller to determine whether a train is located on the railway track.

Abstract: The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

Abstract: This automatic vehicle control apparatus comprises a first image sensor positioned on a vehicle, able to capture a first global image of a first scene, including an area in front of the vehicle, in a first field of view of said first image sensor; a track occupancy detector for receiving the first global image and deducing therefrom a track occupancy of the vehicle among at least two set of parallel tracks positioned in front of the vehicle; a distinguishable object disposed in the first field of view; and a proper functioning checking apparatus configured for searching, in the first global image, a first specific image of the distinguishable object, and for generating an alert signal in case the first specific image is not found in the first global image.

Abstract: The present invention relates to compounds that are inhibitors of the orexin-1 receptor. The compounds have the structural formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with orexin-1 receptor activity.

Abstract: A train detection system for a railway track defines a first lateral side and a second lateral side opposite the first lateral side. Two cameras are arranged along the railway track spaced apart from each other. Each camera is placed on either the first lateral side or the second lateral side. The system includes at least one passive target. Each of the passive targets is placed within the field of view of at least one of the cameras and on the opposite lateral side of the railway track with respect to the at least one of the cameras in whose field of view the respective passive target is placed. The system also includes at least one controller adapted to recognise the passive target in the images provided by at least one of the cameras to the controller to determine whether a train is located on the railway track.

Abstract: A method for controlling a message from a sender. A referee can evaluate a credential associated with a message to determine it's desirability to the intended recipient, and take an action based upon the results of the determination. A sender that includes a trusted component can send a credential with the message, and the message can be controlled without a referee.

Abstract: This automatic vehicle control apparatus comprises a first image sensor positioned on a vehicle, able to capture a first global image of a first scene, including an area in front of the vehicle, in a first field of view of said first image sensor; a track occupancy detector for receiving the first global image and deducing therefrom a track occupancy of the vehicle among at least two set of parallel tracks positioned in front of the vehicle; a distinguishable object disposed in the first field of view; and a proper functioning checking apparatus configured for searching, in the first global image, a first specific image of the distinguishable object, and for generating an alert signal in case the first specific image is not found in the first global image.

Abstract: A grout tillable prop assembly for supporting a ceiling such as the ceiling of an underground mine. The prop assembly comprising an inner member and an outer member adapted for movement between an extended use configuration and a retracted configuration, a unidirectional grout inlet in an upper part of a sidewall of the outer member to allow grout to pass into the prop, the inner member and the outer member having wall portions and being self-supporting, an air conduit through the prop having an opening adjacent an upper limit of the prop, a pressure relief valve coupled to the air conduit whereby the prop is be brought from the retracted configuration to the extended configuration by application of pressurized air through the air conduit and whereby the extended prop is filled with grout via the unidirectional grout inlet.

Abstract: Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for reducing tumor size in a mammalian subject and for inducing apoptosis in a tumor cell. The methods are effective on tumor cells that are resistant to drugs such as temozolomide, doxorubicin, and geldanamycin, as well as non-resistant tumor cells. Further provided are barbiturate and thiobarbiturates diene compounds for use in treating cancer, and uses, methods and compositions relating to these compounds.

Abstract: Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for reducing tumor size in a mammalian subject and for inducing apoptosis in a tumor cell. The methods are effective on tumor cells that are resistant to drugs such as temozolomide, doxorubicin, and geldanamycin, as well as non-resistant tumor cells. Further provided are barbiturate and thiobarbiturates diene compounds for use in treating cancer, and uses, methods and compositions relating to these compounds.

Abstract: The present invention provides a new and distinct variety of almond tree, named ‘PY2’, substantially as described and illustrated herein, which produces an improved yield, is a compatible pollinator with other varieties, and is ready for harvest at approximately the same time as other varieties. The ‘PY2’ variety is a good replacement for inter-planting with other varieties by providing compatible pollination, similar bloom and harvest times, and improved nut yield.

Abstract: The present invention provides a new and distinct variety of almond tree, named ‘PY1’, substantially as described and illustrated herein, that is a pollinator for existing varieties, and which produces nuts with rare doubles that are similar to existing varieties, with a crop having a fresh earthy taste, that is well suited for roasting, seasoning, oil and flavoring.